Proactive 65+ for Men & Women by Bayer One A Day — Ingredients, Evidence & Safety

🟢 98/100

This product looks safe

Folate: 665mg is 665.0× the Tolerable Upper Intake Level (1.0mg)
70% of ingredients have research evidence

C Label Compliance Grade

Product Label

📄 Open Full PDF View on NIH DSLD →

📸

Have a supplement label? Find it here.

Upload a photo of any supplement label to search our database of 92,312 products.

Safety Alerts

⚠️ Folate: 665mg is 665.0× the Tolerable Upper Intake Level (1.0mg)

Label Data

2 Tablet(s) Serving Size

75 Servings

Multi-Vitamin and Mineral (MVM) Product Type

70% Evidence Coverage

Supplement Facts — Evidence Check

Vitamin A

670 mcg (74% DV)

Vitamin C

90 mg (100% DV)

Vitamin D

30 mcg (150% DV)

✅ 2.0× RDA — within safe limits 📚 604 studies (Tier A: 16, B: 251)

RDA 0.015mg This product: 0.03mg UL 0.1mg

Vitamin K

Thiamine

1.2 mg (100% DV)

✅ Within RDA (1.0× RDA of 1.2 mg) 📚 76 studies (Tier A: 0, B: 33)

RDA 1.2mg This product: 1.2mg

Riboflavin

1.7 mg (131% DV)

✅ 1.3× RDA — within safe limits 📚 12 studies (Tier A: 0, B: 1)

RDA 1.3mg This product: 1.7mg

Niacin

20 mg (125% DV)

✅ 1.4× RDA — within safe limits 📚 193 studies (Tier A: 5, B: 63)

RDA 14mg This product: 20mg UL 35mg

Vitamin B6

2 mg (118% DV)

✅ 1.5× RDA — within safe limits 📚 113 studies (Tier A: 3, B: 35)

RDA 1.3mg This product: 2mg UL 100mg

Folate

665 mcg DFE (166% DV)

⚠️ Exceeds Tolerable Upper Intake Level by 665.0× (UL: 1.0 mg) 📚 225 studies (Tier A: 10, B: 105)

RDA 0.4mg This product: 665mg UL 1.0mg

Vitamin B12

50 mcg (2083% DV)

📊 20.8× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)

RDA 0.0024mg This product: 0.05mg

Biotin

30 mcg (100% DV)

✅ Within RDA (1.0× RDA of 0.03 mg) 📚 26 studies (Tier A: 0, B: 11)

RDA 0.03mg This product: 0.03mg

Pantothenic Acid

10 mg (200% DV)

✅ 2.0× RDA — within safe limits 📚 1 studies — no high-quality reviews

RDA 5mg This product: 10mg

Calcium

500 mg (38% DV)

Iodine

150 mcg (100% DV)

✅ Within RDA (1.0× RDA of 0.15 mg) 📚 243 studies (Tier A: 4, B: 133)

RDA 0.15mg This product: 0.15mg UL 1.1mg

Magnesium

100 mg (24% DV)

📊 Market median: 4002.0mg (1 products) 📚 20 studies (Tier A: 0, B: 2)

This product: 100mg

Zinc

15 mg (136% DV)

✅ 1.4× RDA — within safe limits 📚 258 studies (Tier A: 6, B: 134)

RDA 11mg This product: 15mg UL 40mg

Selenium

55 mcg (100% DV)

✅ Within RDA (1.0× RDA of 0.055 mg) 📚 172 studies (Tier A: 0, B: 67)

RDA 0.055mg This product: 0.055mg UL 0.4mg

Copper

1 mg (111% DV)

✅ 1.1× RDA — within safe limits 📚 36 studies (Tier A: 0, B: 11)

RDA 0.9mg This product: 1mg UL 10mg

Manganese

2 mg (87% DV)

✅ Within RDA (0.9× RDA of 2.3 mg) 📚 8 studies — no high-quality reviews

RDA 2.3mg This product: 2mg UL 11mg

Chromium

24 mcg (69% DV)

✅ Within RDA (0.7× RDA of 0.035 mg) 📚 197 studies (Tier A: 1, B: 55)

RDA 0.035mg This product: 0.024mg

Other Ingredients

Calcium Carbonate Magnesium Oxide Microcrystalline Cellulose Ascorbic Acid Maltodextrin Croscarmellose Sodium Beta Carotene Biotin Cholecalciferol Chromium Chloride Copper Sulfate Cyanocobalamin D-Calcium Pantothenate FD&C Yellow #6 Aluminum Lake Folic Acid Gelatin Hydroxypropyl Methylcellulose Manganese Sulfate Mica Niacinamide Polyethylene Glycol Potassium Iodide Pyridoxine Hydrochloride Riboflavin Silicon Dioxide Sodium Selenite Stearic Acid Thiamine Mononitrate Titanium Dioxide Vitamin A Acetate Zinc Oxide

Label Claims — Verification

❓ Nutrient

❓ All Other

❓ Structure/Function

All Other (99% of products) Structure/Function (76% of products) Nutrient (58% of products)

Target Groups

Seniors/Mature (>50 Years) Dairy Free

Product Information

📋 Directions for Use

Directions: Adults: Two tablets daily, with food.

