Triple Probiotic by Nature Made — Ingredients, Evidence & Safety

🟢 100/100

This product looks safe

No ingredients exceed tolerable upper intake levels
70% of ingredients have research evidence

A Label Compliance Grade

Product Label

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Label Data

1 Caplet(s) Serving Size

Other Combinations Product Type

70% Evidence Coverage

Supplement Facts — Evidence Check

Vitamin A

3390 IU (68% DV)

Vitamin C

55 mg (92% DV)

Vitamin D3

430 IU (108% DV)

✅ Within RDA (0.7× RDA of 0.015 mg) 📚 604 studies (Tier A: 16, B: 251)

RDA 0.015mg This product: 0.010750000000000001mg UL 0.1mg

Vitamin E

27 IU (90% DV)

✅ 1.2× RDA — within safe limits 📚 177 studies (Tier A: 3, B: 90)

RDA 15mg This product: 18.09mg UL 1000mg

Thiamine

1.5 mg (100% DV)

✅ 1.2× RDA — within safe limits 📚 76 studies (Tier A: 0, B: 33)

RDA 1.2mg This product: 1.5mg

Riboflavin

1.6 mg (94% DV)

✅ 1.2× RDA — within safe limits 📚 12 studies (Tier A: 0, B: 1)

RDA 1.3mg This product: 1.6mg

Niacin

20 mg (100% DV)

✅ 1.4× RDA — within safe limits 📚 193 studies (Tier A: 5, B: 63)

RDA 14mg This product: 20mg UL 35mg

Vitamin B6

2 mg (100% DV)

✅ 1.5× RDA — within safe limits 📚 113 studies (Tier A: 3, B: 35)

RDA 1.3mg This product: 2mg UL 100mg

Folic Acid

465 mcg (116% DV)

✅ 1.2× RDA — within safe limits 📚 225 studies (Tier A: 10, B: 105)

RDA 0.4mg This product: 0.465mg UL 1.0mg

Vitamin B12

6.6 mcg (110% DV)

✅ 2.8× RDA — within safe limits 📚 138 studies (Tier A: 1, B: 44)

RDA 0.0024mg This product: 0.0066mg

Biotin

133 mcg (44% DV)

📊 4.4× RDA — above typical dose 📚 26 studies (Tier A: 0, B: 11)

RDA 0.03mg This product: 0.133mg

Pantothenic Acid

10 mg (100% DV)

✅ 2.0× RDA — within safe limits 📚 1 studies — no high-quality reviews

RDA 5mg This product: 10mg

Calcium

80 mg (8% DV)

Iron

18 mg (100% DV)

Phosphorus

30 mg (3% DV)

📊 Market median: 99.0mg (503 products) 📚 12 studies (Tier A: 0, B: 3)

RDA 700mg This product: 30mg UL 4000mg

Iodine

100 mcg (67% DV)

✅ Within RDA (0.7× RDA of 0.15 mg) 📚 243 studies (Tier A: 4, B: 133)

RDA 0.15mg This product: 0.1mg UL 1.1mg

Magnesium

42 mg (11% DV)

📊 Market median: 4002.0mg (1 products) 📚 20 studies (Tier A: 0, B: 2)

This product: 42mg

Zinc

15 mg (100% DV)

✅ 1.4× RDA — within safe limits 📚 258 studies (Tier A: 6, B: 134)

RDA 11mg This product: 15mg UL 40mg

Selenium

21 mcg (30% DV)

✅ Within RDA (0.4× RDA of 0.055 mg) 📚 172 studies (Tier A: 0, B: 67)

RDA 0.055mg This product: 0.021mg UL 0.4mg

Manganese

1.2 mg (60% DV)

✅ Within RDA (0.5× RDA of 2.3 mg) 📚 8 studies — no high-quality reviews

RDA 2.3mg This product: 1.2mg UL 11mg

Chromium

21 mcg (18% DV)

✅ Within RDA (0.6× RDA of 0.035 mg) 📚 197 studies (Tier A: 1, B: 55)

RDA 0.035mg This product: 0.021mg

Molybdenum

21 mcg (28% DV)

✅ Within RDA (0.5× RDA of 0.045 mg) 📚 2 studies — no high-quality reviews

RDA 0.045mg This product: 0.021mg UL 2mg

Probiotic Blend

29.5 mg

📊 Market median: 80.0mg (20 products) 📚 334 studies (Tier A: 8, B: 183)

