EstroFactors by Metagenics — Ingredients, Evidence & Safety

🟢 100/100

This product looks safe

No ingredients exceed tolerable upper intake levels
62% of ingredients have research evidence

A Label Compliance Grade

Product Label

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Label Data

3 Tablet(s) Serving Size

60 Servings

Other Combinations Product Type

62% Evidence Coverage

Supplement Facts — Evidence Check

Vitamin A

2500 IU (50% DV)

Vitamin D

200 IU (50% DV)

✅ Within RDA (0.3× RDA of 0.015 mg) 📚 604 studies (Tier A: 16, B: 251)

RDA 0.015mg This product: 0.005mg UL 0.1mg

Vitamin E

200 IU (667% DV)

📊 8.9× RDA — above typical dose (UL: 1000 mg) 📚 177 studies (Tier A: 3, B: 90)

RDA 15mg This product: 134.0mg UL 1000mg

Vitamin K

40 mcg (50% DV)

✅ Within RDA (0.3× RDA of 0.12 mg) 📚 273 studies (Tier A: 9, B: 175)

RDA 0.12mg This product: 0.04mg

Vitamin B6

50 mg (2500% DV)

📊 38.5× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)

RDA 1.3mg This product: 50mg UL 100mg

Folate

800 mcg (200% DV)

✅ 2.0× RDA — within safe limits 📚 225 studies (Tier A: 10, B: 105)

RDA 0.4mg This product: 0.8mg UL 1.0mg

Vitamin B12

30 mcg (500% DV)

📊 12.5× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)

RDA 0.0024mg This product: 0.03mg

Isoflavones

100 mg

Turmeric Rhizome Extract

210 mg

📊 Market median: 450.0mg (254 products) 📚 240 studies (Tier A: 0, B: 100)

This product: 210mg

Rosemary Leaf Extract

200 mg

Resveratrol

2 mg

📊 Market median: 167.0mg (311 products) 📚 182 studies (Tier A: 0, B: 65)

This product: 2mg

Trimethylglycine

200 mg

📊 Market median: 496.0mg (192 products) 📚 20 studies — no high-quality reviews

This product: 200mg

Chrysin

90 mg

Other Ingredients

Stearic Acid Microcrystalline Cellulose Calcium Silicate Croscarmellose Sodium Silica Magnesium Stearate Coating

Label Claims — Verification

❓ Nutrient

❓ All Other

❓ Structure/Function

All Other (99% of products) Structure/Function (76% of products) Nutrient (58% of products)

Target Groups

Adult Female (18 - 50 Years) Menopause Gluten Free Dairy Free

Product Information

📋 Directions for Use

DIRECTIONS: Take three tablets daily with a meal or as directed by your healthcare practitioner.

⚠️ Warnings & Precautions

CAUTION: Not recommended for pregnant or nursing women. The effectiveness of oral contraceptives for birth control cannot be ensured while taking this product. If taking medication, consult your healthcare practitioner before use.

Keep out of the reach of children.

WARNING: Excess vitamin A intake may be toxic and may increase the risk of birth defects. Pregnant women and women who may become pregnant should not exceed 5000 IU of preformed vitamin A (retinyl palmitate) per day.

🧪 Formulation Notes

Formulated to Exclude: Wheat, gluten, soy protein, dairy products, nuts, tree nuts, fish, crustacean shellfish, artificial colors, artificial sweeteners, and preservatives.

Additional Information

This unique formula features natural selective estrogen receptor modulators (SERMs) and L-5-methyl tetrahydrofolate to support multiple aspects of estrogen metabolism.

Genetic Potential Through Nutrition

METABOTANICA(R) METHOD

Promotes Estrogen Balance, Reduces Menopausal Symptoms

STORAGE: Keep tightly closed in a cool, dry place.

LL5014G2 0310130 05/12 PROD ESTRE AC 180

Product Details

UPC / SKU 7 55571 91025 7

DSLD Entry Date 2013-10-25

Product Type Other Combinations

Form Tablet or Pill

Brand Metagenics

DSLD ID 26822

Data Updated 2026-04-11

Research Evidence

337 Research Sources

54 Avg Quality Score

161 Meta Analysis

68 Systematic Review

51 Rct

48 Clinical Trial

2 Other

2 Regulatory Source

1 Narrative Review

1 Cochrane Review

1 Guideline

1 Openfda Safety

A Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age

Meta Analysis The Cochrane database of systematic reviews 2017

PubMed DOI Cochrane

A Vitamin A supplementation for the prevention of morbidity and mortality in infants six months of age or less

Meta Analysis The Cochrane database of systematic reviews 2011

PubMed DOI Cochrane

A Vitamin A supplementation for reducing the risk of mother-to-child transmission of HIV infection

Meta Analysis The Cochrane database of systematic reviews 2011

PubMed DOI Cochrane

A Vitamin A supplements for preventing mortality, illness, and blindness in children aged under 5: systematic review and meta-analysis

Meta Analysis BMJ (Clinical research ed.) 2011

PubMed DOI

A Fortification of staple foods with vitamin A for vitamin A deficiency

Systematic Review The Cochrane database of systematic reviews 2019

PubMed DOI Cochrane

A Vitamin A supplementation for the prevention of morbidity and mortality in infants one to six months of age

Narrative Review The Cochrane database of systematic reviews 2016

PubMed DOI Cochrane

A Vitamin A and fish oils for preventing the progression of retinitis pigmentosa

Meta Analysis The Cochrane database of systematic reviews 2020

PubMed DOI

A Exercise training-induced changes in exerkine concentrations may be relevant to the metabolic control of type 2 diabetes mellitus patients: A systematic review and meta-analysis of randomized controlled trials

Meta Analysis Journal of sport and health science 2023

PubMed DOI

A Food fortification with multiple micronutrients: impact on health outcomes in general population

Meta Analysis The Cochrane database of systematic reviews 2019

PubMed DOI

A Oral vitamin A supplements to prevent acute upper respiratory tract infections in children up to seven years of age

Meta Analysis The Cochrane database of systematic reviews 2024

PubMed DOI

View all evidence for Vitamin A →