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3-in-1 Joint Formula

product on market Softgel Capsule Irwin Naturals Safety: 97/100
97/100

This product looks safe

  • Folate: 382mg is 382.0× the Tolerable Upper Intake Level (1.0mg)
  • Fish Oils: 3180mg is 1.1× the Tolerable Upper Intake Level (3000mg)
  • 46% of ingredients have research evidence
D Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · methodology

The listed top ingredients consist of basic macronutrients, which provide general energy and structural support for the body. There is strong evidence regarding the role of proteins and carbohydrates in maintaining overall health. However, these components do not provide targeted therapeutic effects for joint support.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folate: 382mg is 382.0× the Tolerable Upper Intake Level (1.0mg)

Fish Oils: 3180mg is 1.1× the Tolerable Upper Intake Level (3000mg)

Label

Product Label

Label for 3-in-1 Joint Formula
Open Full PDF View on NIH DSLD →
Details

Label Data

6 Liquid Softgel(s)
Serving Size
15
Servings
Other Combinations
Product Type
46%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Calories
60 Calorie(s)
Total Fat
3.5 Gram(s) (4% DV)
Cholesterol
15 mg (5% DV)
Total Carbohydrates
3 Gram(s) (1% DV)
Protein
3 Gram(s)
10 mg (67% DV)
Within RDA (0.7× RDA) 179 studies (A:3, B:90)
23 mg (144% DV)
1.6× RDA — within safe limits 196 studies (A:5, B:63)
382 mcg DFE (96% DV)
Exceeds UL by 382.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
120 mcg (5000% DV)
50.0× RDA — above typical dose 139 studies (A:1, B:44)
7 mg (304% DV)
3.0× RDA — within safe limits 9 studies — no high-quality reviews
Sodium
95 mg (4% DV)
Potassium
250 mg (5% DV)
3180 mg
Exceeds UL by 1.1× (UL: 3000 mg) 393 studies (A:18, B:204)
Market median: 1000.0mg (1115 products) 24 studies (A:0, B:9)
Market median: 600.0mg (79 products) 25 studies (A:0, B:6)
150 mg
Market median: 1000.0mg (212 products) 12 studies (A:0, B:3)
Market median: 1000.0mg (2 products)
Market median: 375.0mg (171 products) 31 studies (A:1, B:14)
Stinging Nettle leaf extract
70 mg
Market median: 450.0mg (254 products) 243 studies (A:0, B:100)
Market median: 200.0mg (198 products) 6 studies — no high-quality reviews
BioPerine Complex
6 mg

Other Ingredients

Gelatin Water, Purified Glycerin Soy Lecithin Annatto Maltodextrin Titanium Dioxide Dicalcium Phosphate Beeswax St. John's Bread Soybean Oil Turmeric
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: (Adult) Take six (6) liquid soft-gels per day with a meal and a full glass (8 oz) of water. May be taken all at once or in divided doses.

Warnings & Precautions

Usage warnings: Do not use if safety seal is broken.

Check with your doctor before using the product if you are using medication or have any medical conditions. Do not use if you may become pregnant, are pregnant or nursing.

Do not use if you have a bile duct obstruction. Do not exceed recommended daily intake.

Not intended for use by persons under 18. Keep out of reach or children.

Warning: (State of California Prop 65) This product contains a chemical known to the State of California to cause birth defects or other reproductive harm.

Contains: Crustacean Shellfish (crab, lobster, shrimp), Fish (anchovy, sardine), Soy

Formulation Notes

3-in-1 Joint Formula combines nutrients, oils and botanical extracts to promote joint comfort. This powerful formula is designed to support healthy joints in three distinct ways: Rebuild: The well-known ingredients of Glucosamine and Chondroitin are included in this formula to help rebuild cartilage. These nutrients promote healthy tissues and help to maintain joint structure and mobility. Lubricate: Glucosamine and Chondroitin enhance the lubricating synovial fluid that cushions and supports joints. These nutrients support joint comfort. Soothes: This formula is enhanced by the inclusion of Omega-3 Fatty Acids from Fish Oil and Flaxseed Oil. It also delivers a blend of soothing botanical extracts, including Boswellia, Turmeric and Stinging Nettle.

3-in-1 Joint Formula can help to rebuild, lubricate and soothe your joints. This advanced combination of nutrients can give you the support you need to promote long-term joint and connective tissue health. What makes us different: Liquid Soft-gels - The nutrients in these easy-to-swallow liquid soft-gels are released fast. Other forms of delivery can contain binders and fillers that may cause stomach upset and offer no nutritional value. Advanced Liquid Soft-Gels provide an optimum delivery system.

Quality Assurance - Irwin Naturals is committed to providing the highest quality products for your health. We employ compliance testing to ensure purity and potency.

Patented BioPerine - Our special BioPerine Complex enhances the bioavailability, absorption and potency of many nutrients.

Glucosamine Chondroitin MSM Omega 3 Turmeric

(1) Rebuild (2) Lubricate (3) Soothe

No preservatives added.

Additional Information

Pass Quality Tested Guaranteed

Global responsibility - Over the years we have donated to organizations that support the environment and the health of our children.

Store in a cool, dry place.

Questions: Contact Consumer Affairs 1-800-297-3273 - Weekdays 8:00 am to 5:00 pm (PST) 100+ Highly Specialized Products: www.IrwinNaturals.com

Full disclosure ingredient panel

Metadata

Product Details

UPC / SKU7 10363 26242 6
DSLD Entry Date2023-06-22
Product TypeOther Combinations
FormSoftgel Capsule
DSLD ID292060
Data Updated2026-04-11
Research

Research Evidence

2
Research Sources
42
Avg Quality
2
Rct
C Pharmacokinetic assessment of constituents of Boswellia serrata, pine bark extracts, curcumin in combination including methylsulfonylmethane in healthy volunteers.
Rct The Journal of pharmacy and pharmacology PubMed DOI
C [Comparative efficacy of a combination of undenatured type II collagen, Boswellic acids, methylsulfonylmethane, vitamins C and D3 and a combination of chondroitin sulfate and glucosamine hydrochloride in the treatment of primary osteoarthritis of the knee joint].
Rct Terapevticheskii arkhiv PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.