Vol-Plus by Trigen Laboratories — Ingredients, Evidence & Safety

🟢 100/100

This product looks safe

No ingredients exceed tolerable upper intake levels
71% of ingredients have research evidence

A Label Compliance Grade

Product Label

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Label Data

1 Tablet(s) Serving Size

500 Servings

Multi-Vitamin and Mineral (MVM) Product Type

71% Evidence Coverage

Supplement Facts — Evidence Check

Folic Acid

1 mg (250% DV)

✅ 2.5× RDA — within safe limits 📚 225 studies (Tier A: 10, B: 105)

RDA 0.4mg This product: 1mg UL 1.0mg

Vitamin A

4000 IU (80% DV)

Vitamin C

120 mg (200% DV)

Calcium

200 mg (20% DV)

Iron

27 mg (150% DV)

Vitamin D3

400 IU (100% DV)

✅ Within RDA (0.7× RDA of 0.015 mg) 📚 604 studies (Tier A: 16, B: 251)

RDA 0.015mg This product: 0.01mg UL 0.1mg

Vitamin E

22 mg (157% DV)

✅ 1.5× RDA — within safe limits 📚 177 studies (Tier A: 3, B: 90)

RDA 15mg This product: 22mg UL 1000mg

Vitamin B1

1.84 mg (123% DV)

✅ 1.5× RDA — within safe limits 📚 76 studies (Tier A: 0, B: 33)

RDA 1.2mg This product: 1.84mg

Vitamin B2

3 mg (176% DV)

✅ 2.3× RDA — within safe limits 📚 12 studies (Tier A: 0, B: 1)

RDA 1.3mg This product: 3mg

Niacinamide

20 mg (100% DV)

✅ 1.4× RDA — within safe limits 📚 193 studies (Tier A: 5, B: 63)

RDA 14mg This product: 20mg UL 35mg

Vitamin B6

10 mg (500% DV)

📊 7.7× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)

RDA 1.3mg This product: 10mg UL 100mg

Vitamin B12

12 mcg (200% DV)

📊 5.0× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)

RDA 0.0024mg This product: 0.012mg

Zinc

25 mg (167% DV)

✅ 2.3× RDA — within safe limits 📚 258 studies (Tier A: 6, B: 134)

RDA 11mg This product: 25mg UL 40mg

Copper

2 mg (100% DV)

✅ 2.2× RDA — within safe limits 📚 36 studies (Tier A: 0, B: 11)

RDA 0.9mg This product: 2mg UL 10mg

Other Ingredients

Microcrystalline Cellulose Beige Color Coating pregelatinized Starch Croscarmellose Sodium Di Calcium Phosphate Magnesium Stearate Stearic Acid fumed Silica Ascorbyl Palmitate

Label Claims — Verification

❓ All Other

All Other (99% of products) Structure/Function (77% of products) Nutrient (60% of products) Approved Health (5% of products)

Target Groups

Adult (18 - 50 Years)

Product Information

⚠️ Warnings & Precautions

WARNING: Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6. KEEP THIS PRODUCT OUT OF REACH OF CHILDREN. In case of accidental overdose, call a doctor or poison control center immediately.

🧪 Formulation Notes

DESCRIPTION Vol-Plus is an orally administered prescription vitamin for the dietary management of patient with nutritional deficiencies or are in need of nutritional supplementation.

Additional Information

All prescriptions using this product shall be pursuant to state statutes as applicable. This is not an Orange Book product. There are no implied or explicit claims on therapeutic equivalence.

Rev. 04/13

Lot: Exp:

Rx Only

Vol-Plus is an oval, beige tablet with "TL519" debossed on one side.

Peel label for prescribing and product information.

STORAGE Store at room temperature 20(0)-25(0)C (68(0)-77(0)F), excursions permitted to 15(0)-30(0)C (59(0)-86(0)F) [see USP controlled room temperature].

Dispense in a tight, light resistant container as defined by the USP with a child resistant closure.

Protect from light and moisture and avoid excessive heat. Note that contact with moisture may produce surface discoloration of the tablet.

Call your doctor about side effects.

Product Details

UPC / SKU 3 13811 51950 1

DSLD Entry Date 2013-10-25

Product Type Multi-Vitamin and Mineral (MVM)

Form Tablet or Pill

Brand Trigen Laboratories

DSLD ID 26495

Data Updated 2026-04-11

Research Evidence

363 Research Sources

57 Avg Quality Score

187 Meta Analysis

56 Systematic Review

54 Rct

29 Guideline

26 Clinical Trial

6 Cochrane Review

2 Regulatory Source

1 Other

1 Openfda Safety

A Homocysteine-lowering interventions for preventing cardiovascular events

Meta Analysis The Cochrane database of systematic reviews 2017

PubMed DOI

A Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes

Meta Analysis The Cochrane database of systematic reviews 2015

PubMed DOI

A Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies

Meta Analysis Digestive diseases and sciences 2021

PubMed DOI

A The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis

Meta Analysis Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2021

PubMed DOI

A A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Meta Analysis Nutrients 2024

PubMed DOI

A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis

Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025

PubMed DOI

A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies

Meta Analysis Critical reviews in food science and nutrition 2019

PubMed DOI

A Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials

Meta Analysis Critical reviews in food science and nutrition 2022

PubMed DOI

A Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants

Meta Analysis Critical reviews in food science and nutrition 2023

PubMed DOI

A Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care

Meta Analysis The Cochrane database of systematic reviews 2025

PubMed DOI

View all evidence for Folate →