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Cogni Defend

product on market Capsule Clean Nutraceuticals Safety: 96/100
96/100

This product looks safe

  • Vitamin D3: 0.5mg is 5.0× the Tolerable Upper Intake Level (0.1mg)
  • Folate: 340mg is 340.0× the Tolerable Upper Intake Level (1.0mg)
  • 58% of ingredients have research evidence
D Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · methodology

This profile contains essential vitamins and folate, which are supported by strong evidence for maintaining cognitive function and immune health. These nutrients act as antioxidants and cofactors in neurological processes. However, the overall evidence coverage for this specific formulation is limited.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Vitamin D3: 0.5mg is 5.0× the Tolerable Upper Intake Level (0.1mg)

Folate: 340mg is 340.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for Cogni Defend
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Capsule(s)
Serving Size
30
Servings
Other Combinations
Product Type
58%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Vitamin C
90 mg (100% DV)
500 mcg (2500% DV)
Exceeds UL by 5.0× (UL: 0.1 mg) 608 studies (A:16, B:251)
15 mg (100% DV)
Within RDA (1.0× RDA) 179 studies (A:3, B:90)
2 mg (118% DV)
1.5× RDA — within safe limits 114 studies (A:3, B:35)
340 mcg DFE (85% DV)
Exceeds UL by 340.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
100 mcg (4167% DV)
41.7× RDA — above typical dose 139 studies (A:1, B:44)
Bacopa Whole Plant Extract
300 mg
Market median: 100.0mg (108 products)
Within RDA (0.5× RDA) 38 studies (A:1, B:7)
Market median: 1000.0mg (212 products) 12 studies (A:0, B:3)
100 mg
Market median: 200.0mg (358 products) 9 studies (A:0, B:2)
Market median: 120.0mg (440 products) 191 studies (A:1, B:71)
Market median: 450.0mg (130 products) 1 studies — no high-quality reviews
Lion's Mane Mushroom Fruiting Body Extract
50 mg
Knotweed Root Extract
50 mg
Market median: 600.0mg (7 products) 39 studies (A:2, B:13)
Market median: 99.0mg (503 products) 13 studies (A:0, B:3)
Black Pepper fruit extract
5 mg
400 mcg
Market median: 0.15mg (41 products)

Other Ingredients

Bovine Gelatin Maltodextrin Silicon Dioxide Rice Flour
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested use: As a dietary supplement take two (2) capsules once a day. For best results take with a meal and an 8 oz glass of water or as directed by your healthcare professional.

Warnings & Precautions

Caution: Do not exceed recommended dose.

Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.

Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement. Keep out of reach of children.

Do not use if safety seal is damaged or missing.

Formulation Notes

Transparency

Made in the United States with globally sourced ingredients.

Alpha GPC, phosphatidylserine, bacopa monnieri, huperzine-a & ginkgo biloba Each serving contains: Alpha GPC 300 mg, Phosphatidylserine, Bacopa Monnieri, Huperzine-A 400 mcg, L-Theanine 100 mg & more All-in-1 Supplement

Alpha GPC Phosphati Pd dylserine Bacopa Bm Monnieri Huperzine A Extract L-Theanine Lt Ginkgo Gb Biloba Omega 3 Flax Resveratrol R Extract Lions Mane Lm Mushroom Cats Claw Cc N-Acetyl- Nc - L-Cysteine Vitamin D3 Vitamin E Vitamin C Vitamin B6 Vitamin B12

Additional Information

Store in a cool, dry place.

Questions, compliments or concerns? Support@cleannutra.com

Metadata

Product Details

DSLD Entry Date2025-09-25
Product TypeOther Combinations
FormCapsule
DSLD ID335580
Data Updated2026-04-11
Research

Research Evidence

371
Research Sources
54
Avg Quality
148
Meta Analysis
82
Systematic Review
71
Rct
62
Clinical Trial
2
Regulatory Source
1
Cochrane Review
1
Narrative Review
1
Other
1
Openfda Safety
A Vitamin C supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Vitamin C supplementation for the primary prevention of cardiovascular disease
Systematic Review The Cochrane database of systematic reviews 2017 PubMed DOI
A Vitamin C for preventing and treating the common cold
Meta Analysis The Cochrane database of systematic reviews 2013 PubMed DOI
A Vitamin C for preventing and treating pneumonia
Meta Analysis The Cochrane database of systematic reviews 2013 PubMed DOI
A Vitamin E supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Vitamin C supplementation for prevention and treatment of pneumonia
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
A Vitamin C supplementation for prevention and treatment of pneumonia
Systematic Review The Cochrane database of systematic reviews 2021 PubMed DOI
A Nutritional interventions for preventing and treating pressure ulcers
Meta Analysis The Cochrane database of systematic reviews 2024 PubMed DOI
A Does Vitamin C Supplementation Provide a Protective Effect in Periodontal Health? A Systematic Review and Meta-Analysis
Meta Analysis International journal of molecular sciences 2024 PubMed DOI
A Circulating vitamin C concentration and risk of cancers: a Mendelian randomization study
Meta Analysis BMC medicine 2021 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.