System-Six

product on market Softgel Capsule Irwin Naturals 🟢 Safety: 100/100
Brand: Irwin Naturals
🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 50% of ingredients have research evidence
A Label Compliance Grade

Product Label

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Label Data

3 Liquid Softgel(s) Serving Size
20 Servings
Other Combinations Product Type
50% Evidence Coverage

Supplement Facts — Evidence Check

Calories
25 Calorie(s)
Total Fat
1.5 Gram(s) (2% DV)
Cholesterol
5 mg (2% DV)
Total Carbohydrates
2 Gram(s) (1% DV)
Protein
2 Gram(s)
Vitamin C
8 mg (9% DV)
4.5 mg (30% DV)
✅ Within RDA (0.3× RDA of 15 mg) 📚 177 studies (Tier A: 3, B: 90)
RDA 15mg This product: 4.5mg UL 1000mg
0.5 mg (42% DV)
✅ Within RDA (0.4× RDA of 1.2 mg) 📚 76 studies (Tier A: 0, B: 33)
RDA 1.2mg This product: 0.5mg
0.5 mg (38% DV)
✅ Within RDA (0.4× RDA of 1.3 mg) 📚 12 studies (Tier A: 0, B: 1)
RDA 1.3mg This product: 0.5mg
7 mg (44% DV)
✅ Within RDA (0.5× RDA of 14 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 7mg UL 35mg
7 mcg (292% DV)
✅ 2.9× RDA — within safe limits 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 0.007mg
15 mg (300% DV)
✅ 3.0× RDA — within safe limits 📚 1 studies — no high-quality reviews
RDA 5mg This product: 15mg
20 mg (3% DV)
📊 Market median: 125.0mg (294 products) 📚 36 studies (Tier A: 1, B: 7)
RDA 550mg This product: 20mg UL 3500mg
17 mcg (31% DV)
✅ Within RDA (0.3× RDA of 0.055 mg) 📚 172 studies (Tier A: 0, B: 67)
RDA 0.055mg This product: 0.017mg UL 0.4mg
100 mcg (286% DV)
✅ 2.9× RDA — within safe limits 📚 197 studies (Tier A: 1, B: 55)
RDA 0.035mg This product: 0.1mg
1800 mg
📊 Market median: 750.0mg (447 products) 📚 388 studies (Tier A: 18, B: 204)
This product: 1800mg UL 3000mg
335 mg
📊 Market median: 600.0mg (321 products) 📚 5 studies — no high-quality reviews
This product: 335mg
White Tea Leaf Extract
300 mg
150 mg
📊 Market median: 260.0mg (249 products) 📚 156 studies (Tier A: 4, B: 61)
This product: 150mg
100 mg
📊 Market median: 650.0mg (87 products) 📚 1 studies — no high-quality reviews
This product: 100mg
80 mg
📊 Market median: 500.0mg (861 products) 📚 60 studies (Tier A: 4, B: 13)
This product: 80mg
50 mg
📊 Market median: 200.0mg (358 products) 📚 9 studies (Tier A: 0, B: 2)
This product: 50mg
40 mg
📊 Market median: 500.0mg (223 products) 📚 22 studies (Tier A: 0, B: 1)
This product: 40mg
Cayenne, Powder
20 mg
20 mg
📊 Market median: 250.0mg (337 products) 📚 125 studies (Tier A: 1, B: 41)
This product: 20mg
20 mg
📊 Market median: 495.0mg (70 products)
Median 495.0mg This product: 20mg
20 mg
📊 Market median: 550.0mg (217 products) 📚 29 studies (Tier A: 0, B: 5)
This product: 20mg
Mate (Yerba Mate) extract
20 mg
20 mg
📊 Market median: 200.0mg (107 products)
Median 200.0mg This product: 20mg
BioPerine Complex
3 mg

Other Ingredients

Gelatin Water, Purified Glycerin Beeswax Sunflower Lecithin Rice Flour Annatto Maltodextrin Titanium Dioxide Turmeric Soybean Oil St. John's Bread Dicalcium Phosphate Silicon Dioxide Sodium Copper Chlorophyllin

Label Claims — Verification

❓ Nutrient
❓ All Other
❓ Structure/Function
All Other (96% of products) Structure/Function (80% of products) Nutrient (60% of products) Approved Health (1% of products)

Target Groups

Adult (18 - 50 Years) Women (not pregnant or lactating)

Product Information

📋 Directions for Use

Directions: (Adult) As an addition to your reduced calorie diet and exercise plan, take three (3) Liquid Soft-Gels in the morning and three (3) Liquid Soft-Gels in the afternoon with meals and a full glass (8oz) of water. If caffeine keeps you up at night, do not take this product in the evening since it contains caffeine.

