Estrium Natural Tropical Mango Flavor by Metagenics — Ingredients, Evidence & Safety

🟢 100/100

This product looks safe

No ingredients exceed tolerable upper intake levels
51% of ingredients have research evidence

A Label Compliance Grade

Product Label

Label for Estrium Natural Tropical Mango Flavor

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Label Data

46 Gram(s) Serving Size

14 Servings

Other Combinations Product Type

51% Evidence Coverage

Supplement Facts — Evidence Check

Calories

160 {Calories}

Fat

4 Gram(s)

Cholesterol

Sodium

50 mg

Potassium

300 mg

Total Carbohydrates

22 Gram(s)

Protein

15 Gram(s)

Vitamin A

1250 IU (25% DV)

Vitamin A

2500 IU (50% DV)

Vitamin C

60 mg (100% DV)

Calcium

350 mg (35% DV)

Iron

9 mg (50% DV)

Vitamin D

40 IU (10% DV)

✅ Within RDA (0.1× RDA of 0.015 mg) 📚 604 studies (Tier A: 16, B: 251)

RDA 0.015mg This product: 0.001mg UL 0.1mg

Vitamin E

300 IU (1000% DV)

📊 13.4× RDA — above typical dose (UL: 1000 mg) 📚 177 studies (Tier A: 3, B: 90)

RDA 15mg This product: 201.0mg UL 1000mg

Thiamine

0.75 mg (50% DV)

✅ Within RDA (0.6× RDA of 1.2 mg) 📚 76 studies (Tier A: 0, B: 33)

RDA 1.2mg This product: 0.75mg

Riboflavin

0.85 mg (50% DV)

✅ Within RDA (0.7× RDA of 1.3 mg) 📚 12 studies (Tier A: 0, B: 1)

RDA 1.3mg This product: 0.85mg

Niacin

10 mg (50% DV)

✅ Within RDA (0.7× RDA of 14 mg) 📚 193 studies (Tier A: 5, B: 63)

RDA 14mg This product: 10mg UL 35mg

Vitamin B6

50 mg (2500% DV)

📊 38.5× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)

RDA 1.3mg This product: 50mg UL 100mg

Folic Acid

400 mcg (100% DV)

✅ Within RDA (1.0× RDA of 0.4 mg) 📚 225 studies (Tier A: 10, B: 105)

RDA 0.4mg This product: 0.4mg UL 1.0mg

Vitamin B12

30 mcg (500% DV)

📊 12.5× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)

RDA 0.0024mg This product: 0.03mg

Biotin

150 mcg (50% DV)

📊 5.0× RDA — above typical dose 📚 26 studies (Tier A: 0, B: 11)

RDA 0.03mg This product: 0.15mg

Pantothenic Acid

5 mg (50% DV)

✅ Within RDA (1.0× RDA of 5 mg) 📚 1 studies — no high-quality reviews

RDA 5mg This product: 5mg

Phosphorus

260 mg (25% DV)

✅ Within RDA (0.4× RDA of 700 mg) 📚 12 studies (Tier A: 0, B: 3)

RDA 700mg This product: 260mg UL 4000mg

Iodine

75 mcg (50% DV)

✅ Within RDA (0.5× RDA of 0.15 mg) 📚 243 studies (Tier A: 4, B: 133)

RDA 0.15mg This product: 0.075mg UL 1.1mg

Magnesium

240 mg (60% DV)

📊 Market median: 4002.0mg (1 products) 📚 20 studies (Tier A: 0, B: 2)

This product: 240mg

Zinc

7.5 mg (50% DV)

✅ Within RDA (0.7× RDA of 11 mg) 📚 258 studies (Tier A: 6, B: 134)

RDA 11mg This product: 7.5mg UL 40mg

Copper

1 mg (50% DV)

✅ 1.1× RDA — within safe limits 📚 36 studies (Tier A: 0, B: 11)

RDA 0.9mg This product: 1mg UL 10mg

Manganese

1 mg (50% DV)

✅ Within RDA (0.4× RDA of 2.3 mg) 📚 8 studies — no high-quality reviews

RDA 2.3mg This product: 1mg UL 11mg

Chromium

100 mcg (85% DV)

✅ 2.9× RDA — within safe limits 📚 197 studies (Tier A: 1, B: 55)

RDA 0.035mg This product: 0.1mg

L-Lysine

17.5 mg

📊 Market median: 500.0mg (159 products)

Median 500.0mg This product: 17.5mg

L-Threonine

17.5 mg

Isoflavones

25 mg

Flaxseed

1.84 Gram(s)

📊 Market median: 1000.0mg (212 products) 📚 12 studies (Tier A: 0, B: 3)

This product: 1.84mg

Choline

450 mg

✅ Within RDA (0.8× RDA of 550 mg) 📚 36 studies (Tier A: 1, B: 7)

RDA 550mg This product: 450mg UL 3500mg

Turmeric Rhizome Extract

210 mg

📊 Market median: 450.0mg (254 products) 📚 240 studies (Tier A: 0, B: 100)

