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Ultra 5-HTP Formula

product on market Capsule Douglas Laboratories Safety: 98/100
98/100

This product looks safe

  • Niacinamide: 50mg is 1.4× the Tolerable Upper Intake Level (35mg)
  • 70% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

The formula contains vitamins A, C, and E, which act as antioxidants, alongside thiamine and riboflavin for metabolic support. There is strong evidence for the general roles of these vitamins in cellular health. However, the overall evidence coverage for this specific ingredient profile is limited.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Niacinamide: 50mg is 1.4× the Tolerable Upper Intake Level (35mg)

Label

Product Label

Label for Ultra 5-HTP Formula
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Capsule(s)
Serving Size
90
Servings
Other Combinations
Product Type
70%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Vitamin A
1000 IU (20% DV)
Vitamin C
100 mg (167% DV)
30 IU (100% DV)
1.3× RDA — within safe limits 179 studies (A:3, B:90)
5 mg (333% DV)
4.2× RDA — above typical dose 76 studies (A:0, B:33)
5 mg (294% DV)
3.8× RDA — above typical dose 13 studies (A:0, B:1)
50 mg (250% DV)
Exceeds UL by 1.4× (UL: 35 mg) 196 studies (A:5, B:63)
800 mcg (200% DV)
2.0× RDA — within safe limits 226 studies (A:10, B:105)
1000 mcg (16667% DV)
416.7× RDA — above typical dose 139 studies (A:1, B:44)
5 mg (50% DV)
Within RDA (1.0× RDA) 2 studies — no high-quality reviews
50 mg (13% DV)
Within RDA (0.1× RDA) 316 studies (A:8, B:159)
10 mg (67% DV)
Within RDA (0.9× RDA) 263 studies (A:6, B:134)
100 mcg (83% DV)
2.9× RDA — within safe limits 199 studies (A:1, B:55)
Market median: 100.0mg (116 products) 18 studies (A:0, B:3)
100 mg
Market median: 500.0mg (223 products) 24 studies (A:0, B:1)
100 mg
Market median: 420.0mg (227 products)
Octacosanol
1500 mcg
Market median: 300.0mg (240 products) 20 studies — no high-quality reviews
Market median: 120.0mg (440 products) 191 studies (A:1, B:71)
25 mg
Market median: 550.0mg (217 products) 29 studies (A:0, B:5)
15.4× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)

Other Ingredients

Cellulose Silica
Claims

Label Claims — Verification

Unverified All Other
Info

Product Information

Directions for Use

Suggested Usage: As a dietary supplement, adults take 2 capsules daily or as directed by physician.

Warnings & Precautions

KEEP OUT OF REACH OF CHILDREN.

TAMPER RESISTANT PACKAGE, DO NOT USE IF OUTER SEAL IS MISSING.

Formulation Notes

This product contains NO yeast, wheat gluten, soy protein, milk/dairy, corn, sodium, sugar, starch, artificial coloring, pre-servatives or flavoring.

Additional Information

STORE IN A COOL, DRY PLACE.

Formula #85080

Metadata

Product Details

DSLD Entry Date2012-06-25
Product TypeOther Combinations
FormCapsule
BrandDouglas Laboratories
DSLD ID10298
Data Updated2026-04-11
Research

Research Evidence

21
Research Sources
53
Avg Quality
11
Systematic Review
6
Rct
4
Meta Analysis
B Combination pharmacotherapy for the treatment of fibromyalgia in adults
Systematic Review The Cochrane database of systematic reviews 2018 PubMed DOI
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2001 PubMed
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2002 PubMed
B The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial
Rct Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
B The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial
Rct Nutrients 2025 PubMed DOI
B The Efficacy of Different Triptans for the Treatment of Acute Headache in Pediatric Migraine: A Systematic Review
Systematic Review Indian pediatrics 2023 PubMed
B The effect of therapeutic massage combined with conventional therapy in children with functional dyspepsia: a systematic review and meta-analysis
Systematic Review Frontiers in pharmacology 2025 PubMed DOI
C Sleep disorders in children
Systematic Review BMJ clinical evidence 2010 PubMed
C Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2020 PubMed DOI
C Investigating genetic links between biological aging and adverse pregnancy outcomes
Meta Analysis Biogerontology 2025 PubMed DOI
View all evidence for 5 Htp →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.