Is 12.5 mcg of Vitamin D safe?

Yes — this is 0.8× the recommended daily intake of 0.015 mg, which is within safe limits.

Is 33.5 mg of Vitamin E safe?

Yes — this is 2.2× the recommended daily intake of 15 mg, which is within safe limits.

Is 42.5 mcg of Vitamin K safe?

Yes — this is 0.4× the recommended daily intake of 0.12 mg, which is within safe limits.

Longevity Nutrients by Pure Encapsulations — Ingredients, Evidence & Safety

🟢 89/100

This product is generally safe

Folate: 333mg is 333.0× the Tolerable Upper Intake Level (1.0mg)
Contains proprietary blend — exact ingredient amounts not disclosed
64% of ingredients have research evidence

C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

This formula contains a blend of essential fat-soluble and water-soluble vitamins that support immune function and cellular health. There is strong clinical evidence regarding the roles of vitamins A, C, D, E, and K in maintaining systemic homeostasis. The overall evidence coverage for this specific combination is limited.

AI-generated summary based on research evidence. Not medical advice.

Product Label

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Safety Alerts

⚠️ Folate: 333mg is 333.0× the Tolerable Upper Intake Level (1.0mg)

ℹ️ Contains proprietary blend — exact ingredient amounts not disclosed

Label Data

2 Capsule(s) Serving Size

120 Servings

Other Combinations Product Type

64% Evidence Coverage

Supplement Facts — Evidence Check

Vitamin A

1125 mcg (125% DV)

Vitamin C

125 mg (139% DV)

Vitamin D

12.5 mcg (63% DV)

✅ Within RDA (0.8× RDA of 0.015 mg) 📚 608 studies (Tier A: 16, B: 251)

RDA 0.015mg This product: 0.0125mg UL 0.1mg

Vitamin E

33.5 mg (223% DV)

✅ 2.2× RDA — within safe limits 📚 179 studies (Tier A: 3, B: 90)

RDA 15mg This product: 33.5mg UL 1000mg

Vitamin K

42.5 mcg (35% DV)

✅ Within RDA (0.4× RDA of 0.12 mg) 📚 275 studies (Tier A: 9, B: 175)

RDA 0.12mg This product: 0.0425mg

Thiamine

5 mg (417% DV)

📊 4.2× RDA — above typical dose 📚 76 studies (Tier A: 0, B: 33)

RDA 1.2mg This product: 5mg

Riboflavin

6 mg (462% DV)

📊 4.6× RDA — above typical dose 📚 13 studies (Tier A: 0, B: 1)

RDA 1.3mg This product: 6mg

Niacin

22.5 mg (141% DV)

✅ 1.6× RDA — within safe limits 📚 196 studies (Tier A: 5, B: 63)

RDA 14mg This product: 22.5mg UL 35mg

Vitamin B6

5.85 mg (344% DV)

📊 4.5× RDA — above typical dose (UL: 100 mg) 📚 114 studies (Tier A: 3, B: 35)

RDA 1.3mg This product: 5.85mg UL 100mg

Folate

333 mcg DFE (83% DV)

⚠️ Exceeds Tolerable Upper Intake Level by 333.0× (UL: 1.0 mg) 📚 226 studies (Tier A: 10, B: 105)

RDA 0.4mg This product: 333mg UL 1.0mg

Vitamin B12

250 mcg (10417% DV)

📊 104.2× RDA — above typical dose 📚 139 studies (Tier A: 1, B: 44)

RDA 0.0024mg This product: 0.25mg

Biotin

1000 mcg (3333% DV)

📊 33.3× RDA — above typical dose 📚 27 studies (Tier A: 0, B: 11)

RDA 0.03mg This product: 1.0mg

Pantothenic Acid

25 mg (500% DV)

📊 5.0× RDA — above typical dose 📚 2 studies — no high-quality reviews

RDA 5mg This product: 25mg

Choline

20 mg (4% DV)

📊 Market median: 125.0mg (294 products) 📚 38 studies (Tier A: 1, B: 7)

RDA 550mg This product: 20mg UL 3500mg

Iodine

100 mcg (67% DV)

✅ Within RDA (0.7× RDA of 0.15 mg) 📚 245 studies (Tier A: 4, B: 133)

RDA 0.15mg This product: 0.1mg UL 1.1mg

Zinc

7.5 mg (68% DV)

✅ Within RDA (0.7× RDA of 11 mg) 📚 263 studies (Tier A: 6, B: 134)

RDA 11mg This product: 7.5mg UL 40mg

Selenium

100 mcg (182% DV)

✅ 1.8× RDA — within safe limits 📚 173 studies (Tier A: 0, B: 67)

RDA 0.055mg This product: 0.1mg UL 0.4mg

Manganese

1 mg (43% DV)

