Best St Johns Wort Supplements (2026)

Ranked by safety score and evidence coverage from 0 independent research sources

280 Products Analyzed

0 Research Sources

99 Avg Safety Score

17% Evidence-Backed

What the Research Says

St. John's Wort is a herbal supplement primarily researched for its efficacy in treating depressive disorders. Extensive meta-analyses and systematic reviews indicate it is effective for mild-to-moderate depression, often with results comparable to standard antidepressants.

Major/Mild-to-Moderate Depression: strong Postmenopausal Symptoms: moderate Anxiety and Mood Disorders: moderate Dental Pain: insufficient

AI-generated summary based on 0 research sources. See methodology.

Top-Ranked St Johns Wort Products

Products ranked by safety score (0–100), then evidence coverage. Higher is better.

#	Product	Safety	Evidence	Form
1	St. John's Wort With B Vitamins And Folic Acid HBC Protocols	100	80%	Tablet or Pill
2	Mood Aid With 5-HTP & St. John's Wort Nature's Way	100	75%	Capsule
3	St. John's Wort Plus 300 mg Standardized Extract with Ginsen... Martin Avenue Pharmacy	100	66%	Capsule
4	Mood Health Support With St. John's Wort & Kava Martin Avenue Pharmacy	100	66%	Capsule
5	St. John's Wort DC	100	66%	Capsule
6	St. John's Wort Wonder Laboratories	100	66%	Capsule
7	Mood Boost Signature Supplements	100	62%	Capsule
8	Hypericum Perforatum III St. John's Wort Extract HBC Protocols	100	60%	Tablet or Pill
9	NeuroZac Sun Ten	100	50%	Capsule
10	Hypericum Perforatum II HBC Protocols	100	50%	Capsule
11	St. John's Wort Nature's Sunshine	100	50%	Capsule
12	New Mood Progressive Professional from Progressive Laboratories	100	50%	Capsule
13	Neurapas Balance Pascoe	100	50%	Tablet or Pill
14	Neurapas Balance Pascoe	100	50%	Tablet or Pill
15	Mood Formula Vita Logic	100	44%	Capsule
16	Joy-Filled Happy Healthy Hippie	100	42%	Capsule
17	Calm On The Healthy Hamster	100	42%	Capsule
18	Happy Formula 1300 mg Wholesome Wellness	100	42%	Capsule
19	Unwind Friendly Vitamins	100	42%	Capsule
20	Mood Support Vitabase	100	40%	Capsule

Showing top 20 of 280 products. View all products →

How We Rank

Products are ranked by safety score (0–100), which considers UL exceedance, unsupported health claims, and proprietary blend disclosure. Products with equal safety scores are then sorted by evidence coverage — the percentage of ingredients backed by Tier-A or Tier-B research.

Safety scores are computed from product label data (DSLD) cross-referenced with 0 research sources. See our Editorial Policy for full methodology.