⚠️ Warnings & Precautions

Not a replacement for heart medications.

For adult use only.

Not for children. Keep out of reach of children

If pregnant, breast-feeding, taking medication, or have any medical condition ask a health professional before use.

Do not exceed recommended intake Do not use this product if printed safety seal bearing "Bayer HealthCare" under cap is torn or missing.

🧪 Formulation Notes

Only complete multivitamin specially formulated for this age: Excellent source of vitamin D - which is harder to get from the sun as you age High potency vitamin B12 - which at this age is easier to absorb from a supplement or fortified food, than what is found naturally in food

Formulated without vitamin K for those who have been instructed by their physician to avoid this vitamin

Formulated to support: Healthy blood pressure with vitamin C, calcium, magnesium and vitamin D Bone health with calcium, magnesium and vitamin D Physical energy with B-vitamins to help convert food to fuel Cell health with antioxidants: vitamins A, C, zinc, manganese, copper and selenium Heart health with vitamins B6, B12 and folic acid

50% smaller than One A Day Women's 50+ Healthy Advantage To help support blood pressure levels already within normal range.

One A Day Proactive 65+ is the only complete multivitamin specially formulated for men and women 65+ with key nutrients important for this age.

Formulated with: Excellent source of vitamin D High potency vitamin B12 And other key nutrients

Free of: Artificial sweeteners and artificial flavors and dairy (milk) and wheat allergens

Easy to swallow mini tablets

Does not contain vitamin K

No artificial sweeteners or flavors

Additional Information

Among the leading brands

Store at room temperature. Avoid excessive heat above 40 degrees C (104 degrees F).

Questions or comments? Please call 1-800-800-4793 (Mon-Fri 9am - 5pm EST)

Product Details

UPC / SKU 0 16500 56164 4

DSLD Entry Date 2022-06-16

Product Type Multi-Vitamin and Mineral (MVM)

Form Tablet or Pill

Brand Bayer One A Day

DSLD ID 269938

Data Updated 2026-04-11

Research Evidence

337 Research Sources

54 Avg Quality Score

161 Meta Analysis

68 Systematic Review

51 Rct

48 Clinical Trial

2 Other

2 Regulatory Source

1 Narrative Review

1 Cochrane Review

1 Guideline

1 Openfda Safety

A Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age

Meta Analysis The Cochrane database of systematic reviews 2017

PubMed DOI Cochrane

A Vitamin A supplementation for the prevention of morbidity and mortality in infants six months of age or less

Meta Analysis The Cochrane database of systematic reviews 2011

PubMed DOI Cochrane

A Vitamin A supplementation for reducing the risk of mother-to-child transmission of HIV infection

Meta Analysis The Cochrane database of systematic reviews 2011

PubMed DOI Cochrane

A Vitamin A supplements for preventing mortality, illness, and blindness in children aged under 5: systematic review and meta-analysis

Meta Analysis BMJ (Clinical research ed.) 2011

PubMed DOI

A Fortification of staple foods with vitamin A for vitamin A deficiency

Systematic Review The Cochrane database of systematic reviews 2019

PubMed DOI Cochrane

A Vitamin A supplementation for the prevention of morbidity and mortality in infants one to six months of age

Narrative Review The Cochrane database of systematic reviews 2016

PubMed DOI Cochrane

A Vitamin A and fish oils for preventing the progression of retinitis pigmentosa

Meta Analysis The Cochrane database of systematic reviews 2020

PubMed DOI

A Exercise training-induced changes in exerkine concentrations may be relevant to the metabolic control of type 2 diabetes mellitus patients: A systematic review and meta-analysis of randomized controlled trials

Meta Analysis Journal of sport and health science 2023

PubMed DOI

A Food fortification with multiple micronutrients: impact on health outcomes in general population

Meta Analysis The Cochrane database of systematic reviews 2019

PubMed DOI

A Oral vitamin A supplements to prevent acute upper respiratory tract infections in children up to seven years of age

Meta Analysis The Cochrane database of systematic reviews 2024

PubMed DOI

View all evidence for Vitamin A →