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Hypericum Perforatum II

product on market Capsule HBC Protocols Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 50% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · methodology

St. John's Wort is supported by strong evidence for managing mild-to-moderate depression, while grape seed extract is researched for its antioxidant properties. Overall evidence coverage for this specific formulation is very limited. The profile maintains a high safety score.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Hypericum Perforatum II
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
Botanical
Product Type
50%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Market median: 300.0mg (240 products) 20 studies — no high-quality reviews
Market median: 100.0mg (284 products) 10 studies (A:0, B:4)

Other Ingredients

Maltodextrin Silica Stearic Acid Magnesium Stearate
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions For Use: Adults: As a dietary supplement, take one capsule three times daily.

Warnings & Precautions

Keep out of the reach of children.

Not to be used by people taking MAO inhibitors.

May cause hypersensitivity to sunlight.

Not to be taken by pregnant woman. Talk to your doctor if you are on prescription medication.

Formulation Notes

St. John's Wort extract

Standardized to contain 0.3% hypericin, minimum 3% hyperforin

Formulated with the super-antioxidant grape seed extract to protect and ensure hyperforin stability.

No animal products are used in this product. Contains no sugar, starch, yeast, artificial colors, preservatives or dairy products.

Additional Information

300 mg

Promotes a balanced emotional outlook

Research grade extract

National Institutes of Health tested and approved.

Metadata

Product Details

UPC / SKU6 79840 47280 5
DSLD Entry Date2017-06-23
Product TypeBotanical
FormCapsule
DSLD ID74961
Data Updated2026-04-11
Research

Research Evidence

43
Research Sources
48
Avg Quality
16
Meta Analysis
14
Systematic Review
7
Rct
4
Regulatory Source
1
Clinical Trial
1
Openfda Safety
B St John's wort for major depression
Systematic Review The Cochrane database of systematic reviews 2008 PubMed DOI
B Clinical use of Hypericum perforatum (St John's wort) in depression: A meta-analysis
Meta Analysis Journal of affective disorders 2017 PubMed DOI
B A systematic review of St. John's wort for major depressive disorder
Meta Analysis Systematic reviews 2016 PubMed DOI
B St John's wort for depression
Systematic Review The Cochrane database of systematic reviews 2000 PubMed
B Efficacy of Pharmacological Interventions in Milder Depression: A Systematic Review and Meta-Analysis
Meta Analysis Neuropsychopharmacology reports 2025 PubMed DOI
B St John's wort for depression
Meta Analysis The Cochrane database of systematic reviews 2005 PubMed
C St John's wort for depression: meta-analysis of randomised controlled trials
Meta Analysis The British journal of psychiatry : the journal of mental science 2005 PubMed
C The effect of Hypericum perforatum on postmenopausal symptoms and depression: A randomized controlled trial
Rct Complementary therapies in medicine 2019 PubMed DOI
C Hypericum extract versus imipramine or placebo in patients with moderate depression: randomised multicentre study of treatment for eight weeks
Rct BMJ (Clinical research ed.) 1999 PubMed
C Hypericum perforatum as a cognitive enhancer in rodents: A meta-analysis
Meta Analysis Scientific reports 2016 PubMed DOI
View all evidence for St Johns Wort →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.