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SAMe with Vitamins B-6, B-12 and 5-MTHF

product on market Capsule Designs for Health Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · grounded in 1 source · methodology

SAMe and B vitamins are supported by moderate to strong evidence for supporting mood regulation and methylation processes. Vitamin B-6, B-12, and folate act as essential cofactors in the synthesis of neurotransmitters. Research indicates these ingredients collectively support neurological function and emotional well-being.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for SAMe with Vitamins B-6, B-12 and 5-MTHF
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
Other Combinations
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

5 mg (250% DV)
3.8× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
100 mcg (25% DV)
Within RDA (0.2× RDA) 226 studies (A:10, B:105)
50 mcg (830% DV)
20.8× RDA — above typical dose 139 studies (A:1, B:44)
200 mg
Market median: 200.0mg (52 products) 12 studies (A:0, B:6)

Other Ingredients

Microcrystalline Cellulose Vegetable Stearate Calcium Chloride Anhydrous Calcium Oxide
Claims

Label Claims — Verification

Unverified All Other
Info

Product Information

Directions for Use

Recommended Use: As a dietary supplement, take one capsule per day, preferably on an empty stomach, or as directed by your health care practitioner.

Formulation Notes

Does not contain gluten.

Additional Information

SAM030

MADE WITH NON-GMO INGREDIENTS

Notice: Color, size or shape may appear different between lots.

For Professional Use Only

STORE IN A COOL, DRY PLACE.

Guaranteed GMP COMPLIANT Products

Metadata

Product Details

UPC / SKU8 79452 00378 1
DSLD Entry Date2013-06-25
Product TypeOther Combinations
FormCapsule
BrandDesigns for Health
DSLD ID22786
Data Updated2026-04-11
Research

Research Evidence

363
Research Sources
57
Avg Quality
187
Meta Analysis
56
Systematic Review
54
Rct
29
Guideline
26
Clinical Trial
6
Cochrane Review
2
Regulatory Source
1
Other
1
Openfda Safety
A Homocysteine-lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies
Meta Analysis Digestive diseases and sciences 2021 PubMed DOI
A The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis
Meta Analysis Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2021 PubMed DOI
A A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis Nutrients 2024 PubMed DOI
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials
Meta Analysis Critical reviews in food science and nutrition 2022 PubMed DOI
A Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants
Meta Analysis Critical reviews in food science and nutrition 2023 PubMed DOI
A Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care
Meta Analysis The Cochrane database of systematic reviews 2025 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.