🟢 94/100

This product looks safe

  • Niacin: 150mg is 4.3× the Tolerable Upper Intake Level (35mg)
  • Folate: 8.3mg is 8.3× the Tolerable Upper Intake Level (1.0mg)
  • 75% of ingredients have research evidence
D Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Niacin: 150mg is 4.3× the Tolerable Upper Intake Level (35mg)
⚠️ Folate: 8.3mg is 8.3× the Tolerable Upper Intake Level (1.0mg)

Label Data

1 Capsule(s) Serving Size
90 Servings
Other Combinations Product Type
75% Evidence Coverage

Supplement Facts — Evidence Check

Vitamin C
15 mg (17% DV)
25 mg (2083% DV)
📊 20.8× RDA — above typical dose 📚 76 studies (Tier A: 0, B: 33)
RDA 1.2mg This product: 25mg
25 mg (1923% DV)
📊 19.2× RDA — above typical dose 📚 12 studies (Tier A: 0, B: 1)
RDA 1.3mg This product: 25mg
150 mg NE (938% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 4.3× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 150mg UL 35mg
55 mg (3235% DV)
📊 42.3× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 55mg UL 100mg
8.3 mg DFE (2075% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 8.3× (UL: 1.0 mg) 📚 225 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 8.3mg UL 1.0mg
1000 mcg (41667% DV)
📊 416.7× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 1.0mg
400 mcg (1333% DV)
📊 13.3× RDA — above typical dose 📚 26 studies (Tier A: 0, B: 11)
RDA 0.03mg This product: 0.4mg
150 mg (3000% DV)
📊 30.0× RDA — above typical dose 📚 1 studies — no high-quality reviews
RDA 5mg This product: 150mg
50 mg (9% DV)
✅ Within RDA (0.1× RDA of 550 mg) 📚 36 studies (Tier A: 1, B: 7)
RDA 550mg This product: 50mg UL 3500mg
50 mg
📊 Market median: 550.0mg (217 products) 📚 29 studies (Tier A: 0, B: 5)
This product: 50mg
50 mg
📊 Market median: 500.0mg (9 products)
This product: 50mg

Other Ingredients

Cellulose

Label Claims — Verification

Nutrient
All Other
All Other (99% of products) Structure/Function (77% of products) Nutrient (60% of products) Approved Health (5% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Directions: Use only as directed by a healthcare professional.

⚠️ Warnings & Precautions

Caution: Consult your healthcare professional before taking this product.

Keep tightly closed in a cool, dry place, out of the reach of children.

Directions: Use only as directed by a healthcare professional.

🧪 Formulation Notes

Egg free Gluten free Free of nuts Dairy free

Manufactured in a GMP Compliant Facility

Professional strength L-Methylfolate

Additional Information

Keep tightly closed in a cool, dry place, out of the reach of children.

Product Details

UPC / SKU 8 38287 00815 6
DSLD Entry Date 2022-11-22
Product Type Other Combinations
Form Capsule
Brand MethylPro
DSLD ID 274831
Data Updated 2026-04-11

Research Evidence

363 Research Sources
57 Avg Quality Score
187 Meta Analysis
56 Systematic Review
54 Rct
29 Guideline
26 Clinical Trial
6 Cochrane Review
2 Regulatory Source
1 Other
1 Openfda Safety
A Homocysteine-lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017
A Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015
A Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies
Meta Analysis Digestive diseases and sciences 2021
A The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis
Meta Analysis Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2021
A A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis Nutrients 2024
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019
A Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials
Meta Analysis Critical reviews in food science and nutrition 2022
A Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants
Meta Analysis Critical reviews in food science and nutrition 2023
A Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care
Meta Analysis The Cochrane database of systematic reviews 2025
View all evidence for Folate →

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