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Hair, Skin & Nails

product on market Tablet or Pill 21st Century Safety: 89/100
89/100

This product is generally safe

  • Folate: 42mg is 42.0× the Tolerable Upper Intake Level (1.0mg)
  • Contains proprietary blend — exact ingredient amounts not disclosed
  • 60% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

The profile includes vitamins A, C, D3, and E, which are moderately supported by research for maintaining skin integrity and cellular health. Thiamine contributes to energy metabolism, though the overall evidence coverage for this specific combination is limited. The formulation maintains a high safety score.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folate: 42mg is 42.0× the Tolerable Upper Intake Level (1.0mg)

Contains proprietary blend — exact ingredient amounts not disclosed

Label

Product Label

Label for Hair, Skin & Nails
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
Other Combinations
Product Type
60%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Vitamin A
750 mcg RAE (80% DV)
Vitamin C
50 mg (60% DV)
1.2 mcg (6% DV)
Within RDA (0.1× RDA) 608 studies (A:16, B:251)
25 mg (170% DV)
1.7× RDA — within safe limits 179 studies (A:3, B:90)
5 mg (420% DV)
4.2× RDA — above typical dose 76 studies (A:0, B:33)
5 mg (380% DV)
3.8× RDA — above typical dose 13 studies (A:0, B:1)
7.5 mg (45% DV)
Within RDA (0.5× RDA) 196 studies (A:5, B:63)
6.5 mg (380% DV)
5.0× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
42 mcg DFE (10% DV)
Exceeds UL by 42.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
25 mcg (1040% DV)
10.4× RDA — above typical dose 139 studies (A:1, B:44)
25 mcg (80% DV)
Within RDA (0.8× RDA) 27 studies (A:0, B:11)
15 mg (300% DV)
3.0× RDA — within safe limits 2 studies — no high-quality reviews
25 mg (4% DV)
Market median: 125.0mg (294 products) 38 studies (A:1, B:7)
Calcium
125 mg (10% DV)
Iron
3.3 mg (20% DV)
58 mg (4% DV)
Within RDA (0.1× RDA) 13 studies (A:0, B:3)
150 mcg (100% DV)
Within RDA (1.0× RDA) 245 studies (A:4, B:133)
20 mg (20% DV)
Market median: 500.0mg (1 products) 316 studies (A:8, B:159)
0.6 mg (4% DV)
Within RDA (0.1× RDA) 263 studies (A:6, B:134)
0.6 mg (25% DV)
Within RDA (0.3× RDA) 9 studies — no high-quality reviews
Potassium
5 mg (1% DV)
10 mg
Market median: 496.0mg (192 products) 20 studies — no high-quality reviews
10 mg
Market median: 550.0mg (217 products) 29 studies (A:0, B:5)
10 mg
Market median: 500.0mg (9 products) 7 studies — no high-quality reviews
DNA
10 mg
RNA
10 mg
7.2 mg
Market median: 500.0mg (223 products) 24 studies (A:0, B:1)
Market median: 4002.0mg (1 products) 21 studies (A:0, B:2)
50 mg
Market median: 60.0mg (94 products) 13 studies (A:0, B:7)
Proprietary Herbal Support Blend
310 mg

Other Ingredients

Cellulose Stearic Acid Silicon Dioxide Maltodextrin Croscarmellose Sodium Contains Less Than 2% of
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: As a dietary supplement, adults take one (1) tablet with any meal, twice daily or as directed by a healthcare provider. Do not exceed recommended dosage.

Warnings & Precautions

Do not exceed recommended dosage.

Warning: Consult a healthcare provider prior to use if pregnant, nursing, on medications, have a medical condition or are planning a medical procedure.

Stop use and contact a physician if adverse reactions occur.

Not intended for use by persons under the age of 18. Keep out of reach of children.

Do not use if product appears to be tampered with or seal is broken.

Warning: Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6. Keep this product out of reach of children. In case of accidental overdose, call a doctor or poison control center immediately.

Contains soy and fish (DNA).

Formulation Notes

No added Artificial Flavors.

Gluten free

Warning: Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6.

Contains soy and fish (DNA).

Additional Information

Individual results may vary.

Store at room temperature.

Healthy renewal formula Advanced formula Herbs, Vitamins and Mineral Hair, Skin & Nail Support

Gluten free

Guaranteed quality Laboratory tested

Metadata

Product Details

UPC / SKU7 40985 21434 3
DSLD Entry Date2019-08-23
Product TypeOther Combinations
FormTablet or Pill
Brand21st Century
DSLD ID205740
Data Updated2026-04-11
Research

Research Evidence

337
Research Sources
54
Avg Quality
161
Meta Analysis
68
Systematic Review
51
Rct
48
Clinical Trial
2
Other
2
Regulatory Source
1
Narrative Review
1
Cochrane Review
1
Guideline
1
Openfda Safety
A Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Vitamin A supplementation for the prevention of morbidity and mortality in infants six months of age or less
Meta Analysis The Cochrane database of systematic reviews 2011 PubMed DOI
A Vitamin A supplementation for reducing the risk of mother-to-child transmission of HIV infection
Meta Analysis The Cochrane database of systematic reviews 2011 PubMed DOI
A Vitamin A supplements for preventing mortality, illness, and blindness in children aged under 5: systematic review and meta-analysis
Meta Analysis BMJ (Clinical research ed.) 2011 PubMed DOI
A Fortification of staple foods with vitamin A for vitamin A deficiency
Systematic Review The Cochrane database of systematic reviews 2019 PubMed DOI
A Vitamin A supplementation for the prevention of morbidity and mortality in infants one to six months of age
Narrative Review The Cochrane database of systematic reviews 2016 PubMed DOI
A Vitamin A and fish oils for preventing the progression of retinitis pigmentosa
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
A Exercise training-induced changes in exerkine concentrations may be relevant to the metabolic control of type 2 diabetes mellitus patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Journal of sport and health science 2023 PubMed DOI
A Food fortification with multiple micronutrients: impact on health outcomes in general population
Meta Analysis The Cochrane database of systematic reviews 2019 PubMed DOI
A Oral vitamin A supplements to prevent acute upper respiratory tract infections in children up to seven years of age
Meta Analysis The Cochrane database of systematic reviews 2024 PubMed DOI
View all evidence for Vitamin A →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.