Is 60 mg of Thiamine safe?

This is 50.0× the recommended daily intake of 1.2 mg. While above typical doses, it may still be within safe limits (UL: None mg).

Is 60 mg of Riboflavin safe?

This is 46.2× the recommended daily intake of 1.3 mg. While above typical doses, it may still be within safe limits (UL: None mg).

Is 125 mg NE of Niacin safe?

No — this amount exceeds the Tolerable Upper Intake Level of 35 mg by 3.6×. The recommended daily intake is 14 mg.

Is 100 mg of Vitamin B6 safe?

This is 76.9× the recommended daily intake of 1.3 mg. While above typical doses, it may still be within safe limits (UL: 100 mg).

Mega-Stress Sustained Release by NaturesPlus — Ingredients, Evidence & Safety

🟢 96/100

This product looks safe

Niacin: 125mg is 3.6× the Tolerable Upper Intake Level (35mg)
Folate: 667mg is 667.0× the Tolerable Upper Intake Level (1.0mg)
76% of ingredients have research evidence

D Label Compliance Grade

What the Evidence Says

This formula contains B vitamins and vitamin C, which are supported by strong evidence for supporting energy metabolism and immune function. These nutrients play essential roles in cellular processes and stress response. The overall safety profile is high, though evidence coverage for this specific combination is limited.

AI-generated summary based on research evidence. Not medical advice.

Product Label

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Safety Alerts

⚠️ Niacin: 125mg is 3.6× the Tolerable Upper Intake Level (35mg)

⚠️ Folate: 667mg is 667.0× the Tolerable Upper Intake Level (1.0mg)

Label Data

1 Tablet(s) Serving Size

90 Servings

Other Combinations Product Type

76% Evidence Coverage

Supplement Facts — Evidence Check

Vitamin C

500 mg (556% DV)

Thiamine

60 mg (5000% DV)

📊 50.0× RDA — above typical dose 📚 76 studies (Tier A: 0, B: 33)

RDA 1.2mg This product: 60mg

Riboflavin

60 mg (4615% DV)

📊 46.2× RDA — above typical dose 📚 13 studies (Tier A: 0, B: 1)

RDA 1.3mg This product: 60mg

Niacin

125 mg NE (781% DV)

⚠️ Exceeds Tolerable Upper Intake Level by 3.6× (UL: 35 mg) 📚 196 studies (Tier A: 5, B: 63)

RDA 14mg This product: 125mg UL 35mg

Vitamin B6

100 mg (5882% DV)

📊 76.9× RDA — above typical dose (UL: 100 mg) 📚 114 studies (Tier A: 3, B: 35)

RDA 1.3mg This product: 100mg UL 100mg

Folate

667 mcg DFE (167% DV)

⚠️ Exceeds Tolerable Upper Intake Level by 667.0× (UL: 1.0 mg) 📚 226 studies (Tier A: 10, B: 105)

RDA 0.4mg This product: 667mg UL 1.0mg

Vitamin B12

250 mcg (10417% DV)

📊 104.2× RDA — above typical dose 📚 139 studies (Tier A: 1, B: 44)

RDA 0.0024mg This product: 0.25mg

Biotin

75 mcg (250% DV)

✅ 2.5× RDA — within safe limits 📚 27 studies (Tier A: 0, B: 11)

RDA 0.03mg This product: 0.075mg

Pantothenic Acid

200 mg (4000% DV)

📊 40.0× RDA — above typical dose 📚 2 studies — no high-quality reviews

RDA 5mg This product: 200mg

Choline

32 mg (6% DV)

✅ Within RDA (0.1× RDA of 550 mg) 📚 38 studies (Tier A: 1, B: 7)

RDA 550mg This product: 32mg UL 3500mg

Calcium

100 mg (8% DV)

Magnesium

50 mg (12% DV)

✅ Within RDA (0.1× RDA of 420 mg) 📚 316 studies (Tier A: 8, B: 159)

RDA 420mg This product: 50mg UL 350mg

Zinc

25 mg (227% DV)

✅ 2.3× RDA — within safe limits 📚 263 studies (Tier A: 6, B: 134)

RDA 11mg This product: 25mg UL 40mg

Inositol

100 mg

📊 Market median: 550.0mg (217 products) 📚 29 studies (Tier A: 0, B: 5)

This product: 100mg

Valerian

50 mg

📊 Market median: 300.0mg (214 products) 📚 25 studies (Tier A: 0, B: 6)

This product: 50mg

Para-Aminobenzoic Acid

30 mg

📊 Market median: 500.0mg (9 products) 📚 7 studies — no high-quality reviews

This product: 30mg

Chamomile

25 mg

📊 Market median: 400.0mg (142 products) 📚 10 studies (Tier A: 0, B: 2)

This product: 25mg

Other Ingredients

Calcium Carbonate Microcrystalline Cellulose Dicalcium Phosphate Stearic Acid Magnesium Oxide Zinc Sulfate Magnesium Stearate Hydroxypropyl Methylcellulose Silica Rose Hip Soy Protein Isolate Rice Pharmaceutical Glaze

Label Claims — Verification

❓ Nutrient

❓ All Other

❓ Structure/Function

All Other (99% of products) Structure/Function (83% of products) Nutrient (54% of products)

Target Groups

Vegetarian Adult (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Directions: one tablet daily.

⚠️ Warnings & Precautions

Keep out of reach of children.

🧪 Formulation Notes

Free from artificial colors and artificial preservatives. Free from the allergens milk, eggs, fish, crustacean shellfish, tree nuts, peanuts and wheat. Gluten free

Vegetarian

In a special base which provides for the gradual release of ingredients over a prolonged period of time. Micro-gel sustained release system

B-complex, vitamin C & herbs

Stress support