✅ Within RDA (0.4× RDA of 2.3 mg) 📚 9 studies — no high-quality reviews

RDA 2.3mg This product: 1mg UL 11mg

Chromium

200 mcg (571% DV)

📊 5.7× RDA — above typical dose 📚 199 studies (Tier A: 1, B: 55)

RDA 0.035mg This product: 0.2mg

Vitamin K2

7.5 mcg

✅ Within RDA (0.1× RDA of 0.12 mg) 📚 275 studies (Tier A: 9, B: 175)

RDA 0.12mg This product: 0.0075mg

Boron Glycinate

1 mg

📊 Market median: 3.0mg (58 products) 📚 3 studies — no high-quality reviews

This product: 1mg UL 20mg

Vanadium

50 mcg

📊 Market median: 0.5mg (6 products) 📚 1 studies (Tier A: 0, B: 1)

This product: 0.05mg UL 1.8mg

Proprietary Mixed Carotenoid Blend

212 mcg

Inositol

62.5 mg

📊 Market median: 550.0mg (217 products) 📚 29 studies (Tier A: 0, B: 5)

This product: 62.5mg

Alpha Lipoic Acid

37.5 mg

📊 Market median: 200.0mg (198 products) 📚 6 studies — no high-quality reviews

This product: 37.5mg

MacularSynergy Extra

CognitivePro Complex

Cardio Polyphenol Complex

Other Ingredients

Vegetarian Capsule Calcium Phosphate Ascorbyl Palmitate Silicon Dioxide

Label Claims — Verification

❓ Nutrient

❓ All Other

❓ Structure/Function

All Other (99% of products) Structure/Function (76% of products) Nutrient (58% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

Recommendations: As a dietary supplement, take 2 capsules, 2 times daily, with meals.

⚠️ Warnings & Precautions

Warning: Vitamin K may be contraindicated with Coumadin (Warfarin). If you are pregnant or lactating, have any health condition or are taking any medication, particularly blood thinning medication, consult your health professional before use.

Keep out of the reach of children.

Use only if safety seal is intact.

🧪 Formulation Notes

Certified Gluten-free by the Gluten-Free Certification Organization, www.gluten.org

With Metafolin L-5-MTHF; Multivitamin/mineral complex for healthy aging

Gluten-free, non-GMO & hypoallergenic

Additional Information

Store in a cool, dry place.

Scan to learn about our hypoallergenic supplements

Contents may not fill package in order to accommodate required labeling. Please rely on stated quantity.

GF (Gluten Free)

Product Details

UPC / SKU 7 66298 01181 3

DSLD Entry Date 2021-03-25

Product Type Other Combinations

Form Capsule

Brand Pure Encapsulations

DSLD ID 246190

Data Updated 2026-04-11

Research Evidence

337 Research Sources

54 Avg Quality Score

161 Meta Analysis

68 Systematic Review

51 Rct

48 Clinical Trial

2 Other

2 Regulatory Source

1 Narrative Review

1 Cochrane Review

1 Guideline

1 Openfda Safety

A Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age

Meta Analysis The Cochrane database of systematic reviews 2017

PubMed DOI Cochrane

A Vitamin A supplementation for the prevention of morbidity and mortality in infants six months of age or less

Meta Analysis The Cochrane database of systematic reviews 2011

PubMed DOI Cochrane

A Vitamin A supplementation for reducing the risk of mother-to-child transmission of HIV infection

Meta Analysis The Cochrane database of systematic reviews 2011

PubMed DOI Cochrane

A Vitamin A supplements for preventing mortality, illness, and blindness in children aged under 5: systematic review and meta-analysis

Meta Analysis BMJ (Clinical research ed.) 2011

PubMed DOI

A Fortification of staple foods with vitamin A for vitamin A deficiency

Systematic Review The Cochrane database of systematic reviews 2019

PubMed DOI Cochrane

A Vitamin A supplementation for the prevention of morbidity and mortality in infants one to six months of age

Narrative Review The Cochrane database of systematic reviews 2016

PubMed DOI Cochrane

A Vitamin A and fish oils for preventing the progression of retinitis pigmentosa

Meta Analysis The Cochrane database of systematic reviews 2020

PubMed DOI

A Exercise training-induced changes in exerkine concentrations may be relevant to the metabolic control of type 2 diabetes mellitus patients: A systematic review and meta-analysis of randomized controlled trials

Meta Analysis Journal of sport and health science 2023

PubMed DOI

A Food fortification with multiple micronutrients: impact on health outcomes in general population

Meta Analysis The Cochrane database of systematic reviews 2019

PubMed DOI

A Oral vitamin A supplements to prevent acute upper respiratory tract infections in children up to seven years of age

Meta Analysis The Cochrane database of systematic reviews 2024

PubMed DOI

View all evidence for Vitamin A →