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St. John's Wort

product on market Capsule Nature's Sunshine Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 50% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

St. John's Wort and passionflower are researched for their potential to support mood and relaxation. Evidence for St. John's Wort in managing mild-to-moderate depression is considered strong, while evidence for passionflower is more limited. These ingredients are generally well-tolerated, though they may interact with certain medications.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for St. John's Wort
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
100
Servings
Botanical
Product Type
50%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Market median: 300.0mg (240 products) 20 studies — no high-quality reviews
100 mg
Market median: 250.0mg (60 products) 7 studies (A:0, B:1)

Other Ingredients

Capsule Cellulose Magnesium Stearate Silicon Dioxide
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Recommended Use: Take 1 capsule with a meal three times daily.

Warnings & Precautions

Warning: Do not use St. John's Worth while taking any prescription drugs without the advice of your prescribing physician. Do not use with prescription antidepressants, contraceptives, immunosuppressants, anticoagulants, Digoxin, blood thinners, or medications for HIV, epilepsy, or cancer.

Avoid excessive exposure to UV radiation (e.g. sunlight, tanning).

Not recommended for use by pregnant or lactating women.

Keep out of the reach of children.

Do not use if inner seal is missing or damaged.

Formulation Notes

Supports emotional balance and feelings of well-being Helps maintain positive outlook and healthy motivation

St. John's Wort helps support a person's emotional state and manage the stresses of everyday life.

Ko Pareve (Kosher)

Natural mood support Concentrated Supports emotional balance & well-being Guaranteed pure

Additional Information

Bottle made from 100% post consumer recycled material. We are committed to you and our planet. Scan to learn more.

Ko Pareve (Kosher)

New look! Same great product

Herbal experts since 1972

Metadata

Product Details

UPC / SKU0 99904 00655 3
DSLD Entry Date2021-09-24
Product TypeBotanical
FormCapsule
BrandNature's Sunshine
DSLD ID255489
Data Updated2026-04-11
Research

Research Evidence

43
Research Sources
48
Avg Quality
16
Meta Analysis
14
Systematic Review
7
Rct
4
Regulatory Source
1
Clinical Trial
1
Openfda Safety
B St John's wort for major depression
Systematic Review The Cochrane database of systematic reviews 2008 PubMed DOI
B Clinical use of Hypericum perforatum (St John's wort) in depression: A meta-analysis
Meta Analysis Journal of affective disorders 2017 PubMed DOI
B A systematic review of St. John's wort for major depressive disorder
Meta Analysis Systematic reviews 2016 PubMed DOI
B St John's wort for depression
Systematic Review The Cochrane database of systematic reviews 2000 PubMed
B Efficacy of Pharmacological Interventions in Milder Depression: A Systematic Review and Meta-Analysis
Meta Analysis Neuropsychopharmacology reports 2025 PubMed DOI
B St John's wort for depression
Meta Analysis The Cochrane database of systematic reviews 2005 PubMed
C St John's wort for depression: meta-analysis of randomised controlled trials
Meta Analysis The British journal of psychiatry : the journal of mental science 2005 PubMed
C The effect of Hypericum perforatum on postmenopausal symptoms and depression: A randomized controlled trial
Rct Complementary therapies in medicine 2019 PubMed DOI
C Hypericum extract versus imipramine or placebo in patients with moderate depression: randomised multicentre study of treatment for eight weeks
Rct BMJ (Clinical research ed.) 1999 PubMed
C Hypericum perforatum as a cognitive enhancer in rodents: A meta-analysis
Meta Analysis Scientific reports 2016 PubMed DOI
View all evidence for St Johns Wort →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.