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St. Johns-Dep

product on market Tablet or Pill Nutri-West Safety: 98/100
98/100

This product looks safe

  • Niacinamide: 50mg is 1.4× the Tolerable Upper Intake Level (35mg)
  • 53% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

St. John's Wort has moderate evidence for supporting mood, while B vitamins and folic acid are essential for neurological function. Calcium supports general cellular health. The overall evidence coverage for this specific combination is limited.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Niacinamide: 50mg is 1.4× the Tolerable Upper Intake Level (35mg)

Label

Product Label

Label for St. Johns-Dep
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
Botanical with Nutrients
Product Type
53%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Market median: 300.0mg (240 products) 20 studies — no high-quality reviews
100 mcg (166% DV)
Within RDA (0.2× RDA) 226 studies (A:10, B:105)
10 mg (666% DV)
8.3× RDA — above typical dose 76 studies (A:0, B:33)
250 mcg (416% DV)
104.2× RDA — above typical dose 139 studies (A:1, B:44)
Calcium
20 mg (2% DV)
16 mg (4% DV)
Market median: 500.0mg (1 products) 316 studies (A:8, B:159)
3.8× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
3.8× RDA — above typical dose 13 studies (A:0, B:1)
50 mg
Exceeds UL by 1.4× (UL: 35 mg) 196 studies (A:5, B:63)
Hyssop
15 mg
Damiana
25 mg
Blue Vervain
25 mg
Gingko Extract
5 mg
Market median: 120.0mg (440 products) 191 studies (A:1, B:71)
Eleuthero
10 mg
Claims

Label Claims — Verification

Unverified All Other
Info

Product Information

Directions for Use

Directions for use: One tablet with meals or as directed.

Warnings & Precautions

DO NOT TAKE WITH ANY ANTIDEPRESSANT

TAMPER RESISTANT OUTER SEAL - DO NOT USE IF BROKEN.

NOTICE: Do not use this product while taking any prescription drugs, without the advice of your prescribing physician.

Avoid excessive exposure to UV irradiation (e.g. sunlight, tanning) when using this product.

KEEP OUT OF REACH OF CHILDREN.

Formulation Notes

Contains no starch, salt, sugar, corn, yeast, soy, milk, or preservatives.

Additional Information

7899 MFG03/2009

"When You Want The Best"

FOR DISTRIBUTION BY HEALTH CARE PROFESSIONALS ONLY

Store in cool, dry place.

Product #1717

Metadata

Product Details

DSLD Entry Date2013-12-24
Product TypeBotanical with Nutrients
FormTablet or Pill
BrandNutri-West
DSLD ID28266
Data Updated2026-04-11
Research

Research Evidence

43
Research Sources
48
Avg Quality
16
Meta Analysis
14
Systematic Review
7
Rct
4
Regulatory Source
1
Clinical Trial
1
Openfda Safety
B St John's wort for major depression
Systematic Review The Cochrane database of systematic reviews 2008 PubMed DOI
B Clinical use of Hypericum perforatum (St John's wort) in depression: A meta-analysis
Meta Analysis Journal of affective disorders 2017 PubMed DOI
B A systematic review of St. John's wort for major depressive disorder
Meta Analysis Systematic reviews 2016 PubMed DOI
B St John's wort for depression
Systematic Review The Cochrane database of systematic reviews 2000 PubMed
B Efficacy of Pharmacological Interventions in Milder Depression: A Systematic Review and Meta-Analysis
Meta Analysis Neuropsychopharmacology reports 2025 PubMed DOI
B St John's wort for depression
Meta Analysis The Cochrane database of systematic reviews 2005 PubMed
C St John's wort for depression: meta-analysis of randomised controlled trials
Meta Analysis The British journal of psychiatry : the journal of mental science 2005 PubMed
C The effect of Hypericum perforatum on postmenopausal symptoms and depression: A randomized controlled trial
Rct Complementary therapies in medicine 2019 PubMed DOI
C Hypericum extract versus imipramine or placebo in patients with moderate depression: randomised multicentre study of treatment for eight weeks
Rct BMJ (Clinical research ed.) 1999 PubMed
C Hypericum perforatum as a cognitive enhancer in rodents: A meta-analysis
Meta Analysis Scientific reports 2016 PubMed DOI
View all evidence for St Johns Wort →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.