This product: 210mg

Other Ingredients

Rice Protein concentrate Rice syrup solids Fructose Olive Oil Magnesium Citrate flaxseed Natural flavors Choline Bitartrate Calcium Citrate Dipotassium Phosphate Xanthan Gum D-Alpha-Tocopheryl Succinate curcumin powder Guar Gum Ascorbic Acid Pyridoxine Hydrochloride Zinc Gluconate pueraria root extract Chromium Polynicotinate Ferrous Fumarate L-Lysine L-Threonine Niacinamide Copper Gluconate Calcium D-Pantothenate Beta-Carotene Thiamine Hydrochloride Riboflavin Folic Acid Retinyl Palmitate Biotin Potassium Iodide Cyanocobalamin Cholecalciferol Ingredients

Label Claims — Verification

❓ All Other

All Other (99% of products) Structure/Function (85% of products) Nutrient (54% of products) Approved Health (3% of products)

Target Groups

Adult Female (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Directions: Blend or shake about 2 level scoops (46 grams) of Estrium into 8 ounces of water, juice, or soy, almond, rice, or organic cow's milk twice daily, or as directed by your health care practitioner.

⚠️ Warnings & Precautions

TAMPER EVIDENT: Do not use if safety seal is missing or broken.

NOTICE: THIS PRODUCT IS TO BE USED UNDER THE DIRECT SUPERVISION OF A PHYSICIAN OR OTHER LICENSED HEALTHCARE PRACTITIONER. DO NOT ENGAGE IN ANY DIET SUPPLYING LESS THAN 800 CALORIES PER DAY WITHOUT MEDICAL SUPERVISION

IMPORTANT WARNING: This product has been formulated to nutritionally support female patients who have symptoms associated with their hormone cycles.

It has not been tested for interactions with oral contraceptive medications, and the effectiveness of oral contraceptives for birth control cannot be ensured during use of Estrium.

Please discuss this important concern with your healthcare practitioner.

WARNING: Excess vitamin A intake may be toxic and may increase the risk of birth defects. Pregnant women and women who may become pregnant should not exceed 5000 IU of preformed vitamin A (retinyl palmitate) per day.

🧪 Formulation Notes

This product is Gluten Free.

Formulated to Exclude: Wheat, egg, stimulants, dairy products, nuts, tree nuts, fish, crustacean shellfish, colors, artificial sweeteners, and artificial flavors.

Additional Information

Information per Serving:

1538591F4 PROD. ESTRM

Genetic Potential Through Nutrition

NUTRITIONAL SUPPORT FOR SYMPTOMS RELATED TO PREMENSTRUAL SYNDROME

Natural Tropical Mango Flavor with Other Natural Flavors

Estrium provides a specialized blend of macronutrients with all essential vitamins and minerals, along with non-soy phytoestrogens, antioxidants, and flaxseed hull (equal to approximately one tablespoon of whole flaxseed) that were specially selected for their ability to promote healthy estrogen metabolism and healthy hormone balance.

Contents sold by weight, not volume. Some settling may occur during shipping and handling. Serving size is measured by weight. A scoop is included for your convenience. The amount of product contained in two scoops may be above or below 45 grams due to variations in handling and product density.

Storage: Keep tightly closed in a cool, dry place.

Medical Food

Product Details

UPC / SKU 7 55571 91668 6

DSLD Entry Date 2013-10-25

Product Type Other Combinations

Form Powder

Brand Metagenics

DSLD ID 26809

Data Updated 2026-04-11

Research Evidence

849 Research Sources

56 Avg Quality Score

450 Meta Analysis

152 Rct

137 Systematic Review

73 Clinical Trial

11 Regulatory Source

7 Other

7 Guideline

3 Openfda Safety

2 Cochrane Review

2 Observational

A Phosphate binders for preventing and treating chronic kidney disease-mineral and bone disorder (CKD-MBD)

Meta Analysis The Cochrane database of systematic reviews 2018

PubMed DOI Cochrane

A Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes

Meta Analysis The Cochrane database of systematic reviews 2024

PubMed DOI Cochrane

A Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes

Meta Analysis The Cochrane database of systematic reviews 2015

PubMed DOI Cochrane

A Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life

Meta Analysis The Cochrane database of systematic reviews 2018

PubMed DOI Cochrane

A Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems

Meta Analysis The Cochrane database of systematic reviews 2025

PubMed DOI Cochrane

A Dietary calcium supplementation for preventing colorectal cancer and adenomatous polyps

Systematic Review The Cochrane database of systematic reviews 2008

PubMed DOI Cochrane

A Calcium and vitamin D for increasing bone mineral density in premenopausal women

Systematic Review The Cochrane database of systematic reviews 2023

PubMed DOI Cochrane

A Dietary sodium, sodium-to-potassium ratio, and risk of stroke: A systematic review and nonlinear dose-response meta-analysis

Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2019

PubMed DOI

A The association between circulating magnesium and clinically relevant outcomes in patients with chronic kidney disease: A systematic review and meta-analysis

Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2021

PubMed DOI

A Calcium channel blockers versus other classes of drugs for hypertension

Systematic Review The Cochrane database of systematic reviews 2021

PubMed DOI

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