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OPC-3 Multivitamin Activated B-Complex Calcium Plus

product on market Powder Isotonix Safety: 98/100
98/100

This product looks safe

  • Niacin: 60mg is 1.7× the Tolerable Upper Intake Level (35mg)
  • Folate: 648mg is 648.0× the Tolerable Upper Intake Level (1.0mg)
  • 59% of ingredients have research evidence
D Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

This formula contains vitamins A, C, and D3, which are supported by strong evidence for maintaining immune function and bone health. However, the overall evidence coverage for this specific ingredient profile is very low at 0.586%. The product maintains a high safety score of 98/100.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Niacin: 60mg is 1.7× the Tolerable Upper Intake Level (35mg)

Folate: 648mg is 648.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for OPC-3 Multivitamin Activated B-Complex Calcium Plus
Open Full PDF View on NIH DSLD →
Details

Label Data

13.3 Gram(s)
Serving Size
30
Servings
Other Combinations
Product Type
59%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Calories
25 Calorie(s)
Total Carbohydrates
6 Gram(s) (2% DV)
Vitamin A
3000 mcg RAE (333% DV)
Vitamin C
179 mg (199% DV)
37.5 mcg (188% DV)
2.5× RDA — within safe limits 608 studies (A:16, B:251)
54.3 mg (362% DV)
3.6× RDA — above typical dose (UL: 1000 mg) 179 studies (A:3, B:90)
4.6 mg (383% DV)
3.8× RDA — above typical dose 76 studies (A:0, B:33)
7.8 mg (600% DV)
6.0× RDA — above typical dose 13 studies (A:0, B:1)
60 mg NE (375% DV)
Exceeds UL by 1.7× (UL: 35 mg) 196 studies (A:5, B:63)
10 mg (588% DV)
7.7× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
648 mcg DFE (162% DV)
Exceeds UL by 648.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
195 mcg (8125% DV)
81.3× RDA — above typical dose 139 studies (A:1, B:44)
600 mcg (2000% DV)
20.0× RDA — above typical dose 27 studies (A:0, B:11)
40 mg (800% DV)
8.0× RDA — above typical dose 2 studies — no high-quality reviews
Calcium
467 mg (36% DV)
150 mcg (100% DV)
Within RDA (1.0× RDA) 245 studies (A:4, B:133)
125 mg (30% DV)
Within RDA (0.3× RDA) 316 studies (A:8, B:159)
7.5 mg (68% DV)
Within RDA (0.7× RDA) 263 studies (A:6, B:134)
55 mcg (100% DV)
Within RDA (1.0× RDA) 173 studies (A:0, B:67)
100 mcg (11% DV)
Within RDA (0.1× RDA) 37 studies (A:0, B:11)
2.5 mg (101% DV)
1.1× RDA — within safe limits 9 studies — no high-quality reviews
120 mcg (343% DV)
3.4× RDA — above typical dose 199 studies (A:1, B:55)
Potassium
406 mg (9% DV)
Market median: 100.0mg (284 products) 10 studies (A:0, B:4)
Red Wine extract
25 mg
Pine bark extract
25 mg
Market median: 100.0mg (120 products)
Market median: 500.0mg (283 products) 174 studies (A:0, B:62)
0.5 mg
Market median: 3.0mg (58 products) 3 studies — no high-quality reviews

Other Ingredients

Fructose Citric Acid Glucose Maltodextrin Orange flavor Orange juice powder Malic Acid Mango flavor Silicon Dioxide Passion Fruit flavor Rebaudioside A Lo Han (fruit) extract Apple Fiber Food Starch Apple Pectin Vanilla flavor Lemon Flavor Lime flavor
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions for use: Pour contents of packet into a cup. Add 8 fl oz. of water into the cup and stir. As a dietary supplement, take once daily or as directed by your healthcare provider. Maximum absorption occurs when taken on an empty stomach. This product is isotonic only if the specified amounts of powder and water are used.

Directions for use: Pour contents of packet into a glass.

Warnings & Precautions

Warning: If you are currently using any prescription drugs, have an ongoing medical condition or are pregnant or breastfeeding, you should consult your healthcare provider before using this product.

Keep out of the reach of children.

Do not use if packet has been opened.

Formulation Notes

Contains 100% or more of the recommended daily value of essential vitamins and minerals to help supplement deficiencies in diet

Combats free radicals Increases energy Promotes strong bones and healthy teeth Helps decrease stress and improve mood

This vegetarian product contains no wheat, soy, yeast, gluten, artificial flavor, salt, preservatives or milk.

This vegetarian product contains no wheat, soy, yeast, gluten, artificial flavor, salt, preservatives or milk.

Additional Information

The world's most advanced nutraceuticals

30 - 0.47 oz (13.3 g) Packet Net Weight: 14.1 oz (399 g)

Store in a cool, dry place.

Metadata

Product Details

DSLD Entry Date2020-04-23
Product TypeOther Combinations
FormPowder
BrandIsotonix
DSLD ID218132
Data Updated2026-04-11
Research

Research Evidence

337
Research Sources
54
Avg Quality
161
Meta Analysis
68
Systematic Review
51
Rct
48
Clinical Trial
2
Other
2
Regulatory Source
1
Narrative Review
1
Cochrane Review
1
Guideline
1
Openfda Safety
A Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Vitamin A supplementation for the prevention of morbidity and mortality in infants six months of age or less
Meta Analysis The Cochrane database of systematic reviews 2011 PubMed DOI
A Vitamin A supplementation for reducing the risk of mother-to-child transmission of HIV infection
Meta Analysis The Cochrane database of systematic reviews 2011 PubMed DOI
A Vitamin A supplements for preventing mortality, illness, and blindness in children aged under 5: systematic review and meta-analysis
Meta Analysis BMJ (Clinical research ed.) 2011 PubMed DOI
A Fortification of staple foods with vitamin A for vitamin A deficiency
Systematic Review The Cochrane database of systematic reviews 2019 PubMed DOI
A Vitamin A supplementation for the prevention of morbidity and mortality in infants one to six months of age
Narrative Review The Cochrane database of systematic reviews 2016 PubMed DOI
A Vitamin A and fish oils for preventing the progression of retinitis pigmentosa
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
A Exercise training-induced changes in exerkine concentrations may be relevant to the metabolic control of type 2 diabetes mellitus patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Journal of sport and health science 2023 PubMed DOI
A Food fortification with multiple micronutrients: impact on health outcomes in general population
Meta Analysis The Cochrane database of systematic reviews 2019 PubMed DOI
A Oral vitamin A supplements to prevent acute upper respiratory tract infections in children up to seven years of age
Meta Analysis The Cochrane database of systematic reviews 2024 PubMed DOI
View all evidence for Vitamin A →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.