L-5-MTHF Natural S-Isomer
100/100
This product looks safe
- No ingredients exceed tolerable upper intake levels
- 100% of ingredients have research evidence
A
Label Compliance Grade
Product Label
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Label Data
1 Capsule(s)
Serving Size
Other Combinations
Product Type
100%
Evidence Coverage
Supplement Facts — Evidence Check
1000 mcg
(250% DV)
✅ 2.5× RDA — within safe limits
📚 225 studies (Tier A: 10, B: 105)
Other Ingredients
Microcrystalline Cellulose
spinach juice powder
L-Leucine
Label Claims — Verification
❓
All Other
All Other (99% of products)
Structure/Function (77% of products)
Nutrient (60% of products)
Approved Health (5% of products)
Target Groups
Adult (18 - 50 Years)
Gluten Free
Product Information
📋 Directions for Use
Recommended Use: As a dietary supplement, take one capsule per day, or as directed by your health care practitioner.
⚠️ Warnings & Precautions
KEEP OUT OF REACH OF CHILDREN.
🧪 Formulation Notes
Does not contain gluten.
Methylsulfonylmethane
Additional Information
L-5- MTHF is the natural, biologically active form of folate. It offers the benefits of optimal folate supplementation without the potential risks associated with chronic exposure to unmetabolized synthetic folic acid.
Quatrefolic(R)
MADE WITH NON-GMO INGREDIENTS
STORE IN A COOL, DRY PLACE.
Notice: Color, size or shape may appear different between lots.
MTH120-2
For Professional Use Only
Guaranteed GMP CERTIFIED Products
Product Details
UPC / SKU
8 79452 00278 4
DSLD Entry Date
2013-07-25
Product Type
Other Combinations
Form
Capsule
Brand
Designs for Health
DSLD ID
22475
Data Updated
2026-04-11
Research Evidence
363
Research Sources
57
Avg Quality Score
187
Meta Analysis
56
Systematic Review
54
Rct
29
Guideline
26
Clinical Trial
6
Cochrane Review
2
Regulatory Source
1
Other
1
Openfda Safety
A
Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes
A
Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies
A
The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis
A
A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
A
Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
A
Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
A
Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials
A
Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants
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