Hair, Skin & Nails

product on market Tablet or Pill 21st Century 🟢 Safety: 89/100
Brand: 21st Century
🟢 89/100

This product is generally safe

  • Folate: 42mg is 42.0× the Tolerable Upper Intake Level (1.0mg)
  • Contains proprietary blend — exact ingredient amounts not disclosed
  • 60% of ingredients have research evidence
C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Folate: 42mg is 42.0× the Tolerable Upper Intake Level (1.0mg)
ℹ️ Contains proprietary blend — exact ingredient amounts not disclosed

Label Data

1 Tablet(s) Serving Size
Other Combinations Product Type
60% Evidence Coverage

Supplement Facts — Evidence Check

Vitamin A
750 mcg RAE (80% DV)
Vitamin C
50 mg (60% DV)
1.2 mcg (6% DV)
✅ Within RDA (0.1× RDA of 0.015 mg) 📚 604 studies (Tier A: 16, B: 251)
RDA 0.015mg This product: 0.0012mg UL 0.1mg
25 mg (170% DV)
✅ 1.7× RDA — within safe limits 📚 177 studies (Tier A: 3, B: 90)
RDA 15mg This product: 25mg UL 1000mg
5 mg (420% DV)
📊 4.2× RDA — above typical dose 📚 76 studies (Tier A: 0, B: 33)
RDA 1.2mg This product: 5mg
5 mg (380% DV)
📊 3.8× RDA — above typical dose 📚 12 studies (Tier A: 0, B: 1)
RDA 1.3mg This product: 5mg
7.5 mg (45% DV)
✅ Within RDA (0.5× RDA of 14 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 7.5mg UL 35mg
6.5 mg (380% DV)
📊 5.0× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 6.5mg UL 100mg
42 mcg DFE (10% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 42.0× (UL: 1.0 mg) 📚 225 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 42mg UL 1.0mg
25 mcg (1040% DV)
📊 10.4× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 0.025mg
25 mcg (80% DV)
✅ Within RDA (0.8× RDA of 0.03 mg) 📚 26 studies (Tier A: 0, B: 11)
RDA 0.03mg This product: 0.025mg
15 mg (300% DV)
✅ 3.0× RDA — within safe limits 📚 1 studies — no high-quality reviews
RDA 5mg This product: 15mg
25 mg (4% DV)
📊 Market median: 125.0mg (294 products) 📚 36 studies (Tier A: 1, B: 7)
RDA 550mg This product: 25mg UL 3500mg
Calcium
125 mg (10% DV)
Iron
3.3 mg (20% DV)
58 mg (4% DV)
✅ Within RDA (0.1× RDA of 700 mg) 📚 12 studies (Tier A: 0, B: 3)
RDA 700mg This product: 58mg UL 4000mg
150 mcg (100% DV)
✅ Within RDA (1.0× RDA of 0.15 mg) 📚 243 studies (Tier A: 4, B: 133)
RDA 0.15mg This product: 0.15mg UL 1.1mg
20 mg (20% DV)
📊 Market median: 4002.0mg (1 products) 📚 20 studies (Tier A: 0, B: 2)
This product: 20mg
0.6 mg (4% DV)
✅ Within RDA (0.1× RDA of 11 mg) 📚 258 studies (Tier A: 6, B: 134)
RDA 11mg This product: 0.6mg UL 40mg
0.6 mg (25% DV)
✅ Within RDA (0.3× RDA of 2.3 mg) 📚 8 studies — no high-quality reviews
RDA 2.3mg This product: 0.6mg UL 11mg
Potassium
5 mg (1% DV)
10 mg
📊 Market median: 496.0mg (192 products) 📚 20 studies — no high-quality reviews
This product: 10mg
10 mg
📊 Market median: 550.0mg (217 products) 📚 29 studies (Tier A: 0, B: 5)
This product: 10mg
10 mg
📊 Market median: 500.0mg (9 products)
This product: 10mg
DNA
10 mg
RNA
10 mg
7.2 mg
📊 Market median: 500.0mg (223 products) 📚 22 studies (Tier A: 0, B: 1)
This product: 7.2mg
3.5 mg
📊 Market median: 4002.0mg (1 products) 📚 20 studies (Tier A: 0, B: 2)
This product: 3.5mg
50 mg
📊 Market median: 60.0mg (94 products) 📚 13 studies (Tier A: 0, B: 7)
This product: 50mg
Proprietary Herbal Support Blend
310 mg

