Is 50 mcg of Vitamin D safe?

This is 3.3× the recommended daily intake of 0.015 mg. While above typical doses, it may still be within safe limits (UL: 0.1 mg).

Is 20.1 mg of Vitamin E safe?

Yes — this is 1.3× the recommended daily intake of 15 mg, which is within safe limits.

Is 10 mg of Thiamine safe?

This is 8.3× the recommended daily intake of 1.2 mg. While above typical doses, it may still be within safe limits (UL: None mg).

Daily One by Puritan's Pride — Ingredients, Evidence & Safety

🟢 99/100

This product looks safe

Folate: 666mg is 666.0× the Tolerable Upper Intake Level (1.0mg)
71% of ingredients have research evidence

C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

The profile includes essential vitamins A, C, D, E, and thiamine, which are supported by strong evidence for maintaining immune function and cellular health. These nutrients play critical roles in metabolic processes and antioxidant defense. The formulation maintains a high safety score, indicating a low risk of adverse effects.

AI-generated summary based on research evidence. Not medical advice.

Product Label

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Safety Alerts

⚠️ Folate: 666mg is 666.0× the Tolerable Upper Intake Level (1.0mg)

Label Data

1 Caplet(s) Serving Size

60 Servings

Other Combinations Product Type

71% Evidence Coverage

Supplement Facts — Evidence Check

Vitamin A

1500 mcg (167% DV)

Vitamin C

120 mg (133% DV)

Vitamin D

50 mcg (250% DV)

📊 3.3× RDA — above typical dose (UL: 0.1 mg) 📚 608 studies (Tier A: 16, B: 251)

RDA 0.015mg This product: 0.05mg UL 0.1mg

Vitamin E

20.1 mg (134% DV)

✅ 1.3× RDA — within safe limits 📚 179 studies (Tier A: 3, B: 90)

RDA 15mg This product: 20.1mg UL 1000mg

Thiamine

10 mg (833% DV)

📊 8.3× RDA — above typical dose 📚 76 studies (Tier A: 0, B: 33)

RDA 1.2mg This product: 10mg

Riboflavin

10 mg (769% DV)

📊 7.7× RDA — above typical dose 📚 13 studies (Tier A: 0, B: 1)

RDA 1.3mg This product: 10mg

Niacin

25 mg (156% DV)

✅ 1.8× RDA — within safe limits 📚 196 studies (Tier A: 5, B: 63)

RDA 14mg This product: 25mg UL 35mg

Vitamin B6

10 mg (588% DV)

📊 7.7× RDA — above typical dose (UL: 100 mg) 📚 114 studies (Tier A: 3, B: 35)

RDA 1.3mg This product: 10mg UL 100mg

Folate

666 mcg DFE (167% DV)

⚠️ Exceeds Tolerable Upper Intake Level by 666.0× (UL: 1.0 mg) 📚 226 studies (Tier A: 10, B: 105)

RDA 0.4mg This product: 666mg UL 1.0mg

Vitamin B12

250 mcg (10417% DV)

📊 104.2× RDA — above typical dose 📚 139 studies (Tier A: 1, B: 44)

RDA 0.0024mg This product: 0.25mg

Biotin

300 mcg (1000% DV)

📊 10.0× RDA — above typical dose 📚 27 studies (Tier A: 0, B: 11)

RDA 0.03mg This product: 0.3mg

Pantothenic Acid

10 mg (200% DV)

✅ 2.0× RDA — within safe limits 📚 2 studies — no high-quality reviews

RDA 5mg This product: 10mg

Calcium

50 mg (4% DV)

Iodine

150 mcg (100% DV)

✅ Within RDA (1.0× RDA of 0.15 mg) 📚 245 studies (Tier A: 4, B: 133)

RDA 0.15mg This product: 0.15mg UL 1.1mg

Magnesium

50 mg (12% DV)

✅ Within RDA (0.1× RDA of 420 mg) 📚 316 studies (Tier A: 8, B: 159)

RDA 420mg This product: 50mg UL 350mg

Zinc

15 mg (136% DV)

✅ 1.4× RDA — within safe limits 📚 263 studies (Tier A: 6, B: 134)

RDA 11mg This product: 15mg UL 40mg

Selenium

200 mcg (364% DV)

📊 3.6× RDA — above typical dose (UL: 0.4 mg) 📚 173 studies (Tier A: 0, B: 67)

RDA 0.055mg This product: 0.2mg UL 0.4mg

Copper

2 mg (222% DV)

✅ 2.2× RDA — within safe limits 📚 37 studies (Tier A: 0, B: 11)

RDA 0.9mg This product: 2mg UL 10mg

Manganese

2 mg (87% DV)

