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Prenatal All-in-One Softgel Folic Acid + DHA + Choline

product on market Softgel Capsule Nature Made Safety: 98/100
98/100

This product looks safe

  • Folate: 665mg is 665.0× the Tolerable Upper Intake Level (1.0mg)
  • 70% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

This formula contains essential vitamins A, C, D3, and E, which support immune function and cellular protection. Strong clinical evidence supports the role of these nutrients in maintaining overall maternal and fetal health. The product maintains a high safety profile for general prenatal use.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folate: 665mg is 665.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for Prenatal All-in-One Softgel Folic Acid + DHA + Choline
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Softgel(s)
Serving Size
60
Servings
Other Combinations
Product Type
70%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Calories
5 Calorie(s)
Vitamin A
650 mcg (50% DV)
Vitamin C
85 mg (71% DV)
25 mcg (167% DV)
1.7× RDA — within safe limits 608 studies (A:16, B:251)
15 mg (79% DV)
Within RDA (1.0× RDA) 179 studies (A:3, B:90)
90 mcg (100% DV)
Within RDA (0.8× RDA) 275 studies (A:9, B:175)
1.4 mg (88% DV)
1.1× RDA — within safe limits 13 studies (A:0, B:1)
18 mg (100% DV)
1.3× RDA — within safe limits 196 studies (A:5, B:63)
1.9 NP (95% DV)
1.5× RDA — within safe limits 114 studies (A:3, B:35)
665 mcg DFE (111% DV)
Exceeds UL by 665.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
5.2 mcg (186% DV)
2.2× RDA — within safe limits 139 studies (A:1, B:44)
30 mcg (86% DV)
Within RDA (1.0× RDA) 27 studies (A:0, B:11)
6 mg (86% DV)
1.2× RDA — within safe limits 2 studies — no high-quality reviews
55 mg (10% DV)
Within RDA (0.1× RDA) 38 studies (A:1, B:7)
Calcium
130 mg (10% DV)
Iron
27 mg (100% DV)
150 mcg (52% DV)
Within RDA (1.0× RDA) 245 studies (A:4, B:133)
40 mg (10% DV)
Within RDA (0.1× RDA) 316 studies (A:8, B:159)
11 mg (85% DV)
Within RDA (1.0× RDA) 263 studies (A:6, B:134)
Market median: 750.0mg (447 products) 393 studies (A:18, B:204)

Other Ingredients

Gelatin Glycerin Soybean Oil Rapeseed Lecithin Dibasic Calcium Phosphate Tocopherols Ascorbyl Palmitate
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested use: Adults, take 1 softgel daily with water and a meal for optimal absorption.

Warnings & Precautions

Store tightly closed, in a cool, dry place, out of reach of children.

Do not use if seal under cap is broken or missing.

Caution: If you are taking medication or have blood clotting issues, consult your physician before use.

Warning: Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6. Keep this product out of reach of children. In case of accidental overdose, call a doctor or poison control center immediately.

Formulation Notes

Clinically proven absorption of Folic Acid and Iron Folic Acid plays a critical role in the proper development of baby's nervous system and is an essential B vitamin for women. Iron is an essential mineral for the development of baby's brain during pregnancy, and for women during their reproductive years. Nature Made Prenatal All-in-One Softgel is clinically proven to: 1 hr Boost Folic Acid levels in one hour 2 hr Boost iron levels in two hours Based on an 8-hour study, serum levels peaked at one and two hours for folate and iron, respectively. Nutrient levels may vary as they are distributed throughout the body.

Nature Made Prenatal All-in-One Softgel Choline supports baby's brain and spinal cord development Folate (as Folic Acid) supports development of baby's nervous system DHA helps support baby's brain and eye development 17 additional key nutrients support mom's and baby's health 20 key nutrients for before and during pregnancy in one daily softgel

All in one softgel

DHA Choline Folic Acid Clinically proven absorption of folic acid & iron Multivitamin with 20 key nutrients

Brain Support Supports baby's brain and spinal cord development

No artificial flavors Gluten free

USP has tested and verified ingredients, potency and manufacturing process. USP sets official standards for dietary supplements. www.uspverified.org

Additional Information

Over 50 Years of Expertise New

USP Dietary Supplement Verified

Store tightly closed, in a cool, dry place, out of reach of children.

Metadata

Product Details

UPC / SKU0 31604 04334 6
DSLD Entry Date2023-08-23
Product TypeOther Combinations
FormSoftgel Capsule
BrandNature Made
DSLD ID287810
Data Updated2026-04-11
Research

Research Evidence

363
Research Sources
57
Avg Quality
187
Meta Analysis
56
Systematic Review
54
Rct
29
Guideline
26
Clinical Trial
6
Cochrane Review
2
Regulatory Source
1
Other
1
Openfda Safety
A Homocysteine-lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies
Meta Analysis Digestive diseases and sciences 2021 PubMed DOI
A The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis
Meta Analysis Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2021 PubMed DOI
A A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis Nutrients 2024 PubMed DOI
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials
Meta Analysis Critical reviews in food science and nutrition 2022 PubMed DOI
A Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants
Meta Analysis Critical reviews in food science and nutrition 2023 PubMed DOI
A Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care
Meta Analysis The Cochrane database of systematic reviews 2025 PubMed DOI
View all evidence for Folate →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.