This product: 29.5mg

Other Ingredients

Cellulose Gel Tribasic Calcium Phosphate Inulin Magnesium Oxide Calcium Ascorbate Ferrous Sulfate Hydroxypropyl Methylcellulose DL-Alpha-Tocopheryl Acetate Mono & Diglycerides of Fatty Acids Polyvinylpolypyrrolidone Calcium D-Pantothenate Magnesium Stearate Potassium Chloride Cellulose Gum Corn Oil / Medium Chain Triglycerides Sugar Manganese Sulfate Glucose Silicon Dioxide Sodium Selenate Pyridoxine Hydrochloride Fructose Thiamine Mononitrate Riboflavin Red 40 Vitamin A Acetate Folic Acid Dextrin Chromium Chloride Potassium Iodide Biotin Sodium Molybdate Vitamin D3 Cyanocobalamin

Label Claims — Verification

❓ All Other

❓ Structure/Function

All Other (99% of products) Structure/Function (91% of products) Nutrient (14% of products)

Target Groups

Adult (18 - 50 Years)

Product Information

📋 Directions for Use

Suggested Use: Take one caplet daily with a cold or room temperature drink. Do not chew or take with hot drinks. Take 2 hours before or after taking other medication, such as antibiotics. Take with food when possible.

⚠️ Warnings & Precautions

Caution: If you are pregnant or nursing, consult your physician before taking this product.

WARNING: Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6. Keep this product of out reach of children. In case of accidental overdose, call a doctor or poison control center immediately.

Do not use if seal under cap is broken or missing.

May contain traces of milk proteins and phenylalanine.

🧪 Formulation Notes

- No Artificial Flavors - No Preservatives

May contain traces of milk proteins and phenylalanine.

Additional Information

Made in Austria.

ONCE DAILY

Keep bottle tightly closed. Store in a cool dry place. No refrigeration necessary.

SMART RELEASE** TRI-LAYER CAPLET PROBIOTICS MINERALS VITAMINS

Triple Probiotic caplets are made to Nature Made's guaranteed purity and potency standards. ^Valid only for U.S. and Puerto Rico residents.

NEW

The digestive tract, or gut is the body's largest immune system organ, so it is important to promote digestive vitality in order to maintain immune health.* Probiotics promote a healthy balance within the digestive tract so that your immune system stays strong naturally. Nature Made Triple Probiotic also contains several key minerals and vitamins known to support the immune system. Working together, this unique combination of nutrients provides dual levels of support to maintain immune system health.* **Smart release, tri-layer caplet is designed to maximize efficacy: - Ensures delivery of live probiotics to the gut - Probiotics are released in the gut for immune health benefits - Vitamins and minerals are released in the stomach for optimal absorption

^Enter Code for Wellness Rewards Points at www.NatureMade.com DV4X-FYZB

List No: 2660 P33 Cat. A590 1E208 92394101

Naturally helps maintain immune system wellness* Triple probiotic blend with essential vitamins & minerals

Product Details

UPC / SKU 0 31604 02660 8

DSLD Entry Date 2013-03-25

Product Type Other Combinations

Form Other (e.g. tea bag)

Brand Nature Made

DSLD ID 19071

Data Updated 2026-04-11

Research Evidence

691 Research Sources

52 Avg Quality Score

255 Clinical Trial

205 Meta Analysis

123 Rct

81 Systematic Review

18 Cochrane Review

2 Guideline

2 Regulatory Source

1 Other

1 Narrative Review

1 Openfda Safety

A Probiotics for preventing acute upper respiratory tract infections

Systematic Review The Cochrane database of systematic reviews 2022

PubMed DOI Cochrane

A Probiotics for preventing acute upper respiratory tract infections

Meta Analysis The Cochrane database of systematic reviews 2015

PubMed DOI Cochrane

A Probiotics for maintenance of remission in ulcerative colitis

Meta Analysis The Cochrane database of systematic reviews 2020

PubMed DOI

A Probiotics for induction of remission in ulcerative colitis

Meta Analysis The Cochrane database of systematic reviews 2020

PubMed DOI

A Probiotics for preventing acute upper respiratory tract infections

Meta Analysis The Cochrane database of systematic reviews 2011

PubMed DOI Cochrane

A Probiotics for treating eczema

Meta Analysis The Cochrane database of systematic reviews 2018

PubMed DOI Cochrane

A Probiotics for treating acute infectious diarrhoea

Meta Analysis The Cochrane database of systematic reviews 2020

PubMed DOI

A The Gut Microbiome in Depression and Potential Benefit of Prebiotics, Probiotics and Synbiotics: A Systematic Review of Clinical Trials and Observational Studies

Systematic Review International journal of molecular sciences 2022

PubMed DOI

A Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children

Meta Analysis The Cochrane database of systematic reviews 2017

PubMed DOI

A Probiotics to prevent infantile colic

Meta Analysis The Cochrane database of systematic reviews 2019

PubMed DOI

View all evidence for Probiotics →