Co-Defense
99/100
This product looks safe
- Niacin: 40mg is 1.1× the Tolerable Upper Intake Level (35mg)
- 76% of ingredients have research evidence
C
Label Compliance Grade
Product Label
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Safety Alerts
⚠️ Niacin: 40mg is 1.1× the Tolerable Upper Intake Level (35mg)
Label Data
2 Tablet(s)
Serving Size
100
Servings
Other Combinations
Product Type
76%
Evidence Coverage
Supplement Facts — Evidence Check
400 IU
(100% DV)
✅ Within RDA (0.7× RDA of 0.015 mg)
📚 604 studies (Tier A: 16, B: 251)
10 mcg
(13% DV)
✅ Within RDA (0.1× RDA of 0.12 mg)
📚 273 studies (Tier A: 9, B: 175)
3 mg
(200% DV)
✅ 2.5× RDA — within safe limits
📚 76 studies (Tier A: 0, B: 33)
3.4 mg
(200% DV)
✅ 2.6× RDA — within safe limits
📚 12 studies (Tier A: 0, B: 1)
40 mg
(200% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 1.1× (UL: 35 mg)
📚 193 studies (Tier A: 5, B: 63)
4 mg
(200% DV)
📊 3.1× RDA — above typical dose (UL: 100 mg)
📚 113 studies (Tier A: 3, B: 35)
400 mcg
(100% DV)
✅ Within RDA (1.0× RDA of 0.4 mg)
📚 225 studies (Tier A: 10, B: 105)
25 mcg
(417% DV)
📊 10.4× RDA — above typical dose
📚 138 studies (Tier A: 1, B: 44)
300 mcg
(100% DV)
📊 10.0× RDA — above typical dose
📚 26 studies (Tier A: 0, B: 11)
20 mg
(200% DV)
📊 4.0× RDA — above typical dose
📚 1 studies — no high-quality reviews
Calcium
200 mg
(20% DV)
50 mg
(5% DV)
✅ Within RDA (0.1× RDA of 700 mg)
📚 12 studies (Tier A: 0, B: 3)
150 mcg
(100% DV)
✅ Within RDA (1.0× RDA of 0.15 mg)
📚 243 studies (Tier A: 4, B: 133)
100 mg
(25% DV)
📊 Market median: 4002.0mg (1 products)
📚 20 studies (Tier A: 0, B: 2)
20 mcg
(29% DV)
✅ Within RDA (0.4× RDA of 0.055 mg)
📚 172 studies (Tier A: 0, B: 67)
2 mg
(100% DV)
✅ Within RDA (0.9× RDA of 2.3 mg)
📚 8 studies — no high-quality reviews
150 mcg
(125% DV)
📊 4.3× RDA — above typical dose
📚 197 studies (Tier A: 1, B: 55)
75 mcg
(100% DV)
✅ 1.7× RDA — within safe limits
📚 2 studies — no high-quality reviews
750 mcg
📊 Market median: 3.0mg (58 products)
📚 2 studies — no high-quality reviews
1 mg
📊 Market median: 10.0mg (35 products)
📚 5 studies (Tier A: 0, B: 2)
10 mcg
📊 Market median: 0.5mg (6 products)
📚 1 studies (Tier A: 0, B: 1)
Other Ingredients
Microcrystalline Cellulose
Stearic Acid
Magnesium Stearate
Acacia Gum
Maltodextrin
Water, Purified
Hydroxypropyl Methylcellulose
Glycerin
Label Claims — Verification
❓
Nutrient
❓
All Other
❓
Structure/Function
All Other (99% of products)
Structure/Function (85% of products)
Nutrient (70% of products)
Approved Health (4% of products)
Target Groups
Adult (18 - 50 Years)
Product Information
📋 Directions for Use
Recommended intake: Two tablets daily with meals.
2-per-day mini-tablets
⚠️ Warnings & Precautions
Keep out of reach of children.
Tamper resistant package. Do not use if outer seal is broken.
Contains: Soy
🧪 Formulation Notes
Co-Defense formula is a multivitamin specifically designed for people who take macular degeneration supplements that are based upon the National Eye Institute's age related eye disease study. To prevent taking unneeded ingredients already present in these eye supplements, Co-Defense contains no vitamin A, C, E, zinc or copper.
Compared with other popular daily multivitamins, co-defense contains more of the water-soluble B-vitamins and lycopene that are known to be of grater importance as we age.
Made in the USA
AREDS complementary multivitamin Now with 1 mg lycopene
Additional Information
Store at room temperature.
Product Details
Research Evidence
872
Research Sources
53
Avg Quality Score
309
Meta Analysis
309
Clinical Trial
111
Rct
71
Systematic Review
55
Guideline
4
Cochrane Review
4
Regulatory Source
2
Other
2
Narrative Review
2
Observational
1
Openfda Safety
A
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A
Vitamin D and vitamin D analogues for preventing fractures in post-menopausal women and older men
A
The effect of vitamin D supplementation on depressive symptoms in adults: A systematic review and meta-analysis of randomized controlled trials
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