Is 50 mcg of Vitamin D safe?

This is 3.3× the recommended daily intake of 0.015 mg. While above typical doses, it may still be within safe limits (UL: 0.1 mg).

Is 20 mg of Vitamin E safe?

Yes — this is 1.3× the recommended daily intake of 15 mg, which is within safe limits.

Is 3 mg of Thiamine safe?

Yes — this is 2.5× the recommended daily intake of 1.2 mg, which is within safe limits.

O.N.E. Multivitamin by Pure Encapsulations — Ingredients, Evidence & Safety

🟢 100/100

This product looks safe

No ingredients exceed tolerable upper intake levels
62% of ingredients have research evidence

A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

This formula contains essential vitamins A, C, D, E, and thiamine, which are supported by strong evidence for maintaining immune function and cellular health. These nutrients play critical roles in antioxidant defense and metabolic processes. The overall evidence coverage for this specific combination is limited.

AI-generated summary based on research evidence. Not medical advice.

Product Label

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Label Data

1 Capsule(s) Serving Size

30 Servings

Other Combinations Product Type

62% Evidence Coverage

Supplement Facts — Evidence Check

Vitamin A

1125 mcg (125% DV)

Vitamin C

180 mg (200% DV)

Vitamin D

50 mcg (250% DV)

📊 3.3× RDA — above typical dose (UL: 0.1 mg) 📚 608 studies (Tier A: 16, B: 251)

RDA 0.015mg This product: 0.05mg UL 0.1mg

Vitamin E

20 mg (134% DV)

✅ 1.3× RDA — within safe limits 📚 179 studies (Tier A: 3, B: 90)

RDA 15mg This product: 20mg UL 1000mg

Thiamine

3 mg (250% DV)

✅ 2.5× RDA — within safe limits 📚 76 studies (Tier A: 0, B: 33)

RDA 1.2mg This product: 3mg

Riboflavin

3 mg (231% DV)

✅ 2.3× RDA — within safe limits 📚 13 studies (Tier A: 0, B: 1)

RDA 1.3mg This product: 3mg

Niacin

20 mg (125% DV)

✅ 1.4× RDA — within safe limits 📚 196 studies (Tier A: 5, B: 63)

RDA 14mg This product: 20mg UL 35mg

Vitamin B6

4 mg (235% DV)

📊 3.1× RDA — above typical dose (UL: 100 mg) 📚 114 studies (Tier A: 3, B: 35)

RDA 1.3mg This product: 4mg UL 100mg

Metafolin

667 mcg DFE (167% DV)

Vitamin B12

500 mcg (20833% DV)

📊 208.3× RDA — above typical dose 📚 139 studies (Tier A: 1, B: 44)

RDA 0.0024mg This product: 0.5mg

Biotin

300 mcg (1000% DV)

📊 10.0× RDA — above typical dose 📚 27 studies (Tier A: 0, B: 11)

RDA 0.03mg This product: 0.3mg

Pantothenic Acid

10 mg (200% DV)

✅ 2.0× RDA — within safe limits 📚 2 studies — no high-quality reviews

RDA 5mg This product: 10mg

Choline

25 mg (5% DV)

📊 Market median: 125.0mg (294 products) 📚 38 studies (Tier A: 1, B: 7)

RDA 550mg This product: 25mg UL 3500mg

Iodine

150 mcg (100% DV)

✅ Within RDA (1.0× RDA of 0.15 mg) 📚 245 studies (Tier A: 4, B: 133)

RDA 0.15mg This product: 0.15mg UL 1.1mg

Zinc

25 mg (227% DV)

✅ 2.3× RDA — within safe limits 📚 263 studies (Tier A: 6, B: 134)

RDA 11mg This product: 25mg UL 40mg

Selenium

70 mcg (127% DV)

✅ 1.3× RDA — within safe limits 📚 173 studies (Tier A: 0, B: 67)

RDA 0.055mg This product: 0.07mg UL 0.4mg

Manganese

2 mg (87% DV)

✅ Within RDA (0.9× RDA of 2.3 mg) 📚 9 studies — no high-quality reviews

RDA 2.3mg This product: 2mg UL 11mg

Chromium

200 mcg (571% DV)

📊 5.7× RDA — above typical dose 📚 199 studies (Tier A: 1, B: 55)

RDA 0.035mg This product: 0.2mg

Molybdenum

75 mcg (167% DV)