⚠️ Warnings & Precautions

Usage Warnings: Do not use if safety seal is broken. This product contains an ingredient that may affect blood sugar. This product contains niacin and may cause a temporary warming and tingling sensation.

Check with your doctor before using this product if you are using medication or have any medical conditions, including, but not limited to, heart disease, high blood pressure, an iron deficiency, a liver disorder or develop symptoms of liver trouble (such as abdominal pain, dark urine or jaundice).

It is recommended to limit additional caffeine intake while taking this product.

Do not use if you may become pregnant, are pregnant or nursing.

Do not exceed recommended daily intake.

Not intended for use by persons under 18. Keep out of reach of children.

Warning: (State of California Prop 65) This product contains a chemical known to the State of California to cause birth defects or other reproductive harm.

If caffeine keeps you up at night, do not take this product in the evening since it contains caffeine.

Contains: Fish (anchovy, sardine), Soy

🧪 Formulation Notes

System-Six is a specialized formula that delivers six support systems to assist with your weight loss goals.

One: Thermogenesis - A combination of Green and White Tea extracts supply powerful nutrients to enhance thermogenesis (heat production) and help burn calories. Two: Energy - Natural caffeine plus the botanicals Yerba Mate, Guarana and Spirulina help you feel energized. Three: Mood - L - Theanine is included in this formula to support mood. Four: Metabolism - A combination of B vitamins help convert food into energy and assist in the breakdowns of carbs, fats and proteins. Five: Carbohydrate Support - Chromium supports the breakdown to carbohydrates into glucose and helps to maintain healthy blood sugar levels already within a normal range. Six: Antioxidants - Vitamins C and E plus other nutrients with antioxidant activity help to protect cell health and offer nutritional support for the body.

When combined with a reduced calorie diet and exercise plan, System-Six delivers powerful weight loss support to help you meet your goals.

What makes us different: Liquid Soft-Gels - The nutrients in these easy-to-swallow Liquid Soft-Gels are released fast. Other forms of delivery can contain binders and fillers that may cause stomach upset and offer no nutritional value. Advanced Liquid Soft-Gels provide an optimum delivery system.

Quality Assurance - Irwin Naturals is committed to providing the highest quality products for your health. We employ compliance testing to ensure purity and potency.

Patented BioPerine - Our special BioPerine Complex enhances the bioavailability, absorption and potency of many nutrients.

Powerful Weight Loss Support Metabolism Boosters & Carb Metabolizer Complete Six-In-One Formula for Enhanced Metabolism, plus Mood & Energy Support

No preservatives added.

Additional Information

Pass Quality Tested Guaranteed

Global Responsibility - Over the years we have donated to organizations that support the environment and the health of our children.

Store in a cool, dry place.

Diet & Exercise Plan available online at: www.IrwinNaturals.com/deplan 100+ Highly Specialized Products: www.IrwinNaturals.com

Questions: Contact Consumer Affairs 1-800-297-3273 Weekdays 8:00 AM to 5:00 PM (PST) Questions@IrwinNaturals.com Full disclosure ingredient panel

Product Details

UPC / SKU 7 10363 59875 4
DSLD Entry Date 2023-07-18
Product Type Other Combinations
Form Softgel Capsule
Brand Irwin Naturals
DSLD ID 292134
Data Updated 2026-04-11

Research Evidence

2 Research Sources
34 Avg Quality Score
1 Rct
D Effect of pantothenic acid and ascorbic acid supplementation on human skin wound healing process. A double-blind, prospective and randomized trial
Rct European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes 1995
PubMed
D Pantothenic Acid
View all evidence for Pantothenic Acid →

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