Estro Support

product on market Tablet or Pill 21st Century 🟢 Safety: 100/100
Brand: 21st Century
🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 62% of ingredients have research evidence
A Label Compliance Grade

Product Label

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Label Data

1 Tablet(s) Serving Size
Botanical with Nutrients Product Type
62% Evidence Coverage

Supplement Facts — Evidence Check

30 IU (100% DV)
✅ 1.3× RDA — within safe limits 📚 177 studies (Tier A: 3, B: 90)
RDA 15mg This product: 20.1mg UL 1000mg
2 mg (133% DV)
✅ 1.7× RDA — within safe limits 📚 76 studies (Tier A: 0, B: 33)
RDA 1.2mg This product: 2mg
2 mg (118% DV)
✅ 1.5× RDA — within safe limits 📚 12 studies (Tier A: 0, B: 1)
RDA 1.3mg This product: 2mg
20 mg (100% DV)
✅ 1.4× RDA — within safe limits 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 20mg UL 35mg
10 mg (500% DV)
📊 7.7× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 10mg UL 100mg
400 mcg (100% DV)
✅ Within RDA (1.0× RDA of 0.4 mg) 📚 225 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 0.4mg UL 1.0mg
6 mcg (100% DV)
✅ 2.5× RDA — within safe limits 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 0.006mg
Calcium
150 mg (15% DV)
70 mcg (100% DV)
✅ 1.3× RDA — within safe limits 📚 172 studies (Tier A: 0, B: 67)
RDA 0.055mg This product: 0.07mg UL 0.4mg
Blend
150 mg
purified Isoflavones
55 mg
40 mg
📊 Market median: 80.0mg (136 products)
Median 80.0mg This product: 40mg
1.5 mg
📊 Market median: 3.0mg (58 products) 📚 2 studies — no high-quality reviews
This product: 1.5mg UL 20mg

Other Ingredients

Cellulose Croscarmellose Sodium Maltodextrin Silicon Dioxide Stearic Acid Polydextrose Magnesium Stearate Titanium Dioxide Artificial colors PEG

Label Claims — Verification

❓ All Other
❓ Structure/Function
All Other (98% of products) Structure/Function (81% of products) Nutrient (56% of products) Qualified Health (2% of products)

Target Groups

Adult Female (18 - 50 Years)

Product Information

📋 Directions for Use

Directions: As a dietary supplement, take one (1) tablet daily before mealtime or as directed by your healthcare provider. Do not exceed recommended dosage. Individual results may vary.

⚠️ Warnings & Precautions

Warning: Consult a healthcare provider prior to use if: pregnant, nursing, on medications, have a medical condition or are planning a medical procedure.

Stop use and contact a physician if adverse reactions occur.

This product contains a soybean-based ingredient and should not be taken by those with soy or soybean allergies.

Keep out of reach of children.

Do not use if product appears tampered with or seal is broken.

Contains a soy ingredient.

🧪 Formulation Notes

This product contains a soybean-based ingredient and should not be taken by those with soy or soybean allergies.

No added Sugar, Yeast, Preservatives or Artificial Flavors.

Vitamins, minerals and herbs to support the needs of women.*

Contains a soy ingredient.

Additional Information

Store at room temperature.

LABORATORY TESTED GUARANTEED QUALITY

500797-0414

Product Details

UPC / SKU 7 40985 27006 6
DSLD Entry Date 2015-03-25
Product Type Botanical with Nutrients
Form Tablet or Pill
Brand 21st Century
DSLD ID 43816
Data Updated 2026-04-11

Research Evidence

253 Research Sources
55 Avg Quality Score
128 Meta Analysis
52 Systematic Review
41 Rct
24 Clinical Trial
3 Regulatory Source
1 Narrative Review
1 Other
1 Guideline
1 Openfda Safety
A Vitamin E supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2015
PubMed DOI
A Vitamin E for Alzheimer's dementia and mild cognitive impairment
Systematic Review The Cochrane database of systematic reviews 2017
PubMed DOI Cochrane
A Vitamin E for Alzheimer's disease and mild cognitive impairment
Meta Analysis The Cochrane database of systematic reviews 2008
PubMed DOI Cochrane
A Vitamin E for Alzheimer's dementia and mild cognitive impairment
Meta Analysis The Cochrane database of systematic reviews 2012
PubMed DOI Cochrane
A Exercise for intermittent claudication
Meta Analysis The Cochrane database of systematic reviews 2017
PubMed DOI
A Effects of vitamin E supplementation on the risk and progression of AD: a systematic review and meta-analysis
Meta Analysis Nutritional neuroscience 2021
PubMed DOI
A Effect of vitamin E supplementation in rheumatoid arthritis: a systematic review and meta-analysis
Meta Analysis European journal of clinical nutrition 2023
PubMed DOI
A Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT)
Rct JAMA 2011
PubMed DOI
A Vitamin E for Alzheimer's dementia and mild cognitive impairment
Meta Analysis The Cochrane database of systematic reviews 2017
PubMed DOI Cochrane
B Vitamin, Mineral, and Multivitamin Supplementation to Prevent Cardiovascular Disease and Cancer: US Preventive Services Task Force Recommendation Statement.
Guideline JAMA 2022
PubMed DOI
View all evidence for Vitamin E →

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