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Hypericum Perforatum III St. John's Wort Extract

product on market Tablet or Pill HBC Protocols Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 60% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

St. John's Wort and B-complex vitamins are supported by moderate to strong evidence for mood support and neurological function. Leucoselect provides antioxidant properties, though evidence for its specific efficacy in this blend is limited. The overall ingredient profile is associated with a high safety score.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Hypericum Perforatum III St. John's Wort Extract
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
30
Servings
Botanical with Nutrients
Product Type
60%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

15 mg (750% DV)
11.5× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
300 mcg (75% DV)
Within RDA (0.7× RDA) 226 studies (A:10, B:105)
100 mcg (1667% DV)
41.7× RDA — above typical dose 139 studies (A:1, B:44)
Market median: 300.0mg (240 products) 20 studies — no high-quality reviews
Leucoselect(TM)
1.22 mg

Other Ingredients

Dibasic Calcium Phosphate Microcrystalline Cellulose Vegetable oil Croscarmelose Sodium Magnesium Stearate Silicon Dioxide
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions for Use: Adults-as a dietary supplement, take one tablet three times daily.

Warnings & Precautions

Keep out of the reach of children.

Not to be used by people taking MAO inhibitors.

May cause sensitivity to sunlight.

Not to be taken by pregnant women. Talk to your doctor if you are on prescription medication.

Formulation Notes

Standardized to contain 0.3% hypericin, minimum 5% hyperforin

No animal products are used in this product. Contains no sugar, starch, yeast, artificial colors, preservatives or dairy products.

Formulated with Vitamin B6, B12, Folic Acid, and the broad spectrum grape seed antioxidant Leucoselect.

Additional Information

Vitamin B6 is essential for the body's production of serotonin. Folic acid may help relieve anxiety and panic associated with depression and should always be taken in combination with vitamin B12 as taking only one of these B vitamins can mask a deficiency in the other. B12 has been show to support the augmentation of SAMe. Leucoselect protects and ensures hyperforin stability.

Promotes a Balanced Emotional Outlook

Research grade

National Institutes of Health tested and approved.

Metadata

Product Details

DSLD Entry Date2012-07-25
Product TypeBotanical with Nutrients
FormTablet or Pill
BrandHBC Protocols
DSLD ID11357
Data Updated2026-04-11
Research

Research Evidence

43
Research Sources
48
Avg Quality
16
Meta Analysis
14
Systematic Review
7
Rct
4
Regulatory Source
1
Clinical Trial
1
Openfda Safety
B St John's wort for major depression
Systematic Review The Cochrane database of systematic reviews 2008 PubMed DOI
B Clinical use of Hypericum perforatum (St John's wort) in depression: A meta-analysis
Meta Analysis Journal of affective disorders 2017 PubMed DOI
B A systematic review of St. John's wort for major depressive disorder
Meta Analysis Systematic reviews 2016 PubMed DOI
B St John's wort for depression
Systematic Review The Cochrane database of systematic reviews 2000 PubMed
B Efficacy of Pharmacological Interventions in Milder Depression: A Systematic Review and Meta-Analysis
Meta Analysis Neuropsychopharmacology reports 2025 PubMed DOI
B St John's wort for depression
Meta Analysis The Cochrane database of systematic reviews 2005 PubMed
C St John's wort for depression: meta-analysis of randomised controlled trials
Meta Analysis The British journal of psychiatry : the journal of mental science 2005 PubMed
C The effect of Hypericum perforatum on postmenopausal symptoms and depression: A randomized controlled trial
Rct Complementary therapies in medicine 2019 PubMed DOI
C Hypericum extract versus imipramine or placebo in patients with moderate depression: randomised multicentre study of treatment for eight weeks
Rct BMJ (Clinical research ed.) 1999 PubMed
C Hypericum perforatum as a cognitive enhancer in rodents: A meta-analysis
Meta Analysis Scientific reports 2016 PubMed DOI
View all evidence for St Johns Wort →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.