What the Evidence Says
✨ AI-generated · Qwen 3.6
· methodology
This profile contains essential vitamins including A, C, D3, and B-complex vitamins, which support immune function and cellular metabolism. There is strong research evidence supporting the roles of these nutrients in maintaining general health. The formulation maintains a high safety score with no significant concerns noted.
AI-generated summary based on research evidence. Not medical advice.
Safety Alerts
⚠️ Niacin: 40mg is 1.1× the Tolerable Upper Intake Level (35mg)
⚠️ Folate: 206mg is 206.0× the Tolerable Upper Intake Level (1.0mg)
Label Data
1 Packet(s)
Serving Size
42
Servings
Other Combinations
Product Type
48%
Evidence Coverage
Supplement Facts — Evidence Check
✅ Within RDA (0.1× RDA of 0.015 mg)
📚 608 studies (Tier A: 16, B: 251)
RDA 0.015mg
This product: 0.00125mg
UL 0.1mg
📊 16.7× RDA — above typical dose
📚 76 studies (Tier A: 0, B: 33)
RDA 1.2mg
This product: 20mg
📊 15.4× RDA — above typical dose
📚 13 studies (Tier A: 0, B: 1)
RDA 1.3mg
This product: 20mg
⚠️ Exceeds Tolerable Upper Intake Level by 1.1× (UL: 35 mg)
📚 196 studies (Tier A: 5, B: 63)
RDA 14mg
This product: 40mg
UL 35mg
📊 16.3× RDA — above typical dose (UL: 100 mg)
📚 114 studies (Tier A: 3, B: 35)
RDA 1.3mg
This product: 21.25mg
UL 100mg
⚠️ Exceeds Tolerable Upper Intake Level by 206.0× (UL: 1.0 mg)
📚 226 studies (Tier A: 10, B: 105)
RDA 0.4mg
This product: 206mg
UL 1.0mg
📊 17.3× RDA — above typical dose
📚 139 studies (Tier A: 1, B: 44)
RDA 0.0024mg
This product: 0.0415mg
📊 3.3× RDA — above typical dose
📚 27 studies (Tier A: 0, B: 11)
RDA 0.03mg
This product: 0.1mg
📊 16.0× RDA — above typical dose
📚 2 studies — no high-quality reviews
RDA 5mg
This product: 80mg
📊 Market median: 125.0mg (294 products)
📚 38 studies (Tier A: 1, B: 7)
RDA 550mg
This product: 13mg
UL 3500mg
✅ Within RDA (0.1× RDA of 700 mg)
📚 13 studies (Tier A: 0, B: 3)
RDA 700mg
This product: 47mg
UL 4000mg
✅ Within RDA (0.4× RDA of 420 mg)
📚 316 studies (Tier A: 8, B: 159)
RDA 420mg
This product: 150mg
UL 350mg
✅ Within RDA (0.3× RDA of 11 mg)
📚 263 studies (Tier A: 6, B: 134)
RDA 11mg
This product: 3.75mg
UL 40mg
✅ Within RDA (0.6× RDA of 0.9 mg)
📚 37 studies (Tier A: 0, B: 11)
RDA 0.9mg
This product: 0.5mg
UL 10mg
✅ 2.7× RDA — within safe limits
📚 9 studies — no high-quality reviews
RDA 2.3mg
This product: 6.25mg
UL 11mg
📊 Market median: 3.0mg (58 products)
📚 3 studies — no high-quality reviews
This product: 0.25mg
UL 20mg
Other Ingredients
Gelatin
Glycerin
Water
Carob fruit extract
Caramel color
Gelatin
Water
Cellulose
Stearic Acid
Silicon Dioxide
Magnesium Stearate
Label Claims — Verification
❓
Nutrient
❓
All Other
❓
Structure/Function
All Other (99% of products)
Structure/Function (76% of products)
Nutrient (58% of products)
Target Groups
Adult Female (18 - 50 Years)
Menopause
Seniors/Mature (>50 Years) - Women ONLY
Product Information
📋 Directions for Use
Recommended use: Take the contents of one Natural Changes packet with breakfast, and one with your evening meal. Follow this pattern for 21 days.
⚠️ Warnings & Precautions
Warning: Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6. Keep this product out of the reach of children. In case of accidental overdose, call a doctor or poison control center immediately.
This carton was sealed for your protection. Do not use if seal is missing or damaged.
🧪 Formulation Notes
Nature's Sunshine uses natural source materials that are subject to color variation.
C-X
Provides herbal support for the female reproductive system.
Wild Yam & Chaste Tree
Historically used by women during menopause.
Super GLA
Provides essential Omega 6 fatty acids, which support the female reproductive system.
Skeletal Strength & Nutri-Calm
Helps maintain structural and neurological health.
Menopause & glandular system support
21 day program
Natural Changes support
During menopause, the body requires more of certain nutrients than during other times in life. Natural Changes assists Mother Nature in providing these necessary nutrients. Natural Changes helps replenish the body's supply of vital nutrients used by the female glandular system.
Contents
Natural Changes Packet
2 C-X capsules
1 Wild Yam & Chaste Tree capsule
1 Super GLA capsule
1 Skeletal Strength tablet
1 Nutri-Calm tablet
Additional Information
Please recycle this carton.
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Product Details
DSLD Entry Date
2025-09-25
Product Type
Other Combinations
Form
Other (e.g. tea bag)
Data Updated
2026-04-11
Research Evidence
337
Research Sources
54
Avg Quality Score
161
Meta Analysis
68
Systematic Review
51
Rct
48
Clinical Trial
2
Other
2
Regulatory Source
1
Narrative Review
1
Cochrane Review
1
Guideline
1
Openfda Safety
Meta Analysis
The Cochrane database of systematic reviews
2017
Meta Analysis
The Cochrane database of systematic reviews
2011
Meta Analysis
The Cochrane database of systematic reviews
2011
Meta Analysis
BMJ (Clinical research ed.)
2011
Systematic Review
The Cochrane database of systematic reviews
2019
Narrative Review
The Cochrane database of systematic reviews
2016
Meta Analysis
The Cochrane database of systematic reviews
2020
Meta Analysis
Journal of sport and health science
2023
Meta Analysis
The Cochrane database of systematic reviews
2019
Meta Analysis
The Cochrane database of systematic reviews
2024
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