Other Ingredients

Cellulose Stearic Acid Silicon Dioxide Maltodextrin Croscarmellose Sodium Contains Less Than 2% of

Label Claims — Verification

❓ Nutrient
❓ All Other
❓ Structure/Function
All Other (99% of products) Structure/Function (76% of products) Nutrient (58% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

Directions: As a dietary supplement, adults take one (1) tablet with any meal, twice daily or as directed by a healthcare provider. Do not exceed recommended dosage.

⚠️ Warnings & Precautions

Do not exceed recommended dosage.

Warning: Consult a healthcare provider prior to use if pregnant, nursing, on medications, have a medical condition or are planning a medical procedure.

Stop use and contact a physician if adverse reactions occur.

Not intended for use by persons under the age of 18. Keep out of reach of children.

Do not use if product appears to be tampered with or seal is broken.

Warning: Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6. Keep this product out of reach of children. In case of accidental overdose, call a doctor or poison control center immediately.

Contains soy and fish (DNA).

🧪 Formulation Notes

No added Artificial Flavors.

Gluten free

Warning: Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6.

Contains soy and fish (DNA).

Additional Information

Individual results may vary.

Store at room temperature.

Healthy renewal formula Advanced formula Herbs, Vitamins and Mineral Hair, Skin & Nail Support

Gluten free

Guaranteed quality Laboratory tested

Product Details

UPC / SKU 7 40985 21434 3
DSLD Entry Date 2019-08-23
Product Type Other Combinations
Form Tablet or Pill
Brand 21st Century
DSLD ID 205740
Data Updated 2026-04-11

Research Evidence

337 Research Sources
54 Avg Quality Score
161 Meta Analysis
68 Systematic Review
51 Rct
48 Clinical Trial
2 Other
2 Regulatory Source
1 Narrative Review
1 Cochrane Review
1 Guideline
1 Openfda Safety
A Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age
Meta Analysis The Cochrane database of systematic reviews 2017
PubMed DOI Cochrane
A Vitamin A supplementation for the prevention of morbidity and mortality in infants six months of age or less
Meta Analysis The Cochrane database of systematic reviews 2011
PubMed DOI Cochrane
A Vitamin A supplementation for reducing the risk of mother-to-child transmission of HIV infection
Meta Analysis The Cochrane database of systematic reviews 2011
PubMed DOI Cochrane
A Vitamin A supplements for preventing mortality, illness, and blindness in children aged under 5: systematic review and meta-analysis
Meta Analysis BMJ (Clinical research ed.) 2011
PubMed DOI
A Fortification of staple foods with vitamin A for vitamin A deficiency
Systematic Review The Cochrane database of systematic reviews 2019
PubMed DOI Cochrane
A Vitamin A supplementation for the prevention of morbidity and mortality in infants one to six months of age
Narrative Review The Cochrane database of systematic reviews 2016
PubMed DOI Cochrane
A Vitamin A and fish oils for preventing the progression of retinitis pigmentosa
Meta Analysis The Cochrane database of systematic reviews 2020
PubMed DOI
A Exercise training-induced changes in exerkine concentrations may be relevant to the metabolic control of type 2 diabetes mellitus patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Journal of sport and health science 2023
PubMed DOI
A Food fortification with multiple micronutrients: impact on health outcomes in general population
Meta Analysis The Cochrane database of systematic reviews 2019
PubMed DOI
A Oral vitamin A supplements to prevent acute upper respiratory tract infections in children up to seven years of age
Meta Analysis The Cochrane database of systematic reviews 2024
PubMed DOI
View all evidence for Vitamin A →

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