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AdvaClear

product on market Capsule Metagenics Safety: 99/100
99/100

This product looks safe

  • Folate: 445mg is 445.0× the Tolerable Upper Intake Level (1.0mg)
  • 69% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

This profile contains vitamins A, C, D, E, and thiamine, which are supported by strong evidence for maintaining immune function and cellular health. These nutrients act as essential antioxidants and cofactors in metabolic processes. The overall safety profile is high, though evidence coverage for this specific combination is limited.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folate: 445mg is 445.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for AdvaClear
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Capsule(s)
Serving Size
21
Servings
Other Combinations
Product Type
69%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Vitamin A
750 mcg (83% DV)
Vitamin C
133 mg (148% DV)
0.8 mcg (4% DV)
Within RDA (0.1× RDA) 608 studies (A:16, B:251)
44.6 mg (297% DV)
3.0× RDA — within safe limits 179 studies (A:3, B:90)
10 mg (833% DV)
8.3× RDA — above typical dose 76 studies (A:0, B:33)
5 mg (385% DV)
3.8× RDA — above typical dose 13 studies (A:0, B:1)
23.3 mg (146% DV)
1.7× RDA — within safe limits 196 studies (A:5, B:63)
16.66 mg (980% DV)
12.8× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
445 mcg DFE (111% DV)
Exceeds UL by 445.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
33.4 mcg (1392% DV)
13.9× RDA — above typical dose 139 studies (A:1, B:44)
66 mcg (220% DV)
2.2× RDA — within safe limits 27 studies (A:0, B:11)
33.3 mg (666% DV)
6.7× RDA — above typical dose 2 studies — no high-quality reviews
6.5 mg (59% DV)
Within RDA (0.6× RDA) 263 studies (A:6, B:134)
50 mcg (91% DV)
Within RDA (0.9× RDA) 173 studies (A:0, B:67)
0.66 mg (73% DV)
Within RDA (0.7× RDA) 37 studies (A:0, B:11)
1.66 mg (72% DV)
Within RDA (0.7× RDA) 9 studies — no high-quality reviews
66 mcg (147% DV)
1.5× RDA — within safe limits 3 studies — no high-quality reviews
Sodium
40 mg (2% DV)
Artichoke Leaf Extract
167 mg
Watercress Aerial Parts Extract
133 mg
117 mg
Market median: 500.0mg (180 products) 5 studies (A:0, B:1)
Market median: 4002.0mg (1 products) 21 studies (A:0, B:2)
Market median: 250.0mg (182 products) 10 studies (A:0, B:2)
Market median: 600.0mg (7 products) 39 studies (A:2, B:13)
Market median: 260.0mg (249 products) 158 studies (A:4, B:61)
50 mg
Market median: 250.0mg (562 products) 55 studies (A:0, B:19)

Other Ingredients

Hydroxypropyl Methylcellulose Microcrystalline Cellulose Magnesium Stearate Silicon Dioxide
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: Take two capsules once daily or as directed by you healthcare practitioner.

Warnings & Precautions

Warning: Excess vitamin A intake may increase the risk of birth defects. Pregnant women and women who may become pregnant should not exceed 3,000 mcg of preformed vitamin A (retinyl palmitate) per day. Caution: If pregnant or nursing, or taking medications, consult your healthcare practitioner before use.

Keep out of the reach of children.

Formulation Notes

AdvaClear supports daily detoxification for optimal vitality and health. This formula provides methylated B12 and folate along with bifunctional nutritional support designed to enhance the activities of several liver detoxification enzymes and support Phase I and Phase II detoxification pathways.

This product is non-GMO and gluten-free.

GFCO.org (Gluten-Free Certification Organization)

Daily support for balanced detoxification

Vegetarian capsule

Additional Information

Storage: Keep tightly closed in a cool, dry place.

GFCO.org (Gluten-Free Certification Organization)

Practitioner Recommended

Metadata

Product Details

UPC / SKU7 55571 93050 7
DSLD Entry Date2025-03-25
Product TypeOther Combinations
FormCapsule
BrandMetagenics
DSLD ID323365
Data Updated2026-04-11
Research

Research Evidence

337
Research Sources
54
Avg Quality
161
Meta Analysis
68
Systematic Review
51
Rct
48
Clinical Trial
2
Other
2
Regulatory Source
1
Narrative Review
1
Cochrane Review
1
Guideline
1
Openfda Safety
A Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Vitamin A supplementation for the prevention of morbidity and mortality in infants six months of age or less
Meta Analysis The Cochrane database of systematic reviews 2011 PubMed DOI
A Vitamin A supplementation for reducing the risk of mother-to-child transmission of HIV infection
Meta Analysis The Cochrane database of systematic reviews 2011 PubMed DOI
A Vitamin A supplements for preventing mortality, illness, and blindness in children aged under 5: systematic review and meta-analysis
Meta Analysis BMJ (Clinical research ed.) 2011 PubMed DOI
A Fortification of staple foods with vitamin A for vitamin A deficiency
Systematic Review The Cochrane database of systematic reviews 2019 PubMed DOI
A Vitamin A supplementation for the prevention of morbidity and mortality in infants one to six months of age
Narrative Review The Cochrane database of systematic reviews 2016 PubMed DOI
A Vitamin A and fish oils for preventing the progression of retinitis pigmentosa
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
A Exercise training-induced changes in exerkine concentrations may be relevant to the metabolic control of type 2 diabetes mellitus patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Journal of sport and health science 2023 PubMed DOI
A Food fortification with multiple micronutrients: impact on health outcomes in general population
Meta Analysis The Cochrane database of systematic reviews 2019 PubMed DOI
A Oral vitamin A supplements to prevent acute upper respiratory tract infections in children up to seven years of age
Meta Analysis The Cochrane database of systematic reviews 2024 PubMed DOI
View all evidence for Vitamin A →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.