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B-Replete

product on market Capsule NuMedica Safety: 94/100
94/100

This product looks safe

  • Niacin: 140mg is 4.0× the Tolerable Upper Intake Level (35mg)
  • Folate: 680mg is 680.0× the Tolerable Upper Intake Level (1.0mg)
  • 75% of ingredients have research evidence
D Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · methodology

This formula contains B-complex vitamins and Vitamin C, which are essential for energy metabolism and cellular function. Strong clinical evidence supports the role of these nutrients in maintaining neurological health and systemic homeostasis. However, overall evidence coverage for this specific combination is limited.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Niacin: 140mg is 4.0× the Tolerable Upper Intake Level (35mg)

Folate: 680mg is 680.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for B-Replete
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
180
Servings
Other Combinations
Product Type
75%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Vitamin C
30 mg (33% DV)
20 mg (1667% DV)
16.7× RDA — above typical dose 76 studies (A:0, B:33)
20 mg (1538% DV)
15.4× RDA — above typical dose 13 studies (A:0, B:1)
140 mg (875% DV)
Exceeds UL by 4.0× (UL: 35 mg) 196 studies (A:5, B:63)
25 mg (1471% DV)
19.2× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
680 mcg DFE (170% DV)
Exceeds UL by 680.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
800 mcg (33333% DV)
333.3× RDA — above typical dose 139 studies (A:1, B:44)
400 mg (1333% DV)
13333.3× RDA — above typical dose 27 studies (A:0, B:11)
150 mg (3000% DV)
30.0× RDA — above typical dose 2 studies — no high-quality reviews
30 mg (5% DV)
Within RDA (0.1× RDA) 38 studies (A:1, B:7)
20 mg
16.7× RDA — above typical dose 76 studies (A:0, B:33)
Market median: 500.0mg (9 products) 7 studies — no high-quality reviews

Other Ingredients

Ascorbyl Palmitate Hydroxypropyl Methylcellulose Microcrystalline Cellulose L-Leucine Bamboo Silica Silicon Dioxide
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: Take one capsule 1-2 times per day or as directed by your healthcare practitioner.

Warnings & Precautions

Caution: Keep out of reach of children.

Formulation Notes

B-Replete is an advanced B-complex providing the entire spectrum of B-vitamins and other complementary nutrients to support healthy homocysteine metabolism, adrenal, energy and neurological function as well as healthy stress response. B-Replete provides activated forms of Vitamins B2, B6, and B12, with the addition of benfotiamine, a fat soluble and physiologically active form of thiamin. The 5-MTHF in this formula - Quatrefolic - is the most biologically active form of folate, allowing rapid uptake into the bloodstream. The 5-MTHF in this formula is also known as the "L" form of 5-MTHF since it is the reduced form of folate. The addition of para-aminobenzoic acid (PABA), Vitamin C and therapeutic doses of B12 and B5 make this a powerful and comprehensive activated B-complex that stands out above the rest.

This formula meets or exceeds cGMP Quality Standards.

Does not contain: Milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, soy.

Rapid Uptake 5-MTHF Biologically active folate Activated B-Vitamins

Professional quality formulas Support for healthy adrenal, neurological and stress response

B-Replete featuring 5-MTHF as Quatrefolic

GF Gluten-free

Vegetarian

Additional Information

Storage: Keep tightly closed in a cool, dry place.

Metadata

Product Details

UPC / SKU8 12527 01236 3
DSLD Entry Date2025-01-23
Product TypeOther Combinations
FormCapsule
DSLD ID323495
Data Updated2026-04-11
Research

Research Evidence

371
Research Sources
54
Avg Quality
148
Meta Analysis
82
Systematic Review
71
Rct
62
Clinical Trial
2
Regulatory Source
1
Cochrane Review
1
Narrative Review
1
Other
1
Openfda Safety
A Vitamin C supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Vitamin C supplementation for the primary prevention of cardiovascular disease
Systematic Review The Cochrane database of systematic reviews 2017 PubMed DOI
A Vitamin C for preventing and treating the common cold
Meta Analysis The Cochrane database of systematic reviews 2013 PubMed DOI
A Vitamin C for preventing and treating pneumonia
Meta Analysis The Cochrane database of systematic reviews 2013 PubMed DOI
A Vitamin E supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Vitamin C supplementation for prevention and treatment of pneumonia
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
A Vitamin C supplementation for prevention and treatment of pneumonia
Systematic Review The Cochrane database of systematic reviews 2021 PubMed DOI
A Nutritional interventions for preventing and treating pressure ulcers
Meta Analysis The Cochrane database of systematic reviews 2024 PubMed DOI
A Does Vitamin C Supplementation Provide a Protective Effect in Periodontal Health? A Systematic Review and Meta-Analysis
Meta Analysis International journal of molecular sciences 2024 PubMed DOI
A Circulating vitamin C concentration and risk of cancers: a Mendelian randomization study
Meta Analysis BMC medicine 2021 PubMed DOI
View all evidence for Vitamin C →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.