✅ Within RDA (0.9× RDA of 2.3 mg) 📚 9 studies — no high-quality reviews

RDA 2.3mg This product: 2mg UL 11mg

Chromium

200 mcg (571% DV)

📊 5.7× RDA — above typical dose 📚 199 studies (Tier A: 1, B: 55)

RDA 0.035mg This product: 0.2mg

Molybdenum

15 mcg (33% DV)

✅ Within RDA (0.3× RDA of 0.045 mg) 📚 3 studies — no high-quality reviews

RDA 0.045mg This product: 0.015mg UL 2mg

Potassium

1 mg (1% DV)

Inositol

10 mg

📊 Market median: 550.0mg (217 products) 📚 29 studies (Tier A: 0, B: 5)

This product: 10mg

Choline Bitartrate

10 mg

📊 Market median: 125.0mg (294 products) 📚 38 studies (Tier A: 1, B: 7)

RDA 550mg This product: 10mg UL 3500mg

Other Ingredients

Cellulose Citrus Bioflavonoids Gelatin Kelp natural Palm leaf glaze Rose Hips Rutin Silica Titanium Dioxide Magnesium Stearate Stearic Acid

Label Claims — Verification

❓ Nutrient

❓ All Other

All Other (99% of products) Structure/Function (76% of products) Nutrient (58% of products)

Target Groups

Adult (18 - 50 Years) Women (not pregnant or lactating) Gluten Free Dairy Free Sugar Free

Product Information

📋 Directions for Use

Directions: For adults, take one (1) caplet daily, preferably with a meal.

⚠️ Warnings & Precautions

Contains bioengineered food ingredients.

Warning: Not intended for use by pregnant or nursing women. If you are taking any medications, planning any medical or surgical procedure, have any medical condition, or are planning to undergo any clinical lab testing, consult your doctor before use. Some supplements may interact with certain medications and/or interfere with certain lab tests.

Discontinue use and consult your doctor if any adverse reactions occur.

Keep out of reach of children.

Do not use if seal under cap is broken or missing.

🧪 Formulation Notes

No artificial flavor, no sugar, no milk, no lactose, no gluten, no wheat, no yeast.

Iron Free

Timed Release Long Acting

Additional Information

Store at room temperature.

To reorder item # 19477 www.puritan.com 1-800-645-1030

QA Quality Assured

Product Details

UPC / SKU 0 25077 19477 3

DSLD Entry Date 2023-05-24

Product Type Other Combinations

Form Other (e.g. tea bag)

Brand Puritan's Pride

DSLD ID 286019

Data Updated 2026-04-11

Research Evidence

337 Research Sources

54 Avg Quality Score

161 Meta Analysis

68 Systematic Review

51 Rct

48 Clinical Trial

2 Other

2 Regulatory Source

1 Narrative Review

1 Cochrane Review

1 Guideline

1 Openfda Safety

A Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age

Meta Analysis The Cochrane database of systematic reviews 2017

PubMed DOI Cochrane

A Vitamin A supplementation for the prevention of morbidity and mortality in infants six months of age or less

Meta Analysis The Cochrane database of systematic reviews 2011

PubMed DOI Cochrane

A Vitamin A supplementation for reducing the risk of mother-to-child transmission of HIV infection

Meta Analysis The Cochrane database of systematic reviews 2011

PubMed DOI Cochrane

A Vitamin A supplements for preventing mortality, illness, and blindness in children aged under 5: systematic review and meta-analysis

Meta Analysis BMJ (Clinical research ed.) 2011

PubMed DOI

A Fortification of staple foods with vitamin A for vitamin A deficiency

Systematic Review The Cochrane database of systematic reviews 2019

PubMed DOI Cochrane

A Vitamin A supplementation for the prevention of morbidity and mortality in infants one to six months of age

Narrative Review The Cochrane database of systematic reviews 2016

PubMed DOI Cochrane

A Vitamin A and fish oils for preventing the progression of retinitis pigmentosa

Meta Analysis The Cochrane database of systematic reviews 2020

PubMed DOI

A Exercise training-induced changes in exerkine concentrations may be relevant to the metabolic control of type 2 diabetes mellitus patients: A systematic review and meta-analysis of randomized controlled trials

Meta Analysis Journal of sport and health science 2023

PubMed DOI

A Food fortification with multiple micronutrients: impact on health outcomes in general population

Meta Analysis The Cochrane database of systematic reviews 2019

PubMed DOI

A Oral vitamin A supplements to prevent acute upper respiratory tract infections in children up to seven years of age

Meta Analysis The Cochrane database of systematic reviews 2024

PubMed DOI

View all evidence for Vitamin A →