Hypericum Perforatum III St. John's Wort Extract

product on market Tablet or Pill HBC Protocols 🟢 Safety: 100/100
Brand: HBC Protocols
🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 60% of ingredients have research evidence
A Label Compliance Grade

Product Label

📄 Open Full PDF View on NIH DSLD →
📸

Have a supplement label? Find it here.

Upload a photo of any supplement label to search our database of 92,312 products.

Label Data

1 Tablet(s) Serving Size
30 Servings
Botanical with Nutrients Product Type
60% Evidence Coverage

Supplement Facts — Evidence Check

15 mg (750% DV)
📊 11.5× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 15mg UL 100mg
300 mcg (75% DV)
✅ Within RDA (0.7× RDA of 0.4 mg) 📚 225 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 0.3mg UL 1.0mg
100 mcg (1667% DV)
📊 41.7× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 0.1mg
300 mg
📊 Market median: 300.0mg (240 products) 📚 11 studies — no high-quality reviews
This product: 300mg
Leucoselect(TM)
1.22 mg

Other Ingredients

Dibasic Calcium Phosphate Microcrystalline Cellulose Vegetable oil Croscarmelose Sodium Magnesium Stearate Silicon Dioxide

Label Claims — Verification

❓ Nutrient
❓ All Other
❓ Structure/Function
All Other (99% of products) Structure/Function (78% of products) Nutrient (2% of products)

Target Groups

Vegan Vegetarian Adult (18 - 50 Years) Dairy Free Sugar Free

Product Information

📋 Directions for Use

Directions for Use: Adults-as a dietary supplement, take one tablet three times daily.

⚠️ Warnings & Precautions

Keep out of the reach of children.

Not to be used by people taking MAO inhibitors.

May cause sensitivity to sunlight.

Not to be taken by pregnant women. Talk to your doctor if you are on prescription medication.

🧪 Formulation Notes

Standardized to contain 0.3% hypericin, minimum 5% hyperforin

No animal products are used in this product. Contains no sugar, starch, yeast, artificial colors, preservatives or dairy products.

Formulated with Vitamin B6, B12, Folic Acid, and the broad spectrum grape seed antioxidant Leucoselect.

Additional Information

Vitamin B6 is essential for the body's production of serotonin. Folic acid may help relieve anxiety and panic associated with depression and should always be taken in combination with vitamin B12 as taking only one of these B vitamins can mask a deficiency in the other. B12 has been show to support the augmentation of SAMe. Leucoselect protects and ensures hyperforin stability.

Promotes a Balanced Emotional Outlook

Research grade

National Institutes of Health tested and approved.

Product Details

DSLD Entry Date 2012-07-25
Product Type Botanical with Nutrients
Form Tablet or Pill
Brand HBC Protocols
DSLD ID 11357
Data Updated 2026-04-11

Research Evidence

43 Research Sources
48 Avg Quality Score
16 Meta Analysis
14 Systematic Review
7 Rct
4 Regulatory Source
1 Clinical Trial
1 Openfda Safety
B St John's wort for major depression
Systematic Review The Cochrane database of systematic reviews 2008
PubMed DOI
B Clinical use of Hypericum perforatum (St John's wort) in depression: A meta-analysis
Meta Analysis Journal of affective disorders 2017
PubMed DOI
B A systematic review of St. John's wort for major depressive disorder
Meta Analysis Systematic reviews 2016
PubMed DOI
B St John's wort for depression
Systematic Review The Cochrane database of systematic reviews 2000
PubMed
B Efficacy of Pharmacological Interventions in Milder Depression: A Systematic Review and Meta-Analysis
Meta Analysis Neuropsychopharmacology reports 2025
PubMed DOI
B St John's wort for depression
Meta Analysis The Cochrane database of systematic reviews 2005
PubMed
C St John's wort for depression: meta-analysis of randomised controlled trials
Meta Analysis The British journal of psychiatry : the journal of mental science 2005
PubMed
C The effect of Hypericum perforatum on postmenopausal symptoms and depression: A randomized controlled trial
Rct Complementary therapies in medicine 2019
PubMed DOI
C Hypericum extract versus imipramine or placebo in patients with moderate depression: randomised multicentre study of treatment for eight weeks
Rct BMJ (Clinical research ed.) 1999
PubMed
C Hypericum perforatum as a cognitive enhancer in rodents: A meta-analysis
Meta Analysis Scientific reports 2016
PubMed DOI
View all evidence for St Johns Wort →

Compare Similar Products

St. John's Wort With B Vitamins And Folic Acid
St. John's Wort With B Vitamins And Folic Acid HBC Protocols 100
Neurapas Balance
Neurapas Balance Pascoe 100
Neurapas Balance
Neurapas Balance Pascoe 100
Hypericum Perforatum II St. John's Wort Extract HBC Protocols 100
A.Vogel St. John's Wort Tablets Bioforce 100
View all St Johns Wort products →
St Johns Wort research & evidence Best St Johns Wort rankings All St Johns Wort products More from HBC Protocols View on NIH DSLD →