🟢 94/100

This product looks safe

  • Niacin: 140mg is 4.0× the Tolerable Upper Intake Level (35mg)
  • Folate: 680mg is 680.0× the Tolerable Upper Intake Level (1.0mg)
  • 75% of ingredients have research evidence
D Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Niacin: 140mg is 4.0× the Tolerable Upper Intake Level (35mg)
⚠️ Folate: 680mg is 680.0× the Tolerable Upper Intake Level (1.0mg)

Label Data

1 Capsule(s) Serving Size
180 Servings
Other Combinations Product Type
75% Evidence Coverage

Supplement Facts — Evidence Check

Vitamin C
30 mg (33% DV)
20 mg (1667% DV)
📊 16.7× RDA — above typical dose 📚 76 studies (Tier A: 0, B: 33)
RDA 1.2mg This product: 20mg
20 mg (1538% DV)
📊 15.4× RDA — above typical dose 📚 12 studies (Tier A: 0, B: 1)
RDA 1.3mg This product: 20mg
140 mg (875% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 4.0× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 140mg UL 35mg
25 mg (1471% DV)
📊 19.2× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 25mg UL 100mg
680 mcg DFE (170% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 680.0× (UL: 1.0 mg) 📚 225 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 680mg UL 1.0mg
800 mcg (33333% DV)
📊 333.3× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 0.8mg
400 mg (1333% DV)
📊 13333.3× RDA — above typical dose 📚 26 studies (Tier A: 0, B: 11)
RDA 0.03mg This product: 400mg
150 mg (3000% DV)
📊 30.0× RDA — above typical dose 📚 1 studies — no high-quality reviews
RDA 5mg This product: 150mg
30 mg (5% DV)
✅ Within RDA (0.1× RDA of 550 mg) 📚 36 studies (Tier A: 1, B: 7)
RDA 550mg This product: 30mg UL 3500mg
20 mg
📊 16.7× RDA — above typical dose 📚 76 studies (Tier A: 0, B: 33)
RDA 1.2mg This product: 20mg
📊 Market median: 500.0mg (9 products)
This product: 15mg

Other Ingredients

Ascorbyl Palmitate Hydroxypropyl Methylcellulose Microcrystalline Cellulose L-Leucine Bamboo Silica Silicon Dioxide

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (99% of products) Structure/Function (83% of products) Nutrient (54% of products)

Target Groups

Vegetarian Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

Directions: Take one capsule 1-2 times per day or as directed by your healthcare practitioner.

⚠️ Warnings & Precautions

Caution: Keep out of reach of children.

🧪 Formulation Notes

B-Replete is an advanced B-complex providing the entire spectrum of B-vitamins and other complementary nutrients to support healthy homocysteine metabolism, adrenal, energy and neurological function as well as healthy stress response. B-Replete provides activated forms of Vitamins B2, B6, and B12, with the addition of benfotiamine, a fat soluble and physiologically active form of thiamin. The 5-MTHF in this formula - Quatrefolic - is the most biologically active form of folate, allowing rapid uptake into the bloodstream. The 5-MTHF in this formula is also known as the "L" form of 5-MTHF since it is the reduced form of folate. The addition of para-aminobenzoic acid (PABA), Vitamin C and therapeutic doses of B12 and B5 make this a powerful and comprehensive activated B-complex that stands out above the rest.

This formula meets or exceeds cGMP Quality Standards.

Does not contain: Milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, soy.

Rapid Uptake 5-MTHF Biologically active folate Activated B-Vitamins

Professional quality formulas Support for healthy adrenal, neurological and stress response

B-Replete featuring 5-MTHF as Quatrefolic

GF Gluten-free

Vegetarian

Additional Information

Storage: Keep tightly closed in a cool, dry place.

Product Details

UPC / SKU 8 12527 01236 3
DSLD Entry Date 2025-01-23
Product Type Other Combinations
Form Capsule
Brand NuMedica
DSLD ID 323495
Data Updated 2026-04-11

Research Evidence

371 Research Sources
54 Avg Quality Score
148 Meta Analysis
82 Systematic Review
71 Rct
62 Clinical Trial
2 Regulatory Source
1 Cochrane Review
1 Narrative Review
1 Other
1 Openfda Safety
A Vitamin C supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2015
A Vitamin C supplementation for the primary prevention of cardiovascular disease
Systematic Review The Cochrane database of systematic reviews 2017
A Vitamin C for preventing and treating the common cold
Meta Analysis The Cochrane database of systematic reviews 2013
A Vitamin C for preventing and treating pneumonia
Meta Analysis The Cochrane database of systematic reviews 2013
A Vitamin E supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2015
A Vitamin C supplementation for prevention and treatment of pneumonia
Meta Analysis The Cochrane database of systematic reviews 2020
A Vitamin C supplementation for prevention and treatment of pneumonia
Systematic Review The Cochrane database of systematic reviews 2021
A Nutritional interventions for preventing and treating pressure ulcers
Meta Analysis The Cochrane database of systematic reviews 2024
A Does Vitamin C Supplementation Provide a Protective Effect in Periodontal Health? A Systematic Review and Meta-Analysis
Meta Analysis International journal of molecular sciences 2024
A Circulating vitamin C concentration and risk of cancers: a Mendelian randomization study
Meta Analysis BMC medicine 2021
View all evidence for Vitamin C →

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