OPC-3 Multivitamin Activated B-Complex Calcium Plus

product on market Powder Isotonix 🟢 Safety: 98/100
Brand: Isotonix
🟢 98/100

This product looks safe

  • Niacin: 60mg is 1.7× the Tolerable Upper Intake Level (35mg)
  • Folate: 648mg is 648.0× the Tolerable Upper Intake Level (1.0mg)
  • 59% of ingredients have research evidence
D Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Niacin: 60mg is 1.7× the Tolerable Upper Intake Level (35mg)
⚠️ Folate: 648mg is 648.0× the Tolerable Upper Intake Level (1.0mg)

Label Data

13.3 Gram(s) Serving Size
30 Servings
Other Combinations Product Type
59% Evidence Coverage

Supplement Facts — Evidence Check

Calories
25 Calorie(s)
Total Carbohydrates
6 Gram(s) (2% DV)
Vitamin A
3000 mcg RAE (333% DV)
Vitamin C
179 mg (199% DV)
37.5 mcg (188% DV)
✅ 2.5× RDA — within safe limits 📚 604 studies (Tier A: 16, B: 251)
RDA 0.015mg This product: 0.0375mg UL 0.1mg
54.3 mg (362% DV)
📊 3.6× RDA — above typical dose (UL: 1000 mg) 📚 177 studies (Tier A: 3, B: 90)
RDA 15mg This product: 54.3mg UL 1000mg
4.6 mg (383% DV)
📊 3.8× RDA — above typical dose 📚 76 studies (Tier A: 0, B: 33)
RDA 1.2mg This product: 4.6mg
7.8 mg (600% DV)
📊 6.0× RDA — above typical dose 📚 12 studies (Tier A: 0, B: 1)
RDA 1.3mg This product: 7.8mg
60 mg NE (375% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 1.7× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 60mg UL 35mg
10 mg (588% DV)
📊 7.7× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 10mg UL 100mg
648 mcg DFE (162% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 648.0× (UL: 1.0 mg) 📚 225 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 648mg UL 1.0mg
195 mcg (8125% DV)
📊 81.3× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 0.195mg
600 mcg (2000% DV)
📊 20.0× RDA — above typical dose 📚 26 studies (Tier A: 0, B: 11)
RDA 0.03mg This product: 0.6mg
40 mg (800% DV)
📊 8.0× RDA — above typical dose 📚 1 studies — no high-quality reviews
RDA 5mg This product: 40mg
Calcium
467 mg (36% DV)
150 mcg (100% DV)
✅ Within RDA (1.0× RDA of 0.15 mg) 📚 243 studies (Tier A: 4, B: 133)
RDA 0.15mg This product: 0.15mg UL 1.1mg
125 mg (30% DV)
📊 Market median: 4002.0mg (1 products) 📚 20 studies (Tier A: 0, B: 2)
This product: 125mg
7.5 mg (68% DV)
✅ Within RDA (0.7× RDA of 11 mg) 📚 258 studies (Tier A: 6, B: 134)
RDA 11mg This product: 7.5mg UL 40mg
55 mcg (100% DV)
✅ Within RDA (1.0× RDA of 0.055 mg) 📚 172 studies (Tier A: 0, B: 67)
RDA 0.055mg This product: 0.055mg UL 0.4mg
100 mcg (11% DV)
✅ Within RDA (0.1× RDA of 0.9 mg) 📚 36 studies (Tier A: 0, B: 11)
RDA 0.9mg This product: 0.1mg UL 10mg
2.5 mg (101% DV)
✅ 1.1× RDA — within safe limits 📚 8 studies — no high-quality reviews
RDA 2.3mg This product: 2.5mg UL 11mg
120 mcg (343% DV)
📊 3.4× RDA — above typical dose 📚 197 studies (Tier A: 1, B: 55)
RDA 0.035mg This product: 0.12mg
Potassium
406 mg (9% DV)
25 mg
📊 Market median: 100.0mg (284 products) 📚 10 studies (Tier A: 0, B: 4)
This product: 25mg
Red Wine extract
25 mg
Pine bark extract
25 mg
25 mg
📊 Market median: 100.0mg (120 products)
Median 100.0mg This product: 25mg
25 mg
📊 Market median: 500.0mg (283 products) 📚 173 studies (Tier A: 0, B: 62)
This product: 25mg
0.5 mg
📊 Market median: 3.0mg (58 products) 📚 2 studies — no high-quality reviews
This product: 0.5mg UL 20mg

