Choline Cocktail by Twinlab — Ingredients, Evidence & Safety

🟢 100/100

This product looks safe

No ingredients exceed tolerable upper intake levels
62% of ingredients have research evidence

A Label Compliance Grade

Product Label

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Label Data

4 Tbsp Serving Size

9 Servings

Other Combinations Product Type

62% Evidence Coverage

Supplement Facts — Evidence Check

Calories

130 {Calories}

Total Carbohydrates

32 g (11% DV)

Sugar

7 g

Vitamin A

11000 IU (220% DV)

Vitamin C

1000 mg (1667% DV)

Vitamin E

400 IU (1333% DV)

📊 17.9× RDA — above typical dose (UL: 1000 mg) 📚 177 studies (Tier A: 3, B: 90)

RDA 15mg This product: 268.0mg UL 1000mg

Thiamine

1.5 mg (100% DV)

✅ 1.2× RDA — within safe limits 📚 76 studies (Tier A: 0, B: 33)

RDA 1.2mg This product: 1.5mg

Riboflavin

1.9 mg (112% DV)

✅ 1.5× RDA — within safe limits 📚 12 studies (Tier A: 0, B: 1)

RDA 1.3mg This product: 1.9mg

Niacin

20 mg (100% DV)

✅ 1.4× RDA — within safe limits 📚 193 studies (Tier A: 5, B: 63)

RDA 14mg This product: 20mg UL 35mg

Vitamin B6

2 mg (100% DV)

✅ 1.5× RDA — within safe limits 📚 113 studies (Tier A: 3, B: 35)

RDA 1.3mg This product: 2mg UL 100mg

Folic Acid

400 mcg (100% DV)

✅ Within RDA (1.0× RDA of 0.4 mg) 📚 225 studies (Tier A: 10, B: 105)

RDA 0.4mg This product: 0.4mg UL 1.0mg

Vitamin B12

1000 mcg (16667% DV)

📊 416.7× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)

RDA 0.0024mg This product: 1.0mg

Biotin

300 mcg (100% DV)

📊 10.0× RDA — above typical dose 📚 26 studies (Tier A: 0, B: 11)

RDA 0.03mg This product: 0.3mg

Pantothenic Acid

100 mg (1000% DV)

📊 20.0× RDA — above typical dose 📚 1 studies — no high-quality reviews

RDA 5mg This product: 100mg

Chromium

100 mcg (83% DV)

✅ 2.9× RDA — within safe limits 📚 197 studies (Tier A: 1, B: 55)

RDA 0.035mg This product: 0.1mg

Choline

1500 mg

✅ 2.7× RDA — within safe limits 📚 36 studies (Tier A: 1, B: 7)

RDA 550mg This product: 1500mg UL 3500mg

Guarana Seed Extract

750 mg

📊 Market median: 495.0mg (70 products)

Median 495.0mg This product: 750mg

DMAE

100 mg

L-Carnitine

100 mg

📊 Market median: 500.0mg (861 products) 📚 60 studies (Tier A: 4, B: 13)

This product: 100mg

Ginkgo biloba leaf extract

60 mg

📊 Market median: 120.0mg (440 products) 📚 187 studies (Tier A: 1, B: 71)

This product: 60mg

Co-Enzyme Q10

15 mg

📊 Market median: 100.0mg (283 products) 📚 142 studies (Tier A: 1, B: 64)

This product: 15mg UL 1200mg

Other Ingredients

Maltodextrin Fructose Citric Acid Silica Orange flavor Stevia leaf extract Soy Lecithin

Label Claims — Verification

❓ Nutrient

❓ All Other

All Other (97% of products) Structure/Function (90% of products) Nutrient (42% of products)

Target Groups

Adult (18 - 50 Years)

Product Information

📋 Directions for Use

DIRECTIONS: As a dietary supplement, for best results, take 1 serving upon awakening in the morning in place of coffee. Do not exceed 2 servings per day. Simply add 4 tablespoonfuls to 8 fl. oz. of cold water. Stir and serve. It may also be mixed for 10 seconds in a blender with crushed ice.

⚠️ Warnings & Precautions

KEEP OUT OF REACH OF CHILDREN.

WARNING: Diabetics may use only under a physician’s supervision, as this product contains chromium picolinate which may enhance insulin sensitivity. Discontinue use of this product at least 2 weeks pror to any surgery. Guarana extract contains caffeine and should not be taken by those wishing to eliminate caffeine from their diet.

🧪 Formulation Notes

Contains pure crystalline nutrients.

Energy Drink With DMAE & Ginkgo Biloba

No preservatives, artificial colors or flavors.

Additional Information

Keep tightly closed in a cool, dry place. Do not refrigerate.

2151783.3

Best if used by date shown on bottle.

Packaged in a glass bottle for maximum stability, quality and freshness.

Powder

Some settling may occur in shipping and handling.

This product is sold by weight only, not by volume.

Product Details

UPC / SKU 0 27434 00670 5

DSLD Entry Date 2011-12-23

Product Type Other Combinations

Form Liquid

Brand Twinlab

DSLD ID 3657

Data Updated 2026-04-11

Research Evidence

28 Research Sources

47 Avg Quality Score

11 Clinical Trial

8 Rct

2 Guideline

2 Meta Analysis

2 Regulatory Source

1 Systematic Review

1 Openfda Safety

B Greater Choline-Containing Compounds and Myo-inositol in Treatment-Resistant Versus Responsive Schizophrenia: A 1H-Magnetic Resonance Spectroscopy Meta-analysis

Meta Analysis Biological psychiatry. Cognitive neuroscience and neuroimaging 2024

PubMed DOI

B Integrating multi-structure covalent docking with machine-learning consensus scoring enhances potency ranking of human acetylcholinesterase inhibitors.

Guideline Briefings in bioinformatics 2026

PubMed DOI

B Evidence-based clinical practice guidelines for functional dyspepsia 2021.

Guideline Journal of gastroenterology 2022

PubMed DOI

B Scientific Opinion on health claims related to choline

Regulatory Source EFSA Journal 2011

DOI

C Effectiveness of nutritional interventions to prevent nonprogressive congenital and perinatal brain injuries: a systematic review and meta-analysis of randomized trials

Meta Analysis Nutrition reviews 2022

PubMed DOI

C Two methods for assessment of choline status in a randomized crossover study with varying dietary choline intake in people: isotope dilution MS of plasma and in vivo single-voxel magnetic resonance spectroscopy of liver.

Rct The American journal of clinical nutrition

PubMed DOI

C Choline and betaine concentrations in plasma discriminate levels of dietary choline intake in healthy adults: analysis of a double-blind randomized crossover controlled feeding study.

Rct The American journal of clinical nutrition

PubMed DOI

C Nutrient-based therapies for bipolar disorder: a systematic review

Systematic Review Psychotherapy and psychosomatics 2013

PubMed DOI

C The association of betaine, homocysteine and related metabolites with cognitive function in Dutch elderly people

Rct The British journal of nutrition 2007

PubMed

C Differential metabolism of choline supplements in adult volunteers.

Rct European journal of nutrition

PubMed DOI

View all evidence for Choline →