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OsteoPrime Plus Calcium & Magnesium

product on market Tablet or Pill Nature's Way Safety: 97/100
97/100

This product looks safe

  • Niacin: 50mg is 1.4× the Tolerable Upper Intake Level (35mg)
  • Folate: 800mg is 800.0× the Tolerable Upper Intake Level (1.0mg)
  • 60% of ingredients have research evidence
D Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

Vitamin D3 and K1 have strong evidence for supporting bone health and calcium regulation. Vitamin C contributes to collagen synthesis and antioxidant function. Overall evidence coverage for this specific ingredient profile is limited at 0.6%, though the formulation maintains a high safety score.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Niacin: 50mg is 1.4× the Tolerable Upper Intake Level (35mg)

Folate: 800mg is 800.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for OsteoPrime Plus Calcium & Magnesium
Open Full PDF View on NIH DSLD →
Details

Label Data

4 Tablet(s)
Serving Size
30
Servings
Other Combinations
Product Type
60%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Calories
10 Calorie(s)
Total Carbohydrates
2 Gram(s) (1% DV)
Vitamin C
120 mg (133% DV)
20 mcg (100% DV)
1.3× RDA — within safe limits 608 studies (A:16, B:251)
300 mcg (250% DV)
2.5× RDA — within safe limits 275 studies (A:9, B:175)
20 mg (1667% DV)
16.7× RDA — above typical dose 76 studies (A:0, B:33)
20 mg (1538% DV)
15.4× RDA — above typical dose 13 studies (A:0, B:1)
50 mg (313% DV)
Exceeds UL by 1.4× (UL: 35 mg) 196 studies (A:5, B:63)
20 mg (1176% DV)
15.4× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
800 mcg DFE (200% DV)
Exceeds UL by 800.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
50 mcg (2083% DV)
20.8× RDA — above typical dose 139 studies (A:1, B:44)
20 mg (400% DV)
4.0× RDA — above typical dose 2 studies — no high-quality reviews
Calcium
800 mg (62% DV)
128 mg (10% DV)
Within RDA (0.2× RDA) 13 studies (A:0, B:3)
300 mg (71% DV)
Within RDA (0.7× RDA) 316 studies (A:8, B:159)
20 mg (182% DV)
1.8× RDA — within safe limits 263 studies (A:6, B:134)
100 mcg (182% DV)
1.8× RDA — within safe limits 173 studies (A:0, B:67)
2 mg (222% DV)
2.2× RDA — within safe limits 37 studies (A:0, B:11)
7 mg (304% DV)
3.0× RDA — within safe limits 9 studies — no high-quality reviews
50 mcg (111% DV)
1.1× RDA — within safe limits 3 studies — no high-quality reviews
Sodium
5 mg (1% DV)
Market median: 496.0mg (192 products) 20 studies — no high-quality reviews
5 mg
Market median: 108.0mg (8 products) 9 studies (A:0, B:4)
3 mg
Market median: 3.0mg (58 products) 3 studies — no high-quality reviews
45 mcg
Within RDA (0.4× RDA) 275 studies (A:9, B:175)

Other Ingredients

Cellulose Sodium Croscarmellose Stearic Acid Magnesium Stearate Hypromellose Glycerin
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Recommendation: Adults take 4 tablets daily with food. Do not exceed recommended dose.

Warnings & Precautions

Keep out of reach of children.

Safety sealed with inner seal. Do not use if seal is broken or missing.

Warning: Do not take if you are pregnant or nursing.

If you have a blood clotting issue, or if you are taking any medications, consult a healthcare professional before use.

Formulation Notes

No wheat, dairy, gelatin, or artificial colors.

Bottled and tested in the USA

Vegetarian Gelatin Free

Vegetarian Gelatin Free

OsteoPrime Plus With Vitamin D3

To promote calcium absorption Supports bone health and muscle function

Additional Information

Keep tightly closed. Store at room temperature. Avoid excessive heat and direct sunlight.

Questions? 1-800-962-8873/ naturesway.com Bottle made from 50% Post-consumer recycled plastic

Vegetarian Gelatin Free

Physician Formulated by Alan Gaby, M.D.

Metadata

Product Details

UPC / SKU7 63948 07712 0
DSLD Entry Date2025-09-25
Product TypeOther Combinations
FormTablet or Pill
BrandNature's Way
DSLD ID332963
Data Updated2026-04-11
Research

Research Evidence

849
Research Sources
56
Avg Quality
450
Meta Analysis
152
Rct
137
Systematic Review
73
Clinical Trial
11
Regulatory Source
7
Other
7
Guideline
3
Openfda Safety
2
Cochrane Review
2
Observational
A Phosphate binders for preventing and treating chronic kidney disease-mineral and bone disorder (CKD-MBD)
Meta Analysis The Cochrane database of systematic reviews 2018 PubMed DOI
A Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes
Meta Analysis The Cochrane database of systematic reviews 2024 PubMed DOI
A Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life
Meta Analysis The Cochrane database of systematic reviews 2018 PubMed DOI
A Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems
Meta Analysis The Cochrane database of systematic reviews 2025 PubMed DOI
A Dietary calcium supplementation for preventing colorectal cancer and adenomatous polyps
Systematic Review The Cochrane database of systematic reviews 2008 PubMed DOI
A Calcium and vitamin D for increasing bone mineral density in premenopausal women
Systematic Review The Cochrane database of systematic reviews 2023 PubMed DOI
A Dietary sodium, sodium-to-potassium ratio, and risk of stroke: A systematic review and nonlinear dose-response meta-analysis
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2019 PubMed DOI
A The association between circulating magnesium and clinically relevant outcomes in patients with chronic kidney disease: A systematic review and meta-analysis
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2021 PubMed DOI
A Calcium channel blockers versus other classes of drugs for hypertension
Systematic Review The Cochrane database of systematic reviews 2021 PubMed DOI
View all evidence for Electrolytes →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.