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Best St Johns Wort Supplements (2026)

Ranked by safety score and evidence coverage from 0 independent research sources

280
Products Analyzed
0
Research Sources
99
Avg Safety Score
17%
Evidence-Backed

What the Research Says

✨ AI-generated · Qwen 3.6 · methodology

St. John's Wort (Hypericum perforatum) is a herbal supplement widely used for the treatment of depressive disorders. Extensive research, including multiple Cochrane reviews and meta-analyses, suggests it is more effective than placebo and comparable to standard antidepressants for mild-to-moderate depression.

Major Depressive Disorder (Mild-to-Moderate): strong Menopausal Symptoms/Depression: moderate Cognitive Enhancement: weak

AI-generated summary. See methodology.

Rankings

Top-Ranked St Johns Wort Products

Ranked by safety score (0–100), then evidence coverage.

1
St. John's Wort With B Vitamins And Folic Acid
HBC Protocols · Tablet or Pill
100 80%
2
Mood Aid With 5-HTP & St. John's Wort
Nature's Way · Capsule
100 75%
3
St. John's Wort Plus 300 mg Standardized Extract with Ginsen...
Martin Avenue Pharmacy · Capsule
100 66%
4
Mood Health Support With St. John's Wort & Kava
Martin Avenue Pharmacy · Capsule
100 66%
5
St. John's Wort
DC · Capsule
100 66%
6
St. John's Wort
Wonder Laboratories · Capsule
100 66%
7
Mood Boost
Signature Supplements · Capsule
100 62%
8
Hypericum Perforatum III St. John's Wort Extract
HBC Protocols · Tablet or Pill
100 60%
9
NeuroZac
Sun Ten · Capsule
100 50%
10
Hypericum Perforatum II
HBC Protocols · Capsule
100 50%
11
St. John's Wort
Nature's Sunshine · Capsule
100 50%
12
New Mood
Progressive Professional from Progressive Laboratories · Capsule
100 50%
13
Neurapas Balance
Pascoe · Tablet or Pill
100 50%
14
Neurapas Balance
Pascoe · Tablet or Pill
100 50%
15
Mood Formula
Vita Logic · Capsule
100 44%
16
Joy-Filled
Happy Healthy Hippie · Capsule
100 42%
17
Calm On
The Healthy Hamster · Capsule
100 42%
18
Happy Formula 1300 mg
Wholesome Wellness · Capsule
100 42%
19
Unwind
Friendly Vitamins · Capsule
100 42%
20
Mood Support
Vitabase · Capsule
100 40%

Showing top 20 of 280 products. View all products →

How We Rank

Products are ranked by safety score (0–100), which considers UL exceedance, unsupported health claims, and proprietary blend disclosure. Products with equal safety scores are then sorted by evidence coverage — the percentage of ingredients backed by Tier-A or Tier-B research.

Safety scores are computed from product label data (DSLD) cross-referenced with 0 research sources. See our Editorial Policy for full methodology.