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Folic Acid 400 mcg Supplement

product on market Tablet or Pill Nature Made Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Folic acid is supported by strong evidence for preventing neural tube defects during early fetal development. This ingredient plays a critical role in DNA synthesis and red blood cell formation. Research indicates it is generally safe and effective when used at the recommended dosage.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Folic Acid 400 mcg Supplement
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
Vitamin
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

400 mcg (100% DV)
Within RDA (1.0× RDA) 226 studies (A:10, B:105)

Other Ingredients

Dibasic Calcium Phosphate Croscarmellose Sodium Magnesium Stearate Folic Acid
Claims

Label Claims — Verification

Unverified All Other
Unverified Approved Health
Unverified Structure/Function
Info

Product Information

Directions for Use

SUGGESTED USE: Take one tablet daily with a meal.

Warnings & Precautions

Store in a cool, dry place, out of reach of children.

Do not use if imprinted seal under cap is broken or missing.

Formulation Notes

No Artificial Colors - No Artificial Flavors - No Preservatives No Chemical Solvents, Yeast, Starch or Gluten

Additional Information

Supplement

List No. 1744 L31AA Cat. 348 5A006

Recommended By Pharmacists

DIETARY SUPPLEMENT USP VERIFIED(TM)

ENTER CODE WELLNESS REWARDS CODE VISIT OUR WEBSITE & EARN FREE VITAMINS www.NatureMade.com - 1-800-276-2878

IMPORTANT B VITAMIN FOR WOMEN OF CHILDBEARING AGE - Plays a role in the development of the nervous system of the fetus. Adequate Folic Acid in healthful diets may reduce a woman's risk of having a child with a brain or spinal cord birth defect.

Keep bottle tightly closed.

USP has tested and verified ingredients, product and manufacturing process. USP sets official standards for dietary supplements. See: www.usp-dsvp.org. Valid only for U.S. and Puerto Rico residents. Lot.: Exp.:

Metadata

Product Details

UPC / SKU0 31604 01744 6
DSLD Entry Date2012-06-25
Product TypeVitamin
FormTablet or Pill
BrandNature Made
DSLD ID9191
Data Updated2026-04-11
Research

Research Evidence

363
Research Sources
57
Avg Quality
187
Meta Analysis
56
Systematic Review
54
Rct
29
Guideline
26
Clinical Trial
6
Cochrane Review
2
Regulatory Source
1
Other
1
Openfda Safety
A Homocysteine-lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies
Meta Analysis Digestive diseases and sciences 2021 PubMed DOI
A The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis
Meta Analysis Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2021 PubMed DOI
A A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis Nutrients 2024 PubMed DOI
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials
Meta Analysis Critical reviews in food science and nutrition 2022 PubMed DOI
A Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants
Meta Analysis Critical reviews in food science and nutrition 2023 PubMed DOI
A Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care
Meta Analysis The Cochrane database of systematic reviews 2025 PubMed DOI
View all evidence for Folate →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.