✅ 1.7× RDA — within safe limits 📚 3 studies — no high-quality reviews

RDA 0.045mg This product: 0.075mg UL 2mg

Boron

1 mg

📊 Market median: 3.0mg (58 products) 📚 3 studies — no high-quality reviews

This product: 1mg UL 20mg

Inositol

25 mg

📊 Market median: 550.0mg (217 products) 📚 29 studies (Tier A: 0, B: 5)

This product: 25mg

MicroActive CoQ10-cyclodextrin Complex

50 mg

📊 Market median: 100.0mg (283 products) 📚 144 studies (Tier A: 1, B: 64)

This product: 50mg UL 1200mg

Alpha-Lipoic Acid

50 mg

📊 Market median: 200.0mg (198 products) 📚 6 studies — no high-quality reviews

This product: 50mg

FloraGlo

3 mg

Zeaxanthin

500 mcg

📊 Market median: 4.0mg (32 products)

This product: 0.5mg

Lycopene

500 mcg

📊 Market median: 10.0mg (35 products) 📚 6 studies (Tier A: 0, B: 2)

This product: 0.5mg

Other Ingredients

Cellulose Water Plant Fiber Ascorbyl Palmitate Potato Starch

Label Claims — Verification

❓ Nutrient

❓ All Other

❓ Structure/Function

All Other (99% of products) Structure/Function (76% of products) Nutrient (58% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

Recommendations: As a dietary supplement, take 1 capsule daily, with a meal.

⚠️ Warnings & Precautions

Warning: If you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.

Keep out of the reach of children.

Use only if safety seal is intact.

🧪 Formulation Notes

Certified gluten free by the Gluten-Free Certification Organization, www.gluten.org

Once-daily nutrient essentials with sustained release CoQ10; Multivitamin/mineral formula for daily wellness

Gluten-free, non-GMO & hypoallergenic

Product may have a mottled appearance.

Additional Information

Store in a cool, dry place.

Contents may not fill package in order to accommodate required labeling. Please rely on stated quantity. Scan to learn about our hypoallergenic supplements

GFCO.org (Gluten-Free Certification Organization)

Product Details

UPC / SKU 7 66298 02313 7

DSLD Entry Date 2023-07-18

Product Type Other Combinations

Form Capsule

Brand Pure Encapsulations

DSLD ID 294034

Data Updated 2026-04-11

Research Evidence

337 Research Sources

54 Avg Quality Score

161 Meta Analysis

68 Systematic Review

51 Rct

48 Clinical Trial

2 Other

2 Regulatory Source

1 Narrative Review

1 Cochrane Review

1 Guideline

1 Openfda Safety

A Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age

Meta Analysis The Cochrane database of systematic reviews 2017

PubMed DOI Cochrane

A Vitamin A supplementation for the prevention of morbidity and mortality in infants six months of age or less

Meta Analysis The Cochrane database of systematic reviews 2011

PubMed DOI Cochrane

A Vitamin A supplementation for reducing the risk of mother-to-child transmission of HIV infection

Meta Analysis The Cochrane database of systematic reviews 2011

PubMed DOI Cochrane

A Vitamin A supplements for preventing mortality, illness, and blindness in children aged under 5: systematic review and meta-analysis

Meta Analysis BMJ (Clinical research ed.) 2011

PubMed DOI

A Fortification of staple foods with vitamin A for vitamin A deficiency

Systematic Review The Cochrane database of systematic reviews 2019

PubMed DOI Cochrane

A Vitamin A supplementation for the prevention of morbidity and mortality in infants one to six months of age

Narrative Review The Cochrane database of systematic reviews 2016

PubMed DOI Cochrane

A Vitamin A and fish oils for preventing the progression of retinitis pigmentosa

Meta Analysis The Cochrane database of systematic reviews 2020

PubMed DOI

A Exercise training-induced changes in exerkine concentrations may be relevant to the metabolic control of type 2 diabetes mellitus patients: A systematic review and meta-analysis of randomized controlled trials

Meta Analysis Journal of sport and health science 2023

PubMed DOI

A Food fortification with multiple micronutrients: impact on health outcomes in general population

Meta Analysis The Cochrane database of systematic reviews 2019

PubMed DOI

A Oral vitamin A supplements to prevent acute upper respiratory tract infections in children up to seven years of age

Meta Analysis The Cochrane database of systematic reviews 2024

PubMed DOI

View all evidence for Vitamin A →