99/100
This product looks safe
- Manganese: 60mg is 5.5× the Tolerable Upper Intake Level (11mg)
- 52% of ingredients have research evidence
C
Label Compliance Grade
What the Evidence Says
✨ AI-generated · Qwen 3.6
· methodology
This formula contains minerals and nutrients like magnesium and selenium that support cardiovascular and metabolic functions. Research provides moderate to strong evidence for the roles of these ingredients in maintaining heart health. However, overall evidence coverage for this specific combination is limited.
AI-generated summary based on research evidence. Not medical advice.
Alerts
Safety Alerts
Manganese: 60mg is 5.5× the Tolerable Upper Intake Level (11mg)
Details
Label Data
6 Vegetable Capsule(s)
Serving Size
Other Combinations
Product Type
Ingredients
Supplement Facts — Evidence Check
Within RDA (0.2× RDA)
38 studies (A:1, B:7)
Within RDA (0.2× RDA)
316 studies (A:8, B:159)
Within RDA (0.2× RDA)
173 studies (A:0, B:67)
Exceeds UL by 5.5× (UL: 11 mg)
9 studies — no high-quality reviews
ChromeMate CM-100
22 mcg
(63% DV)
Ethylenediaminetetraacetic Acid
402 mg
Market median: 100.0mg (283 products)
144 studies (A:1, B:64)
Market median: 200.0mg (198 products)
6 studies — no high-quality reviews
Market median: 500.0mg (180 products)
5 studies (A:0, B:1)
Market median: 333.0mg (166 products)
9 studies (A:0, B:2)
Market median: 500.0mg (861 products)
61 studies (A:4, B:13)
Market median: 200.0mg (136 products)
3 studies — no high-quality reviews
Market median: 550.0mg (217 products)
29 studies (A:0, B:5)
Market median: 500.0mg (193 products)
7 studies — no high-quality reviews
Market median: 500.0mg (223 products)
24 studies (A:0, B:1)
Market median: 120.0mg (440 products)
191 studies (A:1, B:71)
Market median: 500.0mg (497 products)
135 studies (A:0, B:40)
Butcher's Broom Root Extract
150 mg
Other Ingredients
Rice Flour
Hypromellose
Water, Purified
Claims
Label Claims — Verification
Unverified
All Other
Unverified
Structure/Function
Info
Product Information
Directions for Use
Recommendations: Take six (6) capsules daily, or as directed by your physician.
Warnings & Precautions
Warning: If you are pregnant or breast feeding, consult your physician before using this product.
Keep out of reach of children.
For professional use only.
Formulation Notes
Contains no preservatives.
Bisphenol-A (BPA) & Phthalate Free
Vegetarian formulation
Non-GMO
Additional Information
Keep container tightly closed, store in a cool, dry place.
GMP Certified
Metadata
Product Details
UPC / SKU8 15354 02033 4
DSLD Entry Date2024-07-25
Product TypeOther Combinations
FormCapsule
Data Updated2026-04-11
Research
Research Evidence
B
Greater Choline-Containing Compounds and Myo-inositol in Treatment-Resistant Versus Responsive Schizophrenia: A 1H-Magnetic Resonance Spectroscopy Meta-analysis
Meta Analysis
Biological psychiatry. Cognitive neuroscience and neuroimaging
2024
PubMed
DOI
B
Integrating multi-structure covalent docking with machine-learning consensus scoring enhances potency ranking of human acetylcholinesterase inhibitors.
Guideline
Briefings in bioinformatics
2026
PubMed
DOI
B
Evidence-based clinical practice guidelines for functional dyspepsia 2021.
Guideline
Journal of gastroenterology
2022
PubMed
DOI
B
Scientific Opinion on health claims related to choline
Regulatory Source
EFSA Journal
2011
DOI
C
Effectiveness of nutritional interventions to prevent nonprogressive congenital and perinatal brain injuries: a systematic review and meta-analysis of randomized trials
Meta Analysis
Nutrition reviews
2022
PubMed
DOI
C
Two methods for assessment of choline status in a randomized crossover study with varying dietary choline intake in people: isotope dilution MS of plasma and in vivo single-voxel magnetic resonance spectroscopy of liver.
Rct
The American journal of clinical nutrition
PubMed
DOI
C
Choline and betaine concentrations in plasma discriminate levels of dietary choline intake in healthy adults: analysis of a double-blind randomized crossover controlled feeding study.
Rct
The American journal of clinical nutrition
PubMed
DOI
C
Nutrient-based therapies for bipolar disorder: a systematic review
Systematic Review
Psychotherapy and psychosomatics
2013
PubMed
DOI
C
The association of betaine, homocysteine and related metabolites with cognitive function in Dutch elderly people
Rct
The British journal of nutrition
2007
PubMed
C
Differential metabolism of choline supplements in adult volunteers.
View all evidence for Choline →
This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.
