Is 0.8 mcg of Vitamin D safe?

Yes — this is 0.1× the recommended daily intake of 0.015 mg, which is within safe limits.

Is 44.8 mg of Vitamin E safe?

Yes — this is 3.0× the recommended daily intake of 15 mg, which is within safe limits.

Clear Change Daily Essentials by Metagenics — Ingredients, Evidence & Safety

🟢 98/100

This product looks safe

Niacin: 398mg is 11.4× the Tolerable Upper Intake Level (35mg)
Folate: 1135mg is 1135.0× the Tolerable Upper Intake Level (1.0mg)
60% of ingredients have research evidence

D Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

This profile contains vitamins A, C, D, and E, which are supported by strong evidence for maintaining immune function and cellular health. These nutrients act as antioxidants and essential regulators of biological processes. However, the overall evidence coverage for this specific formulation is limited.

AI-generated summary based on research evidence. Not medical advice.

Product Label

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Safety Alerts

⚠️ Niacin: 398mg is 11.4× the Tolerable Upper Intake Level (35mg)

⚠️ Folate: 1135mg is 1135.0× the Tolerable Upper Intake Level (1.0mg)

Label Data

1 Packet(s) Serving Size

30 Servings

Other Combinations Product Type

60% Evidence Coverage

Supplement Facts — Evidence Check

Total Carbohydrates

1 Gram(s) (1% DV)

Vitamin A

750 mcg (83% DV)

Vitamin C

383 mg (426% DV)

Vitamin D

0.8 mcg (4% DV)

✅ Within RDA (0.1× RDA of 0.015 mg) 📚 608 studies (Tier A: 16, B: 251)

RDA 0.015mg This product: 0.0008mg UL 0.1mg

Vitamin E

44.8 mg (299% DV)

✅ 3.0× RDA — within safe limits 📚 179 studies (Tier A: 3, B: 90)

RDA 15mg This product: 44.8mg UL 1000mg

Thiamine

10 mg (833% DV)

📊 8.3× RDA — above typical dose 📚 76 studies (Tier A: 0, B: 33)

RDA 1.2mg This product: 10mg

Riboflavin

5 mg (385% DV)

📊 3.8× RDA — above typical dose 📚 13 studies (Tier A: 0, B: 1)

RDA 1.3mg This product: 5mg

Niacin

398 mg (2488% DV)

⚠️ Exceeds Tolerable Upper Intake Level by 11.4× (UL: 35 mg) 📚 196 studies (Tier A: 5, B: 63)

RDA 14mg This product: 398mg UL 35mg

Vitamin B6

27 mg (1588% DV)

📊 20.8× RDA — above typical dose (UL: 100 mg) 📚 114 studies (Tier A: 3, B: 35)

RDA 1.3mg This product: 27mg UL 100mg

Folate

1135 mcg DFE (284% DV)

⚠️ Exceeds Tolerable Upper Intake Level by 1135.0× (UL: 1.0 mg) 📚 226 studies (Tier A: 10, B: 105)

RDA 0.4mg This product: 1135mg UL 1.0mg

Vitamin B12

158 mcg (6583% DV)

📊 65.8× RDA — above typical dose 📚 139 studies (Tier A: 1, B: 44)

RDA 0.0024mg This product: 0.158mg

Biotin

66 mcg (220% DV)

✅ 2.2× RDA — within safe limits 📚 27 studies (Tier A: 0, B: 11)

RDA 0.03mg This product: 0.066mg

Pantothenic Acid

33 mg (660% DV)

📊 6.6× RDA — above typical dose 📚 2 studies — no high-quality reviews

RDA 5mg This product: 33mg

Zinc

6.5 mg (59% DV)

✅ Within RDA (0.6× RDA of 11 mg) 📚 263 studies (Tier A: 6, B: 134)

RDA 11mg This product: 6.5mg UL 40mg

Selenium

87 mcg (158% DV)

✅ 1.6× RDA — within safe limits 📚 173 studies (Tier A: 0, B: 67)

RDA 0.055mg This product: 0.087mg UL 0.4mg

Copper

0.65 mg (72% DV)

✅ Within RDA (0.7× RDA of 0.9 mg) 📚 37 studies (Tier A: 0, B: 11)

RDA 0.9mg This product: 0.65mg UL 10mg

Manganese

1.65 mg (72% DV)

✅ Within RDA (0.7× RDA of 2.3 mg) 📚 9 studies — no high-quality reviews

RDA 2.3mg This product: 1.65mg UL 11mg

Molybdenum

66 mcg (147% DV)

✅ 1.5× RDA — within safe limits 📚 3 studies — no high-quality reviews

RDA 0.045mg This product: 0.066mg UL 2mg

Sodium

40 mg (2% DV)

N-Acetyl L-Cysteine

642 mg

Chinese Salvia

200 mg

📊 Market median: 500.0mg (82 products) 📚 19 studies (Tier A: 1, B: 6)

This product: 200mg

Cordyceps Mycelium Extract

200 mg

Artichoke Leaf Extract

167 mg

Watercress Aerial Parts Extract

133 mg

Taurine

117 mg

📊 Market median: 500.0mg (180 products) 📚 5 studies (Tier A: 0, B: 1)

This product: 117mg

Sodium Sulfate

100 mg

📊 Market median: 4002.0mg (1 products) 📚 21 studies (Tier A: 0, B: 2)

This product: 100mg

Pomegranate whole fruit extract

87.5 mg

📊 Market median: 250.0mg (182 products) 📚 10 studies (Tier A: 0, B: 2)

This product: 87.5mg

decaffeinated Green Tea leaf extract

56 mg

📊 Market median: 260.0mg (249 products) 📚 158 studies (Tier A: 4, B: 61)

