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B-Complex 50

product on market Softgel Capsule The Vitamin Shoppe Safety: 93/100
93/100

This product looks safe

  • Niacin: 50mg is 1.4× the Tolerable Upper Intake Level (35mg)
  • Folate: 667mg is 667.0× the Tolerable Upper Intake Level (1.0mg)
  • 82% of ingredients have research evidence
D Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

This profile contains essential B vitamins that support energy metabolism and neurological function. There is strong clinical evidence for the roles of thiamine, riboflavin, and folate in cellular health. The combination of these nutrients is generally well-tolerated and associated with a high safety score.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Niacin: 50mg is 1.4× the Tolerable Upper Intake Level (35mg)

Folate: 667mg is 667.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for B-Complex 50
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Softgel(s)
Serving Size
Other Combinations
Product Type
82%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

50 mg (4170% DV)
41.7× RDA — above typical dose 76 studies (A:0, B:33)
50 mg (3850% DV)
38.5× RDA — above typical dose 13 studies (A:0, B:1)
50 mg (310% DV)
Exceeds UL by 1.4× (UL: 35 mg) 196 studies (A:5, B:63)
50 mg (2940% DV)
38.5× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
667 mcg DFE (170% DV)
Exceeds UL by 667.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
50 mcg (2080% DV)
20.8× RDA — above typical dose 139 studies (A:1, B:44)
50 mcg (170% DV)
1.7× RDA — within safe limits 27 studies (A:0, B:11)
50 mg (1000% DV)
10.0× RDA — above typical dose 2 studies — no high-quality reviews
5 mg
Market median: 125.0mg (294 products) 38 studies (A:1, B:7)
50 mg
Market median: 550.0mg (217 products) 29 studies (A:0, B:5)
50 mg
Market median: 500.0mg (9 products) 7 studies — no high-quality reviews

Other Ingredients

Soybean Oil Gelatin Glycerin Polyglycitol Syrup Soy Lecithin purified Water yellow Beeswax Turmeric dispersion Titanium Dioxide Annatto suspension
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: As a dietary supplement, take one (1) softgel daily, preferably with a meal.

Warnings & Precautions

Contains: Soy.

Warning: Consult your healthcare provider prior to use if you are pregnant, nursing, taking any medication or have any medical conditions.

Warning: This product contains niacin, which should be taken with food. If taken on an empty stomach, niacin may cause temporary flushing.

Keep out of reach of children.

Tamper evident Do not use if outer seal is broken or missing.

Formulation Notes

Gluten free Dairy free Nut free

Contains: Soy.

Does Not Contain: Wheat, gluten, sugar, salt, dairy, citrus, fish, preservative or artificial flavors.

Warning: This product contains niacin, which should be taken with food.

Additional Information

Vitamin

Energy production Nutrient metabolism

Actual size

Store in a cool, dry place.

Item No. VS-2047 1318843 ER 29

Metadata

Product Details

UPC / SKU7 66536 02047 8
DSLD Entry Date2017-09-21
Product TypeOther Combinations
FormSoftgel Capsule
BrandThe Vitamin Shoppe
DSLD ID77919
Data Updated2026-04-11
Research

Research Evidence

100
Research Sources
56
Avg Quality
48
Systematic Review
30
Meta Analysis
13
Rct
6
Clinical Trial
1
Cochrane Review
1
Regulatory Source
B Thiamine for prevention and treatment of Wernicke-Korsakoff Syndrome in people who abuse alcohol
Systematic Review The Cochrane database of systematic reviews 2013 PubMed DOI
B Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials
Systematic Review Nutritional neuroscience 2023 PubMed DOI
B Effect of thiamine supplementation on glycaemic outcomes in adults with type 2 diabetes: a systematic review and meta-analysis
Meta Analysis BMJ open 2022 PubMed DOI
B Effect of intravenous thiamine administration on critically ill patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
B Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis
Systematic Review Intensive care medicine 2022 PubMed DOI
B Effect of Combined Diclofenac and B Vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) for Low Back Pain Management: Systematic Review and Meta-analysis
Meta Analysis Pain medicine (Malden, Mass.) 2020 PubMed DOI
B Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis
Meta Analysis Critical care medicine 2021 PubMed DOI
B The effects of thiamine supplementation on patients with heart failure: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Complementary therapies in medicine 2022 PubMed DOI
B Hydrocortisone Combined with Vitamin C and Thiamine in the Treatment of Sepsis/Septic Shock: A Systematic Review with Meta-Analysis and Trial Sequential Analysis
Meta Analysis Clinical and investigative medicine. Medecine clinique et experimentale 2023 PubMed DOI
B Thiamine for Wernicke-Korsakoff Syndrome in people at risk from alcohol abuse
Systematic Review The Cochrane database of systematic reviews 2004 PubMed
View all evidence for Thiamine →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.