Folate Methylation
94/100
This product looks safe
- Niacin: 50mg is 1.4× the Tolerable Upper Intake Level (35mg)
- Folate: 991mg is 991.0× the Tolerable Upper Intake Level (1.0mg)
- 75% of ingredients have research evidence
D
Label Compliance Grade
Product Label
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Safety Alerts
⚠️ Niacin: 50mg is 1.4× the Tolerable Upper Intake Level (35mg)
⚠️ Folate: 991mg is 991.0× the Tolerable Upper Intake Level (1.0mg)
Label Data
2 Vegetarian Capsule(s)
Serving Size
30
Servings
Other Combinations
Product Type
75%
Evidence Coverage
Supplement Facts — Evidence Check
49 mg
(4104% DV)
📊 40.8× RDA — above typical dose
📚 76 studies (Tier A: 0, B: 33)
50 mg
(3846% DV)
📊 38.5× RDA — above typical dose
📚 12 studies (Tier A: 0, B: 1)
50 mg NE
(313% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 1.4× (UL: 35 mg)
📚 193 studies (Tier A: 5, B: 63)
30 mg
(1765% DV)
📊 23.1× RDA — above typical dose (UL: 100 mg)
📚 113 studies (Tier A: 3, B: 35)
991 mcg DFE
(248% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 991.0× (UL: 1.0 mg)
📚 225 studies (Tier A: 10, B: 105)
1000 mcg
(41667% DV)
📊 416.7× RDA — above typical dose
📚 138 studies (Tier A: 1, B: 44)
1000 mcg
(3333% DV)
📊 33.3× RDA — above typical dose
📚 26 studies (Tier A: 0, B: 11)
50 mg
(1000% DV)
📊 10.0× RDA — above typical dose
📚 1 studies — no high-quality reviews
3 mg
(1% DV)
📊 Market median: 125.0mg (294 products)
📚 36 studies (Tier A: 1, B: 7)
2 mg
(14% DV)
✅ Within RDA (0.2× RDA of 11 mg)
📚 258 studies (Tier A: 6, B: 134)
500 mg
📊 Market median: 496.0mg (192 products)
📚 20 studies — no high-quality reviews
100 mg
📊 Market median: 100.0mg (108 products)
Other Ingredients
Rice Chelate
Silicon Dioxide
Sodium Sulfate
Hypromellose
Water, Purified
Label Claims — Verification
❓
All Other
❓
Structure/Function
All Other (99% of products)
Structure/Function (77% of products)
Nutrient (60% of products)
Approved Health (5% of products)
Target Groups
Vegetarian
Adult (18 - 50 Years)
Product Information
⚠️ Warnings & Precautions
Warning: If you are pregnant or breast feeding, consult your physician before using this product.
Recommendations: Take two (2) capsules daily, or as directed by your physician.
Keep out of reach of children.
Contains: Soy (phosphatidylcholine, phosphatidylserine)
🧪 Formulation Notes
Contains no preservatives.
Vegetarian formulation
Additional Information
Keep container tightly closed, store in a cool, dry place.
Bisphenol-A (BPA) & Phthalate Free
For professional use only.
Product Details
UPC / SKU
8 15354 02055 6
DSLD Entry Date
2022-11-22
Product Type
Other Combinations
Form
Capsule
DSLD ID
277360
Data Updated
2026-04-11
Research Evidence
363
Research Sources
57
Avg Quality Score
187
Meta Analysis
56
Systematic Review
54
Rct
29
Guideline
26
Clinical Trial
6
Cochrane Review
2
Regulatory Source
1
Other
1
Openfda Safety
A
Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes
A
Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies
A
The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis
A
A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
A
Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
A
Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
A
Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials
A
Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants
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