This product: 56mg

Silymarin

50 mg

📊 Market median: 250.0mg (562 products) 📚 55 studies (Tier A: 0, B: 19)

This product: 50mg

Broccoli Seed Extract

19.25 mg

Other Ingredients

Hydroxypropyl Methylcellulose Microcrystalline Cellulose Magnesium Stearate Silica Microcrystalline Cellulose Cellulose Stearic Acid Silica Hypromellose Medium Chain Triglyceride Hydroxypropyl Cellulose Hypromellose Sodium Copper Chlorophyllin Microcrystalline Cellulose Magnesium Stearate

Label Claims — Verification

❓ Nutrient

❓ All Other

❓ Structure/Function

All Other (99% of products) Structure/Function (76% of products) Nutrient (58% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

Directions: Take one packet daily for one to two months or as directed by your healthcare practitioner.

⚠️ Warnings & Precautions

Warning: Do not use if taking blood thinning medications, antihypertensive medications, hypoglycemic medications and insulin, digoxin or nitroglycerin, or before surgery. Pregnant women and women who may become pregnant should not exceed 3,000 mcg of preformed vitamin A (retinyl palmitate) per day. Caution: If pregnant or nursing, or if taking medications, consult your healthcare practitioner before use.

Excessive vitamin A intake may increase the risk of birth defects. Tamper evident: Do not use if package is torn or open.

🧪 Formulation Notes

Clear Change Daily Essential is a premium packet containing 3 nutritional supplements designed to complement your daily foundation nutrition program and support daily detoxification following the Clear Change Metabolic Detoxification Program. This 1-month program features AdvaClear, GlutaClear, and Renagen DTX for targeted, daily support.

Each once-daily packet provides: Bifunctional detoxification support: AdvaClear supports vitality and health by supporting balanced activity of the Phase 1 and Phase 2 detoxification pathways. This formula provides methylated vitamin B12 and folic acid along with nutrients designed to enhance the activities of several liver detoxification enzymes. Antioxidant protection & detoxification support: GlutaClear features a blend of key ingredients, including antioxidant vitamins, designed to help boost the body's production of glutathione. Glutathione plays an important role in protecting the body against oxidative stress and protecting cellular health. Kidney health: Renagen DTX is a specific blend of nutrients and traditional herbs designed to support healthy kidney function.

The Metagenics Difference Metagentics is one of the few professional nutraceutical companies that formulates and evaluates nutritional products in clinical practice. Each Clear Change Daily Essential formula is science based and delivers optimized, targeted health support.

Certified Gluten Free GFCO.org (Gluten-Free Certification Organization)

Each packet contains: 2 AdvaClear capsules (light brown), 1 GlutaClear tablet (white), and 1 Renagen DTX capsule (green).

Products included are non-GMO and gluten-free.

Clear Change Daily Essential provides advanced nutritional support for: Detoxification Bifunctional support Cellular protection Cellular health Antioxidant support Overall wellness Advanced detoxification support Practitioner recommended

Gluten-free Non-GMO

Additional Information

Not labeled for individual sale For product information call: US 800-692-940 0 Canada 800-268-6200 NPN: 80062144, 80049046, 80050486 1550330A

For more information, visit ClearChangeProgram.com Please Recycle

Certified Gluten Free GFCO.org (Gluten-Free Certification Organization)

Storage: Keep in a cool, dry place.

Product Details

UPC / SKU 7 55571 93967 8

DSLD Entry Date 2025-02-23

Product Type Other Combinations

Form Other (e.g. tea bag)

Brand Metagenics

DSLD ID 325700

Data Updated 2026-04-11

Research Evidence

337 Research Sources

54 Avg Quality Score

161 Meta Analysis

68 Systematic Review

51 Rct

48 Clinical Trial

2 Other

2 Regulatory Source

1 Narrative Review

1 Cochrane Review

1 Guideline

1 Openfda Safety

A Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age

Meta Analysis The Cochrane database of systematic reviews 2017

PubMed DOI Cochrane

A Vitamin A supplementation for the prevention of morbidity and mortality in infants six months of age or less

Meta Analysis The Cochrane database of systematic reviews 2011

PubMed DOI Cochrane

A Vitamin A supplementation for reducing the risk of mother-to-child transmission of HIV infection

Meta Analysis The Cochrane database of systematic reviews 2011

PubMed DOI Cochrane

A Vitamin A supplements for preventing mortality, illness, and blindness in children aged under 5: systematic review and meta-analysis

Meta Analysis BMJ (Clinical research ed.) 2011

PubMed DOI

A Fortification of staple foods with vitamin A for vitamin A deficiency

Systematic Review The Cochrane database of systematic reviews 2019

PubMed DOI Cochrane

A Vitamin A supplementation for the prevention of morbidity and mortality in infants one to six months of age

Narrative Review The Cochrane database of systematic reviews 2016

PubMed DOI Cochrane

A Vitamin A and fish oils for preventing the progression of retinitis pigmentosa

Meta Analysis The Cochrane database of systematic reviews 2020

PubMed DOI

A Exercise training-induced changes in exerkine concentrations may be relevant to the metabolic control of type 2 diabetes mellitus patients: A systematic review and meta-analysis of randomized controlled trials

Meta Analysis Journal of sport and health science 2023

PubMed DOI

A Food fortification with multiple micronutrients: impact on health outcomes in general population

Meta Analysis The Cochrane database of systematic reviews 2019

PubMed DOI

A Oral vitamin A supplements to prevent acute upper respiratory tract infections in children up to seven years of age

Meta Analysis The Cochrane database of systematic reviews 2024

PubMed DOI

View all evidence for Vitamin A →