SAMe with Vitamins B-6, B-12 and 5-MTHF
100/100
This product looks safe
- No ingredients exceed tolerable upper intake levels
- 100% of ingredients have research evidence
A
Label Compliance Grade
Product Label
Have a supplement label? Find it here.
Upload a photo of any supplement label to search our database of 92,312 products.
Label Data
1 Capsule(s)
Serving Size
Other Combinations
Product Type
100%
Evidence Coverage
Supplement Facts — Evidence Check
5 mg
(250% DV)
📊 3.8× RDA — above typical dose (UL: 100 mg)
📚 113 studies (Tier A: 3, B: 35)
100 mcg
(25% DV)
✅ Within RDA (0.2× RDA of 0.4 mg)
📚 225 studies (Tier A: 10, B: 105)
50 mcg
(830% DV)
📊 20.8× RDA — above typical dose
📚 138 studies (Tier A: 1, B: 44)
200 mg
📊 Market median: 200.0mg (52 products)
📚 10 studies (Tier A: 0, B: 6)
Other Ingredients
Microcrystalline Cellulose
Vegetable Stearate
Calcium Chloride Anhydrous
Calcium Oxide
Label Claims — Verification
❓
All Other
All Other (99% of products)
Structure/Function (77% of products)
Nutrient (60% of products)
Approved Health (5% of products)
Target Groups
Adult (18 - 50 Years)
Gluten Free
Product Information
📋 Directions for Use
Recommended Use: As a dietary supplement, take one capsule per day, preferably on an empty stomach, or as directed by your health care practitioner.
🧪 Formulation Notes
Does not contain gluten.
Additional Information
MADE WITH NON-GMO INGREDIENTS
SAM090
Guaranteed GMP COMPLIANT Products
STORE IN A COOL, DRY PLACE.
Notice: Color, size or shape may appear different between lots.
For Professional Use Only
Product Details
UPC / SKU
8 79452 00377 4
DSLD Entry Date
2013-06-25
Product Type
Other Combinations
Form
Capsule
Brand
Designs for Health
DSLD ID
22788
Data Updated
2026-04-11
Research Evidence
363
Research Sources
57
Avg Quality Score
187
Meta Analysis
56
Systematic Review
54
Rct
29
Guideline
26
Clinical Trial
6
Cochrane Review
2
Regulatory Source
1
Other
1
Openfda Safety
A
Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes
A
Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies
A
The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis
A
A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
A
Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
A
Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
A
Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials
A
Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants
Compare Similar Products
Bio-Plus Biotin With Folic Acid
Douglas Laboratories
100
Folic Acid
OL Olympian Labs
100
L-5-MTHF Natural S-Isomer
Designs for Health
100
Folic Acid
DaVinci Laboratories Of Vermont
100
SAMe with Vitamins B-6, B-12 and 5-MTHF
Designs for Health
100