Prenatal Folic Acid + DHA by Nature Made — Ingredients, Evidence & Safety

🟢 98/100

This product looks safe

Folate: 1330mg is 1330.0× the Tolerable Upper Intake Level (1.0mg)
70% of ingredients have research evidence

C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Folate: 1330mg is 1330.0× the Tolerable Upper Intake Level (1.0mg)

Label Data

1 Softgel(s) Serving Size

Other Combinations Product Type

70% Evidence Coverage

Supplement Facts — Evidence Check

Calories

5 Calorie(s)

Vitamin A

770 mcg (59% DV)

Vitamin C

85 mg (71% DV)

Vitamin D3

25 mcg (167% DV)

✅ 1.7× RDA — within safe limits 📚 604 studies (Tier A: 16, B: 251)

RDA 0.015mg This product: 0.025mg UL 0.1mg

Vitamin E

15 mg (79% DV)

✅ Within RDA (1.0× RDA of 15 mg) 📚 177 studies (Tier A: 3, B: 90)

RDA 15mg This product: 15mg UL 1000mg

Vitamin K

90 mcg (100% DV)

✅ Within RDA (0.8× RDA of 0.12 mg) 📚 273 studies (Tier A: 9, B: 175)

RDA 0.12mg This product: 0.09mg

Thiamine

1.4 mg (100% DV)

✅ 1.2× RDA — within safe limits 📚 76 studies (Tier A: 0, B: 33)

RDA 1.2mg This product: 1.4mg

Riboflavin

1.4 mg (88% DV)

✅ 1.1× RDA — within safe limits 📚 12 studies (Tier A: 0, B: 1)

RDA 1.3mg This product: 1.4mg

Niacin

18 mg (100% DV)

✅ 1.3× RDA — within safe limits 📚 193 studies (Tier A: 5, B: 63)

RDA 14mg This product: 18mg UL 35mg

Vitamin B6

1.9 mg (95% DV)

✅ 1.5× RDA — within safe limits 📚 113 studies (Tier A: 3, B: 35)

RDA 1.3mg This product: 1.9mg UL 100mg

Folate

1330 mcg DFE (222% DV)

⚠️ Exceeds Tolerable Upper Intake Level by 1330.0× (UL: 1.0 mg) 📚 225 studies (Tier A: 10, B: 105)

RDA 0.4mg This product: 1330mg UL 1.0mg

Vitamin B12

5.2 mcg (186% DV)

✅ 2.2× RDA — within safe limits 📚 138 studies (Tier A: 1, B: 44)

RDA 0.0024mg This product: 0.0052mg

Biotin

30 mcg (86% DV)

✅ Within RDA (1.0× RDA of 0.03 mg) 📚 26 studies (Tier A: 0, B: 11)

RDA 0.03mg This product: 0.03mg

Pantothenic Acid

6 mg (86% DV)

✅ 1.2× RDA — within safe limits 📚 1 studies — no high-quality reviews

RDA 5mg This product: 6mg

Calcium

150 mg (12% DV)

Iron

27 mg (100% DV)

Iodine

150 mcg (52% DV)

✅ Within RDA (1.0× RDA of 0.15 mg) 📚 243 studies (Tier A: 4, B: 133)

RDA 0.15mg This product: 0.15mg UL 1.1mg

Magnesium

45 mg (11% DV)

📊 Market median: 4002.0mg (1 products) 📚 20 studies (Tier A: 0, B: 2)

This product: 45mg

Zinc

11 mg (85% DV)

✅ Within RDA (1.0× RDA of 11 mg) 📚 258 studies (Tier A: 6, B: 134)

RDA 11mg This product: 11mg UL 40mg

Omega-3 Fatty Acids

260 mg

📊 Market median: 750.0mg (447 products) 📚 388 studies (Tier A: 18, B: 204)

This product: 260mg UL 3000mg

Other Ingredients

Gelatin Glycerin Lecithin Soybean Oil Dibasic Calcium Phosphate yellow Beeswax Tocopherols Resin Ascorbyl Palmitate

Label Claims — Verification

❓ Nutrient

❓ All Other

❓ Structure/Function

All Other (99% of products) Structure/Function (77% of products) Nutrient (60% of products) Approved Health (5% of products)

Target Groups

Pregnant Women Adult Female (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

1 per day

Suggested Use: Adults, take 1 softgel daily with water and a meal for optimal absorption.

⚠️ Warnings & Precautions

Do not use if imprinted seal under cap is broken or missing.

Caution: If you are taking medication or have blood clotting issues, consult your physician before use.

Warning: Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6. Keep this product out of reach of children. In case of accidental overdose, call a doctor or poison control center immediately.

Store tightly closed, in a cool, dry place, out of reach of children.

🧪 Formulation Notes

Clinically proven absorption of folic acid & iron

Multivitamin with 20 key nutrients

Supports the development of baby's brain, eyes & nervous system

No artificial flavors Gluten free

USP has tested and verified ingredients, potency and manufacturing process. USP sets official standards for dietary supplements. www.uspverified.org

Additional Information

Over 50 years of expertise

USP Dietary Supplement Verified

Everyday value

Store tightly closed, in a cool, dry place, out of reach of children.

Product Details

UPC / SKU 0 31604 04077 2

DSLD Entry Date 2023-10-24

Product Type Other Combinations

Form Softgel Capsule

Brand Nature Made

DSLD ID 280356

Data Updated 2026-04-11

Research Evidence

363 Research Sources

57 Avg Quality Score

187 Meta Analysis

56 Systematic Review

54 Rct

29 Guideline

26 Clinical Trial

6 Cochrane Review

2 Regulatory Source

1 Other

1 Openfda Safety

A Homocysteine-lowering interventions for preventing cardiovascular events

Meta Analysis The Cochrane database of systematic reviews 2017

PubMed DOI

A Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes

Meta Analysis The Cochrane database of systematic reviews 2015

PubMed DOI

A Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies

Meta Analysis Digestive diseases and sciences 2021

PubMed DOI

A The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis

Meta Analysis Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2021

PubMed DOI

A A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Meta Analysis Nutrients 2024

PubMed DOI

A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis

Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025

PubMed DOI

A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies

Meta Analysis Critical reviews in food science and nutrition 2019

PubMed DOI

A Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials

Meta Analysis Critical reviews in food science and nutrition 2022

PubMed DOI

A Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants

Meta Analysis Critical reviews in food science and nutrition 2023

PubMed DOI

A Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care

Meta Analysis The Cochrane database of systematic reviews 2025

PubMed DOI

View all evidence for Folate →