Prenatal All-in-One Softgel Folic Acid + DHA + Choline

product on market Softgel Capsule Nature Made 🟢 Safety: 98/100
Brand: Nature Made
🟢 98/100

This product looks safe

  • Folate: 665mg is 665.0× the Tolerable Upper Intake Level (1.0mg)
  • 70% of ingredients have research evidence
C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Folate: 665mg is 665.0× the Tolerable Upper Intake Level (1.0mg)

Label Data

1 Softgel(s) Serving Size
60 Servings
Other Combinations Product Type
70% Evidence Coverage

Supplement Facts — Evidence Check

Calories
5 Calorie(s)
Vitamin A
650 mcg (50% DV)
Vitamin C
85 mg (71% DV)
25 mcg (167% DV)
✅ 1.7× RDA — within safe limits 📚 604 studies (Tier A: 16, B: 251)
RDA 0.015mg This product: 0.025mg UL 0.1mg
15 mg (79% DV)
✅ Within RDA (1.0× RDA of 15 mg) 📚 177 studies (Tier A: 3, B: 90)
RDA 15mg This product: 15mg UL 1000mg
90 mcg (100% DV)
✅ Within RDA (0.8× RDA of 0.12 mg) 📚 273 studies (Tier A: 9, B: 175)
RDA 0.12mg This product: 0.09mg
1.4 mg (88% DV)
✅ 1.1× RDA — within safe limits 📚 12 studies (Tier A: 0, B: 1)
RDA 1.3mg This product: 1.4mg
18 mg (100% DV)
✅ 1.3× RDA — within safe limits 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 18mg UL 35mg
1.9 NP (95% DV)
✅ 1.5× RDA — within safe limits 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 1.9mg UL 100mg
665 mcg DFE (111% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 665.0× (UL: 1.0 mg) 📚 225 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 665mg UL 1.0mg
5.2 mcg (186% DV)
✅ 2.2× RDA — within safe limits 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 0.0052mg
30 mcg (86% DV)
✅ Within RDA (1.0× RDA of 0.03 mg) 📚 26 studies (Tier A: 0, B: 11)
RDA 0.03mg This product: 0.03mg
6 mg (86% DV)
✅ 1.2× RDA — within safe limits 📚 1 studies — no high-quality reviews
RDA 5mg This product: 6mg
55 mg (10% DV)
✅ Within RDA (0.1× RDA of 550 mg) 📚 36 studies (Tier A: 1, B: 7)
RDA 550mg This product: 55mg UL 3500mg
Calcium
130 mg (10% DV)
Iron
27 mg (100% DV)
150 mcg (52% DV)
✅ Within RDA (1.0× RDA of 0.15 mg) 📚 243 studies (Tier A: 4, B: 133)
RDA 0.15mg This product: 0.15mg UL 1.1mg
40 mg (10% DV)
📊 Market median: 4002.0mg (1 products) 📚 20 studies (Tier A: 0, B: 2)
This product: 40mg
11 mg (85% DV)
✅ Within RDA (1.0× RDA of 11 mg) 📚 258 studies (Tier A: 6, B: 134)
RDA 11mg This product: 11mg UL 40mg
260 mg
📊 Market median: 750.0mg (447 products) 📚 388 studies (Tier A: 18, B: 204)
This product: 260mg UL 3000mg

Other Ingredients

Gelatin Glycerin Soybean Oil Rapeseed Lecithin Dibasic Calcium Phosphate Tocopherols Ascorbyl Palmitate

Label Claims — Verification

❓ Nutrient
❓ All Other
❓ Structure/Function
All Other (99% of products) Structure/Function (77% of products) Nutrient (60% of products) Approved Health (5% of products)

Target Groups

Pregnant Women Adult Female (18 - 50 Years) Lactating Gluten Free

Product Information

📋 Directions for Use

Suggested use: Adults, take 1 softgel daily with water and a meal for optimal absorption.

⚠️ Warnings & Precautions

Store tightly closed, in a cool, dry place, out of reach of children.

Do not use if seal under cap is broken or missing.

Caution: If you are taking medication or have blood clotting issues, consult your physician before use.

Warning: Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6. Keep this product out of reach of children. In case of accidental overdose, call a doctor or poison control center immediately.

🧪 Formulation Notes

Clinically proven absorption of Folic Acid and Iron Folic Acid plays a critical role in the proper development of baby's nervous system and is an essential B vitamin for women. Iron is an essential mineral for the development of baby's brain during pregnancy, and for women during their reproductive years. Nature Made Prenatal All-in-One Softgel is clinically proven to: 1 hr Boost Folic Acid levels in one hour 2 hr Boost iron levels in two hours Based on an 8-hour study, serum levels peaked at one and two hours for folate and iron, respectively. Nutrient levels may vary as they are distributed throughout the body.

Nature Made Prenatal All-in-One Softgel Choline supports baby's brain and spinal cord development Folate (as Folic Acid) supports development of baby's nervous system DHA helps support baby's brain and eye development 17 additional key nutrients support mom's and baby's health 20 key nutrients for before and during pregnancy in one daily softgel

All in one softgel

DHA Choline Folic Acid Clinically proven absorption of folic acid & iron Multivitamin with 20 key nutrients

Brain Support Supports baby's brain and spinal cord development

No artificial flavors Gluten free

USP has tested and verified ingredients, potency and manufacturing process. USP sets official standards for dietary supplements. www.uspverified.org

Additional Information

Over 50 Years of Expertise New

USP Dietary Supplement Verified

Store tightly closed, in a cool, dry place, out of reach of children.

Product Details

UPC / SKU 0 31604 04334 6
DSLD Entry Date 2023-08-23
Product Type Other Combinations
Form Softgel Capsule
Brand Nature Made
DSLD ID 287810
Data Updated 2026-04-11

Research Evidence

363 Research Sources
57 Avg Quality Score
187 Meta Analysis
56 Systematic Review
54 Rct
29 Guideline
26 Clinical Trial
6 Cochrane Review
2 Regulatory Source
1 Other
1 Openfda Safety
A Homocysteine-lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017
PubMed DOI
A Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015
PubMed DOI
A Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies
Meta Analysis Digestive diseases and sciences 2021
PubMed DOI
A The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis
Meta Analysis Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2021
PubMed DOI
A A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis Nutrients 2024
PubMed DOI
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025
PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019
PubMed DOI
A Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials
Meta Analysis Critical reviews in food science and nutrition 2022
PubMed DOI
A Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants
Meta Analysis Critical reviews in food science and nutrition 2023
PubMed DOI
A Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care
Meta Analysis The Cochrane database of systematic reviews 2025
PubMed DOI
View all evidence for Folate →

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