Other Ingredients

Fructose Citric Acid Glucose Maltodextrin Orange flavor Orange juice powder Malic Acid Mango flavor Silicon Dioxide Passion Fruit flavor Rebaudioside A Lo Han (fruit) extract Apple Fiber Food Starch Apple Pectin Vanilla flavor Lemon Flavor Lime flavor

Label Claims — Verification

❓ Nutrient
❓ All Other
❓ Structure/Function
All Other (99% of products) Structure/Function (76% of products) Nutrient (58% of products)

Target Groups

Vegetarian Adult (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Directions for use: Pour contents of packet into a cup. Add 8 fl oz. of water into the cup and stir. As a dietary supplement, take once daily or as directed by your healthcare provider. Maximum absorption occurs when taken on an empty stomach. This product is isotonic only if the specified amounts of powder and water are used.

Directions for use: Pour contents of packet into a glass.

⚠️ Warnings & Precautions

Warning: If you are currently using any prescription drugs, have an ongoing medical condition or are pregnant or breastfeeding, you should consult your healthcare provider before using this product.

Keep out of the reach of children.

Do not use if packet has been opened.

🧪 Formulation Notes

Contains 100% or more of the recommended daily value of essential vitamins and minerals to help supplement deficiencies in diet

Combats free radicals Increases energy Promotes strong bones and healthy teeth Helps decrease stress and improve mood

This vegetarian product contains no wheat, soy, yeast, gluten, artificial flavor, salt, preservatives or milk.

This vegetarian product contains no wheat, soy, yeast, gluten, artificial flavor, salt, preservatives or milk.

Additional Information

The world's most advanced nutraceuticals

30 - 0.47 oz (13.3 g) Packet Net Weight: 14.1 oz (399 g)

Store in a cool, dry place.

Product Details

DSLD Entry Date 2020-04-23
Product Type Other Combinations
Form Powder
Brand Isotonix
DSLD ID 218132
Data Updated 2026-04-11

Research Evidence

337 Research Sources
54 Avg Quality Score
161 Meta Analysis
68 Systematic Review
51 Rct
48 Clinical Trial
2 Other
2 Regulatory Source
1 Narrative Review
1 Cochrane Review
1 Guideline
1 Openfda Safety
A Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age
Meta Analysis The Cochrane database of systematic reviews 2017
PubMed DOI Cochrane
A Vitamin A supplementation for the prevention of morbidity and mortality in infants six months of age or less
Meta Analysis The Cochrane database of systematic reviews 2011
PubMed DOI Cochrane
A Vitamin A supplementation for reducing the risk of mother-to-child transmission of HIV infection
Meta Analysis The Cochrane database of systematic reviews 2011
PubMed DOI Cochrane
A Vitamin A supplements for preventing mortality, illness, and blindness in children aged under 5: systematic review and meta-analysis
Meta Analysis BMJ (Clinical research ed.) 2011
PubMed DOI
A Fortification of staple foods with vitamin A for vitamin A deficiency
Systematic Review The Cochrane database of systematic reviews 2019
PubMed DOI Cochrane
A Vitamin A supplementation for the prevention of morbidity and mortality in infants one to six months of age
Narrative Review The Cochrane database of systematic reviews 2016
PubMed DOI Cochrane
A Vitamin A and fish oils for preventing the progression of retinitis pigmentosa
Meta Analysis The Cochrane database of systematic reviews 2020
PubMed DOI
A Exercise training-induced changes in exerkine concentrations may be relevant to the metabolic control of type 2 diabetes mellitus patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Journal of sport and health science 2023
PubMed DOI
A Food fortification with multiple micronutrients: impact on health outcomes in general population
Meta Analysis The Cochrane database of systematic reviews 2019
PubMed DOI
A Oral vitamin A supplements to prevent acute upper respiratory tract infections in children up to seven years of age
Meta Analysis The Cochrane database of systematic reviews 2024
PubMed DOI
View all evidence for Vitamin A →

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