Is 125 mg of Thiamine safe?

This is 104.2× the recommended daily intake of 1.2 mg. While above typical doses, it may still be within safe limits (UL: None mg).

Is 125 mg of Riboflavin safe?

This is 96.2× the recommended daily intake of 1.3 mg. While above typical doses, it may still be within safe limits (UL: None mg).

Is 125 mg NE of Niacin safe?

No — this amount exceeds the Tolerable Upper Intake Level of 35 mg by 3.6×. The recommended daily intake is 14 mg.

Is 125 mg of Vitamin B6 safe?

No — this amount exceeds the Tolerable Upper Intake Level of 100 mg by 1.2×. The recommended daily intake is 1.3 mg.

Ultra-Stress Sustained Release by NaturesPlus — Ingredients, Evidence & Safety

🟢 91/100

This product looks safe

Niacin: 125mg is 3.6× the Tolerable Upper Intake Level (35mg)
Vitamin B6: 125mg is 1.2× the Tolerable Upper Intake Level (100mg)
Folate: 667mg is 667.0× the Tolerable Upper Intake Level (1.0mg)
69% of ingredients have research evidence

F Label Compliance Grade

What the Evidence Says

This formula contains B vitamins and vitamin C, which are supported by strong evidence for supporting energy metabolism and cellular function during stress. These nutrients play key roles in neurotransmitter synthesis and antioxidant defense. The overall evidence coverage for this specific blend is limited.

AI-generated summary based on research evidence. Not medical advice.

Product Label

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Safety Alerts

⚠️ Niacin: 125mg is 3.6× the Tolerable Upper Intake Level (35mg)

⚠️ Vitamin B6: 125mg is 1.2× the Tolerable Upper Intake Level (100mg)

⚠️ Folate: 667mg is 667.0× the Tolerable Upper Intake Level (1.0mg)

Label Data

1 Tablet(s) Serving Size

30 Servings

Other Combinations Product Type

69% Evidence Coverage

Supplement Facts — Evidence Check

Vitamin C

500 mg (556% DV)

Thiamine

125 mg (10417% DV)

📊 104.2× RDA — above typical dose 📚 76 studies (Tier A: 0, B: 33)

RDA 1.2mg This product: 125mg

Riboflavin

125 mg (9615% DV)

📊 96.2× RDA — above typical dose 📚 13 studies (Tier A: 0, B: 1)

RDA 1.3mg This product: 125mg

Niacin

125 mg NE (781% DV)

⚠️ Exceeds Tolerable Upper Intake Level by 3.6× (UL: 35 mg) 📚 196 studies (Tier A: 5, B: 63)

RDA 14mg This product: 125mg UL 35mg

Vitamin B6

125 mg (7353% DV)

⚠️ Exceeds Tolerable Upper Intake Level by 1.2× (UL: 100 mg) 📚 114 studies (Tier A: 3, B: 35)

RDA 1.3mg This product: 125mg UL 100mg

Folate

667 mcg DFE (167% DV)

⚠️ Exceeds Tolerable Upper Intake Level by 667.0× (UL: 1.0 mg) 📚 226 studies (Tier A: 10, B: 105)

RDA 0.4mg This product: 667mg UL 1.0mg

Vitamin B12

500 mcg (20833% DV)

📊 208.3× RDA — above typical dose 📚 139 studies (Tier A: 1, B: 44)

RDA 0.0024mg This product: 0.5mg

Biotin

125 mcg (417% DV)

📊 4.2× RDA — above typical dose 📚 27 studies (Tier A: 0, B: 11)

RDA 0.03mg This product: 0.125mg

Pantothenic Acid

200 mg (4000% DV)

📊 40.0× RDA — above typical dose 📚 2 studies — no high-quality reviews

RDA 5mg This product: 200mg

Choline

32 mg (6% DV)

✅ Within RDA (0.1× RDA of 550 mg) 📚 38 studies (Tier A: 1, B: 7)

RDA 550mg This product: 32mg UL 3500mg

Iron

20 mg (111% DV)

Inositol

75 mg

📊 Market median: 550.0mg (217 products) 📚 29 studies (Tier A: 0, B: 5)

This product: 75mg

Para-Aminobenzoic Acid

50 mg

📊 Market median: 500.0mg (9 products) 📚 7 studies — no high-quality reviews

This product: 50mg

Other Ingredients

Hydroxypropyl Methylcellulose Stearic Acid Microcrystalline Cellulose Ferrous Fumarate Magnesium Stearate Rose Hip Soy Protein Isolate Rice Pharmaceutical Glaze

Label Claims — Verification

❓ Nutrient

❓ All Other

All Other (99% of products) Structure/Function (83% of products) Nutrient (54% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

Directions: One tablet daily, preferably with a meal.

⚠️ Warnings & Precautions

Warning: Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6. Keep this product out of reach of children. In case of accidental overdose, call a physician or poison control center immediately.