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System-Six

product on market Softgel Capsule Irwin Naturals Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 50% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

The listed top ingredients consist of basic macronutrients, including fats, carbohydrates, and proteins, which provide foundational energy and structural support for the body. There is strong evidence supporting the general roles of these nutrients in human health. However, the evidence coverage for this specific formulation is limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for System-Six
Open Full PDF View on NIH DSLD →
Details

Label Data

3 Liquid Softgel(s)
Serving Size
20
Servings
Other Combinations
Product Type
50%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Calories
25 Calorie(s)
Total Fat
1.5 Gram(s) (2% DV)
Cholesterol
5 mg (2% DV)
Total Carbohydrates
2 Gram(s) (1% DV)
Protein
2 Gram(s)
Vitamin C
8 mg (9% DV)
4.5 mg (30% DV)
Within RDA (0.3× RDA) 179 studies (A:3, B:90)
0.5 mg (42% DV)
Within RDA (0.4× RDA) 76 studies (A:0, B:33)
0.5 mg (38% DV)
Within RDA (0.4× RDA) 13 studies (A:0, B:1)
7 mg (44% DV)
Within RDA (0.5× RDA) 196 studies (A:5, B:63)
7 mcg (292% DV)
2.9× RDA — within safe limits 139 studies (A:1, B:44)
15 mg (300% DV)
3.0× RDA — within safe limits 2 studies — no high-quality reviews
20 mg (3% DV)
Market median: 125.0mg (294 products) 38 studies (A:1, B:7)
17 mcg (31% DV)
Within RDA (0.3× RDA) 173 studies (A:0, B:67)
100 mcg (286% DV)
2.9× RDA — within safe limits 199 studies (A:1, B:55)
1800 mg
Market median: 750.0mg (447 products) 393 studies (A:18, B:204)
Market median: 600.0mg (321 products) 5 studies — no high-quality reviews
White Tea Leaf Extract
300 mg
Market median: 260.0mg (249 products) 158 studies (A:4, B:61)
Market median: 650.0mg (87 products) 1 studies — no high-quality reviews
80 mg
Market median: 500.0mg (861 products) 61 studies (A:4, B:13)
50 mg
Market median: 200.0mg (358 products) 9 studies (A:0, B:2)
40 mg
Market median: 500.0mg (223 products) 24 studies (A:0, B:1)
Cayenne, Powder
20 mg
Market median: 250.0mg (337 products) 127 studies (A:1, B:41)
Market median: 495.0mg (70 products)
20 mg
Market median: 550.0mg (217 products) 29 studies (A:0, B:5)
Mate (Yerba Mate) extract
20 mg
Market median: 200.0mg (107 products)
BioPerine Complex
3 mg

Other Ingredients

Gelatin Water, Purified Glycerin Beeswax Sunflower Lecithin Rice Flour Annatto Maltodextrin Titanium Dioxide Turmeric Soybean Oil St. John's Bread Dicalcium Phosphate Silicon Dioxide Sodium Copper Chlorophyllin
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: (Adult) As an addition to your reduced calorie diet and exercise plan, take three (3) Liquid Soft-Gels in the morning and three (3) Liquid Soft-Gels in the afternoon with meals and a full glass (8oz) of water. If caffeine keeps you up at night, do not take this product in the evening since it contains caffeine.

Warnings & Precautions

Usage Warnings: Do not use if safety seal is broken. This product contains an ingredient that may affect blood sugar. This product contains niacin and may cause a temporary warming and tingling sensation.

Check with your doctor before using this product if you are using medication or have any medical conditions, including, but not limited to, heart disease, high blood pressure, an iron deficiency, a liver disorder or develop symptoms of liver trouble (such as abdominal pain, dark urine or jaundice).

It is recommended to limit additional caffeine intake while taking this product.

Do not use if you may become pregnant, are pregnant or nursing.

Do not exceed recommended daily intake.

Not intended for use by persons under 18. Keep out of reach of children.

Warning: (State of California Prop 65) This product contains a chemical known to the State of California to cause birth defects or other reproductive harm.

If caffeine keeps you up at night, do not take this product in the evening since it contains caffeine.

Contains: Fish (anchovy, sardine), Soy

Formulation Notes

System-Six is a specialized formula that delivers six support systems to assist with your weight loss goals.

One: Thermogenesis - A combination of Green and White Tea extracts supply powerful nutrients to enhance thermogenesis (heat production) and help burn calories. Two: Energy - Natural caffeine plus the botanicals Yerba Mate, Guarana and Spirulina help you feel energized. Three: Mood - L - Theanine is included in this formula to support mood. Four: Metabolism - A combination of B vitamins help convert food into energy and assist in the breakdowns of carbs, fats and proteins. Five: Carbohydrate Support - Chromium supports the breakdown to carbohydrates into glucose and helps to maintain healthy blood sugar levels already within a normal range. Six: Antioxidants - Vitamins C and E plus other nutrients with antioxidant activity help to protect cell health and offer nutritional support for the body.

When combined with a reduced calorie diet and exercise plan, System-Six delivers powerful weight loss support to help you meet your goals.

What makes us different: Liquid Soft-Gels - The nutrients in these easy-to-swallow Liquid Soft-Gels are released fast. Other forms of delivery can contain binders and fillers that may cause stomach upset and offer no nutritional value. Advanced Liquid Soft-Gels provide an optimum delivery system.

Quality Assurance - Irwin Naturals is committed to providing the highest quality products for your health. We employ compliance testing to ensure purity and potency.

Patented BioPerine - Our special BioPerine Complex enhances the bioavailability, absorption and potency of many nutrients.

Powerful Weight Loss Support Metabolism Boosters & Carb Metabolizer Complete Six-In-One Formula for Enhanced Metabolism, plus Mood & Energy Support

No preservatives added.

Additional Information

Pass Quality Tested Guaranteed

Global Responsibility - Over the years we have donated to organizations that support the environment and the health of our children.

Store in a cool, dry place.

Diet & Exercise Plan available online at: www.IrwinNaturals.com/deplan 100+ Highly Specialized Products: www.IrwinNaturals.com

Questions: Contact Consumer Affairs 1-800-297-3273 Weekdays 8:00 AM to 5:00 PM (PST) Questions@IrwinNaturals.com Full disclosure ingredient panel

Metadata

Product Details

UPC / SKU7 10363 59875 4
DSLD Entry Date2023-07-18
Product TypeOther Combinations
FormSoftgel Capsule
BrandIrwin Naturals
DSLD ID292134
Data Updated2026-04-11
Research

Research Evidence

2
Research Sources
34
Avg Quality
1
Rct
D Effect of pantothenic acid and ascorbic acid supplementation on human skin wound healing process. A double-blind, prospective and randomized trial
Rct European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes 1995 PubMed
D Pantothenic Acid
View all evidence for Pantothenic Acid →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.