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Pycnogenol Supreme

product on market Tablet or Pill Source Naturals Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 34% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

This formula combines Vitamin C and botanical extracts from green tea and Polygonum cuspidatum, which are studied for their antioxidant properties. There is moderate evidence supporting these ingredients for reducing oxidative stress and supporting vascular health. However, the overall evidence coverage for this specific profile is limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Pycnogenol Supreme
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Tablet(s)
Serving Size
30
Servings
Other Combinations
Product Type
34%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Calories
10 Calorie(s)
Total Carbohydrates
1 Gram(s) (1% DV)
Vitamin C
500 mg (555% DV)
Polygonum cuspidatum root extract
200 mg
Market median: 260.0mg (249 products) 158 studies (A:4, B:61)
Proanthodyn
150 mg
100 mg
Market median: 450.0mg (254 products) 243 studies (A:0, B:100)
Rosemary leaf extract
100 mg
Lecithin
100 mg
100 mg
Market median: 200.0mg (136 products) 3 studies — no high-quality reviews
100 mg
Market median: 500.0mg (283 products) 174 studies (A:0, B:62)
Market median: 120.0mg (440 products) 191 studies (A:1, B:71)
60 mg
Market median: 500.0mg (19 products)
Pycnogenol
50 mg
50 mg
Market median: 250.0mg (562 products) 55 studies (A:0, B:19)
Market median: 333.0mg (166 products) 9 studies (A:0, B:2)
Market median: 500.0mg (283 products) 174 studies (A:0, B:62)
Market median: 470.0mg (230 products) 9 studies (A:3, B:3)
Cranberry
50 mg
Sweet Cherry Fruit Extract
50 mg
Market median: 500.0mg (138 products) 2 studies — no high-quality reviews
Market median: 500.0mg (115 products)
Lycium fruit extract
40 mg
Strawberry
40 mg
Market median: 600.0mg (200 products) 7 studies (A:0, B:1)
Amla
40 mg
Market median: 250.0mg (182 products) 10 studies (A:0, B:2)
Market median: 175.0mg (497 products) 11 studies (A:0, B:1)
Mangosteen fruit rind extract
10 mg
Raspberry leaf extract
10 mg
Bioperine
6 mg
Market median: 100.0mg (120 products)

Other Ingredients

silicified Microcrystalline Cellulose Stearic Acid modified Cellulose Gum Silica
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested Use: 2 tablets daily.

Warnings & Precautions

Contains soy.

Warning: Do not use if you are pregnant, may become pregnant, breastfeeding, or taking anticoagulant drugs such as heparin or warfarin (Coumadin). May interfere with the absorption of iron; if you are anemic, take between meals. If you are taking any prescription drug, consult a physician before using this product.

Do not use if either tamper-evident seal is broken or missing.

Keep out of the reach of children.

Formulation Notes

Berry & botanical antioxidant complex

PYCNOGENOL SUPREME is a power-packed antioxidant complex featuring Pycnogenol, a premium, scientifically researched pine bark extract. This synergistic formula combines Pycnogenol and a full 500 mg of Vitamin C with more than 25 additional plant-derived antioxidants for the broad range of free radical protection recommended by many scientists. Together these compounds defend your tissues and cells from the oxidative stress that is so prevalent in today's environment.

Additional Information

Store in a cool, dry place.

Metadata

Product Details

UPC / SKU0 21078 02220 6
DSLD Entry Date2023-01-23
Product TypeOther Combinations
FormTablet or Pill
BrandSource Naturals
DSLD ID275384
Data Updated2026-04-11
Research

Research Evidence

371
Research Sources
54
Avg Quality
148
Meta Analysis
82
Systematic Review
71
Rct
62
Clinical Trial
2
Regulatory Source
1
Cochrane Review
1
Narrative Review
1
Other
1
Openfda Safety
A Vitamin C supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Vitamin C supplementation for the primary prevention of cardiovascular disease
Systematic Review The Cochrane database of systematic reviews 2017 PubMed DOI
A Vitamin C for preventing and treating the common cold
Meta Analysis The Cochrane database of systematic reviews 2013 PubMed DOI
A Vitamin C for preventing and treating pneumonia
Meta Analysis The Cochrane database of systematic reviews 2013 PubMed DOI
A Vitamin E supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Vitamin C supplementation for prevention and treatment of pneumonia
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
A Vitamin C supplementation for prevention and treatment of pneumonia
Systematic Review The Cochrane database of systematic reviews 2021 PubMed DOI
A Nutritional interventions for preventing and treating pressure ulcers
Meta Analysis The Cochrane database of systematic reviews 2024 PubMed DOI
A Does Vitamin C Supplementation Provide a Protective Effect in Periodontal Health? A Systematic Review and Meta-Analysis
Meta Analysis International journal of molecular sciences 2024 PubMed DOI
A Circulating vitamin C concentration and risk of cancers: a Mendelian randomization study
Meta Analysis BMC medicine 2021 PubMed DOI
View all evidence for Vitamin C →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.