🟢 98/100

This product looks safe

  • Niacinamide: 50mg is 1.4× the Tolerable Upper Intake Level (35mg)
  • 70% of ingredients have research evidence
C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Niacinamide: 50mg is 1.4× the Tolerable Upper Intake Level (35mg)

Label Data

2 Capsule(s) Serving Size
90 Servings
Other Combinations Product Type
70% Evidence Coverage

Supplement Facts — Evidence Check

Vitamin A
1000 IU (20% DV)
Vitamin C
100 mg (167% DV)
30 IU (100% DV)
✅ 1.3× RDA — within safe limits 📚 177 studies (Tier A: 3, B: 90)
RDA 15mg This product: 20.1mg UL 1000mg
5 mg (333% DV)
📊 4.2× RDA — above typical dose 📚 76 studies (Tier A: 0, B: 33)
RDA 1.2mg This product: 5mg
5 mg (294% DV)
📊 3.8× RDA — above typical dose 📚 12 studies (Tier A: 0, B: 1)
RDA 1.3mg This product: 5mg
50 mg (250% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 1.4× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 50mg UL 35mg
800 mcg (200% DV)
✅ 2.0× RDA — within safe limits 📚 225 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 0.8mg UL 1.0mg
1000 mcg (16667% DV)
📊 416.7× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 1.0mg
5 mg (50% DV)
✅ Within RDA (1.0× RDA of 5 mg) 📚 1 studies — no high-quality reviews
RDA 5mg This product: 5mg
50 mg (13% DV)
📊 Market median: 4002.0mg (1 products) 📚 20 studies (Tier A: 0, B: 2)
This product: 50mg
10 mg (67% DV)
✅ Within RDA (0.9× RDA of 11 mg) 📚 258 studies (Tier A: 6, B: 134)
RDA 11mg This product: 10mg UL 40mg
100 mcg (83% DV)
✅ 2.9× RDA — within safe limits 📚 197 studies (Tier A: 1, B: 55)
RDA 0.035mg This product: 0.1mg
📊 Market median: 100.0mg (116 products) 📚 15 studies (Tier A: 0, B: 3)
This product: 125mg
100 mg
📊 Market median: 500.0mg (223 products) 📚 22 studies (Tier A: 0, B: 1)
This product: 100mg
100 mg
📊 Market median: 420.0mg (227 products)
Median 420.0mg This product: 100mg
Octacosanol
1500 mcg
📊 Market median: 300.0mg (240 products) 📚 11 studies — no high-quality reviews
This product: 30mg
📊 Market median: 120.0mg (440 products) 📚 187 studies (Tier A: 1, B: 71)
This product: 15mg
25 mg
📊 Market median: 550.0mg (217 products) 📚 29 studies (Tier A: 0, B: 5)
This product: 25mg
📊 15.4× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 20mg UL 100mg

Other Ingredients

Cellulose Silica

Label Claims — Verification

All Other
All Other (99% of products) Structure/Function (78% of products) Nutrient (52% of products)

Target Groups

Adult (18 - 50 Years) Dairy Free Sugar Free

Product Information

📋 Directions for Use

Suggested Usage: As a dietary supplement, adults take 2 capsules daily or as directed by physician.

⚠️ Warnings & Precautions

KEEP OUT OF REACH OF CHILDREN.

TAMPER RESISTANT PACKAGE, DO NOT USE IF OUTER SEAL IS MISSING.

🧪 Formulation Notes

This product contains NO yeast, wheat gluten, soy protein, milk/dairy, corn, sodium, sugar, starch, artificial coloring, pre-servatives or flavoring.

Additional Information

STORE IN A COOL, DRY PLACE.

Formula #85080

Product Details

DSLD Entry Date 2012-06-25
Product Type Other Combinations
Form Capsule
DSLD ID 10298
Data Updated 2026-04-11

Research Evidence

21 Research Sources
53 Avg Quality Score
11 Systematic Review
6 Rct
4 Meta Analysis
B Combination pharmacotherapy for the treatment of fibromyalgia in adults
Systematic Review The Cochrane database of systematic reviews 2018
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2001
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2002
B The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial
Rct Clinical nutrition (Edinburgh, Scotland) 2024
B The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial
Rct Nutrients 2025
B The Efficacy of Different Triptans for the Treatment of Acute Headache in Pediatric Migraine: A Systematic Review
Systematic Review Indian pediatrics 2023
B The effect of therapeutic massage combined with conventional therapy in children with functional dyspepsia: a systematic review and meta-analysis
Systematic Review Frontiers in pharmacology 2025
C Sleep disorders in children
Systematic Review BMJ clinical evidence 2010
C Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2020
C Investigating genetic links between biological aging and adverse pregnancy outcomes
Meta Analysis Biogerontology 2025
View all evidence for 5 Htp →

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