🟢 85/100

This product is generally safe

  • Niacin: 40mg is 1.1× the Tolerable Upper Intake Level (35mg)
  • Folate: 400mg is 400.0× the Tolerable Upper Intake Level (1.0mg)
  • Contains proprietary blend — exact ingredient amounts not disclosed
  • 71% of ingredients have research evidence
D Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Niacin: 40mg is 1.1× the Tolerable Upper Intake Level (35mg)
⚠️ Folate: 400mg is 400.0× the Tolerable Upper Intake Level (1.0mg)
ℹ️ Contains proprietary blend — exact ingredient amounts not disclosed

Label Data

3 Heart-Shaped Tablet(s) Serving Size
30 Servings
Other Combinations Product Type
71% Evidence Coverage

Supplement Facts — Evidence Check

40 mg NE (250% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 1.1× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 40mg UL 35mg
4 mg (235% DV)
📊 3.1× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 4mg UL 100mg
400 mcg DFE (100% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 400.0× (UL: 1.0 mg) 📚 225 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 400mg UL 1.0mg
20 mcg (833% DV)
📊 8.3× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 0.02mg
Calcium
50 mg (4% DV)
25 mg (6% DV)
📊 Market median: 4002.0mg (1 products) 📚 20 studies (Tier A: 0, B: 2)
This product: 25mg
70 mcg (127% DV)
✅ 1.3× RDA — within safe limits 📚 172 studies (Tier A: 0, B: 67)
RDA 0.055mg This product: 0.07mg UL 0.4mg
Potassium
99 mg (2% DV)
CardioAid Plant Sterols standardized extract
400 mg
Proprietary Heart Health Botanical Complex
200 mg
75 mg
📊 Market median: 500.0mg (180 products) 📚 5 studies (Tier A: 0, B: 1)
This product: 75mg
75 mg
📊 Market median: 500.0mg (861 products) 📚 60 studies (Tier A: 4, B: 13)
This product: 75mg
25 mg
📊 Market median: 167.0mg (311 products) 📚 182 studies (Tier A: 0, B: 65)
This product: 25mg
10 mg
📊 Market median: 100.0mg (283 products) 📚 142 studies (Tier A: 1, B: 64)
This product: 10mg UL 1200mg

Other Ingredients

Microcrystalline Cellulose Potassium Chloride Calcium Carbonate Vegetable Cellulose Magnesium Oxide Stearic Acid Magnesium Stearate Silica Pharmaceutical Glaze

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (97% of products) Structure/Function (86% of products) Nutrient (36% of products)

Target Groups

Vegetarian Adult (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Directions: As a dietary supplement for adults, three tablets once daily.

⚠️ Warnings & Precautions

Keep out of reach of children.

🧪 Formulation Notes

Cardiovascular support Nutritionally supports every aspect of cardiovascular wellness

Nutritional support for a healthy heart

Gluten Free

Vegetarian

Contains no milk, egg, fish, crustacean shellfish, tree nuts, wheat, peanuts or soy allergen. Contains no artificial colors or preservatives.

Additional Information

Keep tightly closed in a cool, dry place.

Product Details

UPC / SKU 0 97467 47421 5
DSLD Entry Date 2021-05-22
Product Type Other Combinations
Form Tablet or Pill
Brand NaturesPlus
DSLD ID 249811
Data Updated 2026-04-11

Research Evidence

241 Research Sources
55 Avg Quality Score
113 Meta Analysis
75 Systematic Review
32 Rct
11 Clinical Trial
3 Other
3 Regulatory Source
1 Cochrane Review
1 Narrative Review
1 Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016
View all evidence for Niacin →

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