Home/ Supplements/ Folate/ B-Complex + 10 mg 5-MTHF

B-Complex + 10 mg 5-MTHF

product on market Capsule Metabolic Maintenance Safety: 93/100
93/100

This product looks safe

  • Niacin: 150mg is 4.3× the Tolerable Upper Intake Level (35mg)
  • Folate: 10mg is 10.0× the Tolerable Upper Intake Level (1.0mg)
  • 82% of ingredients have research evidence
D Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

This formula contains B vitamins, including 5-MTHF, which are supported by strong evidence for their roles in energy metabolism and neurological function. These ingredients facilitate cellular processes and support cognitive health. The overall profile is associated with a high safety score, indicating a low risk of adverse effects.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Niacin: 150mg is 4.3× the Tolerable Upper Intake Level (35mg)

Folate: 10mg is 10.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for B-Complex + 10 mg 5-MTHF
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
Other Combinations
Product Type
82%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

25 mg (1667% DV)
20.8× RDA — above typical dose 76 studies (A:0, B:33)
25 mg (1471% DV)
19.2× RDA — above typical dose 13 studies (A:0, B:1)
150 mg (750% DV)
Exceeds UL by 4.3× (UL: 35 mg) 196 studies (A:5, B:63)
55 mg (2750% DV)
42.3× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
10 mg (2500% DV)
Exceeds UL by 10.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
1000 mcg (16667% DV)
416.7× RDA — above typical dose 139 studies (A:1, B:44)
400 mcg (133% DV)
13.3× RDA — above typical dose 27 studies (A:0, B:11)
150 mg (1500% DV)
30.0× RDA — above typical dose 2 studies — no high-quality reviews
50 mg
Within RDA (0.1× RDA) 38 studies (A:1, B:7)
50 mg
Market median: 550.0mg (217 products) 29 studies (A:0, B:5)
50 mg
Market median: 500.0mg (9 products) 7 studies — no high-quality reviews

Other Ingredients

vegetarian capsule L-Leucine
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

DIRECTIONS: Use only as directed by a healthcare professional.

Warnings & Precautions

Keep tightly closed in a cool, dry place out of the reach of children.

CAUTION: Consult your healthcare professional before taking this product.

Formulation Notes

High-potency B-Complex with phosphorylated B-2 and B-6, methylated B-12, PLUS 10 mg 5-MTHF.

Gluten and Excipient-free

Additional Information

Keep tightly closed in a cool, dry place out of the reach of children.

Manufactured in a GMP Compliant Facility

535001A EXP 5/14

ESSENTIALS

V.01

Metadata

Product Details

UPC / SKU8 38287 00535 3
DSLD Entry Date2013-08-23
Product TypeOther Combinations
FormCapsule
BrandMetabolic Maintenance
DSLD ID24746
Data Updated2026-04-11
Research

Research Evidence

363
Research Sources
57
Avg Quality
187
Meta Analysis
56
Systematic Review
54
Rct
29
Guideline
26
Clinical Trial
6
Cochrane Review
2
Regulatory Source
1
Other
1
Openfda Safety
A Homocysteine-lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies
Meta Analysis Digestive diseases and sciences 2021 PubMed DOI
A The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis
Meta Analysis Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2021 PubMed DOI
A A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis Nutrients 2024 PubMed DOI
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials
Meta Analysis Critical reviews in food science and nutrition 2022 PubMed DOI
A Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants
Meta Analysis Critical reviews in food science and nutrition 2023 PubMed DOI
A Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care
Meta Analysis The Cochrane database of systematic reviews 2025 PubMed DOI
View all evidence for Folate →
Compare

Similar Products

Bio-Plus Biotin With Folic Acid
Douglas Laboratories · Capsule
100
Folic Acid
OL Olympian Labs · Capsule
100
L-5-MTHF Natural S-Isomer
Designs for Health · Capsule
100
Folic Acid
DaVinci Laboratories Of Vermont · Capsule
100
SAMe with Vitamins B-6, B-12 and 5-MTHF
Designs for Health · Capsule
100
View all Folate products →
Folate research Best Folate All Folate products More from Metabolic Maintenance View on NIH DSLD →

This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.