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Co-Defense

product on market Tablet or Pill VisiVite Safety: 97/100
97/100

This product looks safe

  • Niacin: 40mg is 1.1× the Tolerable Upper Intake Level (35mg)
  • Folate: 665mg is 665.0× the Tolerable Upper Intake Level (1.0mg)
  • 76% of ingredients have research evidence
D Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

This profile includes B vitamins and vitamins D and K, which are supported by strong evidence for metabolic function and bone health. However, the overall evidence coverage for this specific formulation is limited. The ingredient profile maintains a high safety score.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Niacin: 40mg is 1.1× the Tolerable Upper Intake Level (35mg)

Folate: 665mg is 665.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for Co-Defense
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
100
Servings
Other Combinations
Product Type
76%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

10 mcg (50% DV)
Within RDA (0.7× RDA) 608 studies (A:16, B:251)
10 mcg (8% DV)
Within RDA (0.1× RDA) 275 studies (A:9, B:175)
3 mg (250% DV)
2.5× RDA — within safe limits 76 studies (A:0, B:33)
3.4 mg (262% DV)
2.6× RDA — within safe limits 13 studies (A:0, B:1)
40 mg (250% DV)
Exceeds UL by 1.1× (UL: 35 mg) 196 studies (A:5, B:63)
4 mg (235% DV)
3.1× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
665 mcg DFE (166% DV)
Exceeds UL by 665.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
25 mcg (1042% DV)
10.4× RDA — above typical dose 139 studies (A:1, B:44)
300 mcg (1000% DV)
10.0× RDA — above typical dose 27 studies (A:0, B:11)
20 mg (400% DV)
4.0× RDA — above typical dose 2 studies — no high-quality reviews
Calcium
200 mg (15% DV)
50 mg (4% DV)
Within RDA (0.1× RDA) 13 studies (A:0, B:3)
150 mcg (100% DV)
Within RDA (1.0× RDA) 245 studies (A:4, B:133)
100 mg (24% DV)
Within RDA (0.2× RDA) 316 studies (A:8, B:159)
20 mcg (36% DV)
Within RDA (0.4× RDA) 173 studies (A:0, B:67)
2 mg (87% DV)
Within RDA (0.9× RDA) 9 studies — no high-quality reviews
150 mcg (429% DV)
4.3× RDA — above typical dose 199 studies (A:1, B:55)
75 mcg (167% DV)
1.7× RDA — within safe limits 3 studies — no high-quality reviews
0.75 mg
Market median: 3.0mg (58 products) 3 studies — no high-quality reviews
1 mg
Market median: 10.0mg (35 products) 6 studies (A:0, B:2)
10 mcg
Market median: 0.5mg (6 products) 1 studies (A:0, B:1)

Other Ingredients

Microcrystalline Cellulose Stearic Acid Croscarmellose Sodium Vegetable Stearate Water, Purified Hydroxypropyl Methylcellulose Glycerin
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Recommended intake: One tablet daily with meals.

1-per-day tablets

Warnings & Precautions

Keep out reach of children.

Tamper resistant package. Do not use if outer seal is broken.

Formulation Notes

Co-defense formula is a multivitamin specifically designed for people who take macular degeneration supplements that are based upon the National Eye Institution's age related eye disease study.

To prevent taking unneeded ingredients already present in these eyes supplements, Co-Defense contains no vitamin A, C, E, zinc or copper.

Compared with other popular daily multivitamins, Co-Defense contains more of the water-soluble B-vitamins and lycopene that are known to be of greater importance as we age.

Made in USA

AREDS complementary multivitamin Now with 1 mg lycopene

Additional Information

Store at room temperature

Metadata

Product Details

UPC / SKU8 99205 00003 4
DSLD Entry Date2023-05-24
Product TypeOther Combinations
FormTablet or Pill
BrandVisiVite
DSLD ID292318
Data Updated2026-04-11
Research

Research Evidence

872
Research Sources
53
Avg Quality
309
Meta Analysis
309
Clinical Trial
111
Rct
71
Systematic Review
55
Guideline
4
Cochrane Review
4
Regulatory Source
2
Other
2
Narrative Review
2
Observational
1
Openfda Safety
A Vitamin D and vitamin D analogues for preventing fractures associated with involutional and post-menopausal osteoporosis
Meta Analysis The Cochrane database of systematic reviews 2009 PubMed DOI
A Vitamin D supplementation for prevention of mortality in adults
Meta Analysis The Cochrane database of systematic reviews 2014 PubMed DOI
A Vitamin D and vitamin D analogues for preventing fractures in post-menopausal women and older men
Meta Analysis The Cochrane database of systematic reviews 2014 PubMed DOI
A Vitamin D supplementation for prevention of cancer in adults
Meta Analysis The Cochrane database of systematic reviews 2014 PubMed DOI
A Interventions for preventing falls in older people in care facilities and hospitals
Meta Analysis The Cochrane database of systematic reviews 2018 PubMed DOI
A Drugs for preventing lung cancer in healthy people
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
A Vitamin D supplementation for prevention of mortality in adults
Meta Analysis The Cochrane database of systematic reviews 2011 PubMed DOI
A High prevalence of vitamin D deficiency in Asia: A systematic review and meta-analysis
Meta Analysis Critical reviews in food science and nutrition 2023 PubMed DOI
A The effect of vitamin D supplementation on depressive symptoms in adults: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Critical reviews in food science and nutrition 2023 PubMed DOI
A Interventions for preventing falls in older people living in the community
Meta Analysis The Cochrane database of systematic reviews 2009 PubMed DOI
View all evidence for Vitamin D →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.