PreNatal with Folic Acid by 21st Century — Ingredients, Evidence & Safety

🟢 97/100

This product looks safe

Folate: 1334mg is 1334.0× the Tolerable Upper Intake Level (1.0mg)
69% of ingredients have research evidence

C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Folate: 1334mg is 1334.0× the Tolerable Upper Intake Level (1.0mg)

Label Data

1 Tablet(s) Serving Size

60 Servings

Multi-Vitamin and Mineral (MVM) Product Type

69% Evidence Coverage

Supplement Facts — Evidence Check

Vitamin A

1200 mcg (92% DV)

Vitamin C

120 mg (100% DV)

Vitamin D3

10 mcg (67% DV)

✅ Within RDA (0.7× RDA of 0.015 mg) 📚 604 studies (Tier A: 16, B: 251)

RDA 0.015mg This product: 0.01mg UL 0.1mg

Vitamin E

13.5 mg (71% DV)

✅ Within RDA (0.9× RDA of 15 mg) 📚 177 studies (Tier A: 3, B: 90)

RDA 15mg This product: 13.5mg UL 1000mg

Thiamine

1.8 mg (129% DV)

✅ 1.5× RDA — within safe limits 📚 76 studies (Tier A: 0, B: 33)

RDA 1.2mg This product: 1.8mg

Riboflavin

1.7 mg (106% DV)

✅ 1.3× RDA — within safe limits 📚 12 studies (Tier A: 0, B: 1)

RDA 1.3mg This product: 1.7mg

Niacin

20 mg (111% DV)

✅ 1.4× RDA — within safe limits 📚 193 studies (Tier A: 5, B: 63)

RDA 14mg This product: 20mg UL 35mg

Vitamin B6

2.6 mg (130% DV)

✅ 2.0× RDA — within safe limits 📚 113 studies (Tier A: 3, B: 35)

RDA 1.3mg This product: 2.6mg UL 100mg

Folate

1334 mcg DFE (222% DV)

⚠️ Exceeds Tolerable Upper Intake Level by 1334.0× (UL: 1.0 mg) 📚 225 studies (Tier A: 10, B: 105)

RDA 0.4mg This product: 1334mg UL 1.0mg

Vitamin B12

8 mcg (286% DV)

📊 3.3× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)

RDA 0.0024mg This product: 0.008mg

Calcium

200 mg (15% DV)

Iron

28 mg (104% DV)

Zinc

25 mg (192% DV)

✅ 2.3× RDA — within safe limits 📚 258 studies (Tier A: 6, B: 134)

RDA 11mg This product: 25mg UL 40mg

Other Ingredients

Cellulose Starch Stearic Acid Maltodextrin Gelatin Artificial Colors Croscarmellose Sodium Magnesium Silicate Magnesium Stearate PEG Polyvinyl alcohol Silicon Dioxide Titanium Dioxide

Label Claims — Verification

❓ Nutrient

❓ All Other

All Other (99% of products) Structure/Function (77% of products) Nutrient (60% of products) Approved Health (5% of products)

Target Groups

Pregnant Women Adult Female (18 - 50 Years) Lactating Gluten Free

Product Information

📋 Directions for Use

Directions: As a dietary supplement, adults take one (1) tablet daily with any meal, or as directed by your healthcare provider. Do not exceed recommended dosage.

⚠️ Warnings & Precautions

Do not exceed recommended dosage.

Warning: Consult a healthcare provider prior to use if pregnant, nursing, on medications, have a medical condition or are planning a medical procedure.

Stop use and contact a physician if adverse reactions occur.

Keep out of reach of children.

Do not use if product appears to be tampered with or seal is broken.

Warning: Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6. Keep this product out of reach of children. In case of accidental overdose, call a doctor or Poison Control Center immediately.

🧪 Formulation Notes

Gluten free

Before, During & After Pregnancy

No added Yeast.

Additional Information

Compare vs. Stuart PreNatal

Individual results may vary.

Store at room temperature.

Guaranteed quality Laboratory tested

Product Details

UPC / SKU 7 40985 27310 4

DSLD Entry Date 2022-01-22

Product Type Multi-Vitamin and Mineral (MVM)

Form Tablet or Pill

Brand 21st Century

DSLD ID 258549

Data Updated 2026-04-11

Research Evidence

363 Research Sources

57 Avg Quality Score

187 Meta Analysis

56 Systematic Review

54 Rct

29 Guideline

26 Clinical Trial

6 Cochrane Review

2 Regulatory Source

1 Other

1 Openfda Safety

A Homocysteine-lowering interventions for preventing cardiovascular events

Meta Analysis The Cochrane database of systematic reviews 2017

PubMed DOI

A Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes

Meta Analysis The Cochrane database of systematic reviews 2015

PubMed DOI

A Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies

Meta Analysis Digestive diseases and sciences 2021

PubMed DOI

A The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis

Meta Analysis Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2021

PubMed DOI

A A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Meta Analysis Nutrients 2024

PubMed DOI

A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis

Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025

PubMed DOI

A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies

Meta Analysis Critical reviews in food science and nutrition 2019

PubMed DOI

A Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials

Meta Analysis Critical reviews in food science and nutrition 2022

PubMed DOI

A Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants

Meta Analysis Critical reviews in food science and nutrition 2023

PubMed DOI

A Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care

Meta Analysis The Cochrane database of systematic reviews 2025

PubMed DOI

View all evidence for Folate →