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Folate Methylation

product on market Capsule Priority One Nutritional Supplements Safety: 94/100
94/100

This product looks safe

  • Niacin: 50mg is 1.4× the Tolerable Upper Intake Level (35mg)
  • Folate: 991mg is 991.0× the Tolerable Upper Intake Level (1.0mg)
  • 75% of ingredients have research evidence
D Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

This profile contains B vitamins, including folate and thiamine, which are supported by strong evidence for supporting cellular energy metabolism and neurological function. These nutrients act as essential cofactors in methylation processes throughout the body. The formulation maintains a high safety score, indicating a low risk of adverse effects for most users.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Niacin: 50mg is 1.4× the Tolerable Upper Intake Level (35mg)

Folate: 991mg is 991.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for Folate Methylation
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Vegetarian Capsule(s)
Serving Size
30
Servings
Other Combinations
Product Type
75%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

49 mg (4104% DV)
40.8× RDA — above typical dose 76 studies (A:0, B:33)
50 mg (3846% DV)
38.5× RDA — above typical dose 13 studies (A:0, B:1)
50 mg NE (313% DV)
Exceeds UL by 1.4× (UL: 35 mg) 196 studies (A:5, B:63)
30 mg (1765% DV)
23.1× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
991 mcg DFE (248% DV)
Exceeds UL by 991.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
1000 mcg (41667% DV)
416.7× RDA — above typical dose 139 studies (A:1, B:44)
1000 mcg (3333% DV)
33.3× RDA — above typical dose 27 studies (A:0, B:11)
50 mg (1000% DV)
10.0× RDA — above typical dose 2 studies — no high-quality reviews
3 mg (1% DV)
Market median: 125.0mg (294 products) 38 studies (A:1, B:7)
2 mg (14% DV)
Within RDA (0.2× RDA) 263 studies (A:6, B:134)
Market median: 496.0mg (192 products) 20 studies — no high-quality reviews
Market median: 100.0mg (108 products)

Other Ingredients

Rice Chelate Silicon Dioxide Sodium Sulfate Hypromellose Water, Purified
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Warnings & Precautions

Warning: If you are pregnant or breast feeding, consult your physician before using this product.

Recommendations: Take two (2) capsules daily, or as directed by your physician.

Keep out of reach of children.

Contains: Soy (phosphatidylcholine, phosphatidylserine)

Formulation Notes

Contains no preservatives.

Vegetarian formulation

Additional Information

Keep container tightly closed, store in a cool, dry place.

Bisphenol-A (BPA) & Phthalate Free

For professional use only.

Metadata

Product Details

UPC / SKU8 15354 02055 6
DSLD Entry Date2022-11-22
Product TypeOther Combinations
FormCapsule
BrandPriority One Nutritional Supplements
DSLD ID277360
Data Updated2026-04-11
Research

Research Evidence

363
Research Sources
57
Avg Quality
187
Meta Analysis
56
Systematic Review
54
Rct
29
Guideline
26
Clinical Trial
6
Cochrane Review
2
Regulatory Source
1
Other
1
Openfda Safety
A Homocysteine-lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies
Meta Analysis Digestive diseases and sciences 2021 PubMed DOI
A The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis
Meta Analysis Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2021 PubMed DOI
A A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis Nutrients 2024 PubMed DOI
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials
Meta Analysis Critical reviews in food science and nutrition 2022 PubMed DOI
A Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants
Meta Analysis Critical reviews in food science and nutrition 2023 PubMed DOI
A Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care
Meta Analysis The Cochrane database of systematic reviews 2025 PubMed DOI
View all evidence for Folate →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.