🟢 95/100

This product looks safe

  • Niacin: 50mg is 1.4× the Tolerable Upper Intake Level (35mg)
  • Folate: 1333mg is 1333.0× the Tolerable Upper Intake Level (1.0mg)
  • 67% of ingredients have research evidence
D Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Niacin: 50mg is 1.4× the Tolerable Upper Intake Level (35mg)
⚠️ Folate: 1333mg is 1333.0× the Tolerable Upper Intake Level (1.0mg)

Label Data

2 Tablet(s) Serving Size
15 Servings
Other Combinations Product Type
67% Evidence Coverage

Supplement Facts — Evidence Check

50 mg (4170% DV)
📊 41.7× RDA — above typical dose 📚 76 studies (Tier A: 0, B: 33)
RDA 1.2mg This product: 50mg
50 mg (3850% DV)
📊 38.5× RDA — above typical dose 📚 12 studies (Tier A: 0, B: 1)
RDA 1.3mg This product: 50mg
50 mg NE (310% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 1.4× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 50mg UL 35mg
50 mg (2940% DV)
📊 38.5× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 50mg UL 100mg
1333 mcg DFE (330% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 1333.0× (UL: 1.0 mg) 📚 225 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 1333mg UL 1.0mg
250 mcg (10420% DV)
📊 104.2× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 0.25mg
Calcium
122 mg (10% DV)
200 mg (360% DV)
📊 Market median: 4002.0mg (1 products) 📚 20 studies (Tier A: 0, B: 2)
This product: 200mg
200 mcg (360% DV)
📊 3.6× RDA — above typical dose (UL: 0.4 mg) 📚 172 studies (Tier A: 0, B: 67)
RDA 0.055mg This product: 0.2mg UL 0.4mg
📊 Market median: 250.0mg (562 products) 📚 53 studies (Tier A: 0, B: 19)
This product: 400mg
300 mg
📊 Market median: 450.0mg (254 products) 📚 240 studies (Tier A: 0, B: 100)
This product: 300mg
N-Acetyl-L-Cysteine
300 mg
150 mg
📊 Market median: 420.0mg (227 products)
Median 420.0mg This product: 150mg
150 mg
📊 Market median: 500.0mg (193 products) 📚 7 studies — no high-quality reviews
This product: 150mg
📊 Market median: 200.0mg (198 products) 📚 6 studies — no high-quality reviews
This product: 50mg

Other Ingredients

Microcrystalline Cellulose Stearic Acid Croscarmellose Sodium Vegetable Magnesium Stearate Silicon Dioxide Hydroxypropyl Methylcellulose Glyceryl Triacetate Titanium Dioxide FD&C Yellow #6 FD&C Red #40 FD&C Blue #1 Acacia Gum

Label Claims — Verification

All Other
Structure/Function
All Other (99% of products) Structure/Function (83% of products) Nutrient (47% of products)

Target Groups

Adult (18 - 50 Years)

Product Information

📋 Directions for Use

Directions: Adults - Take two tablets daily, preferably with food, as a dietary supplement.

⚠️ Warnings & Precautions

Caution: If you are pregnant, nursing, taking any medications or have any medical condition, consult your physician before use.

Discontinue use and consult your physician if any adverse reactions occur.

Keep out of reach of children.

Tamper-Evident Seal: Do not use product if seal appears tampered.

🧪 Formulation Notes

May Support a healthy liver function

Guaranteed no added: Sugar, yeast, soy, wheat, dairy, fish, tree nuts, peanuts, egg, fragrance, artificial flavors, preservatives, animal products, crustacean shellfish. Sodium free.

Manufactured in the USA for: Mason Vitamins, Inc.

Soy free

Additional Information

Mason guarantee Laboratory Tested cGMP Certified Good Manufacturing Practice

N Mason Natural Est. 1967

Store in a dry place under controlled room temperature: 20 degrees - 25 degrees C (68 degrees - 77 degrees F).

Please recycle

Product Details

UPC / SKU 3 11845 13568 1
DSLD Entry Date 2021-03-25
Product Type Other Combinations
Form Tablet or Pill
DSLD ID 244692
Data Updated 2026-04-11

Research Evidence

100 Research Sources
56 Avg Quality Score
48 Systematic Review
30 Meta Analysis
13 Rct
6 Clinical Trial
1 Cochrane Review
1 Regulatory Source
B Thiamine for prevention and treatment of Wernicke-Korsakoff Syndrome in people who abuse alcohol
Systematic Review The Cochrane database of systematic reviews 2013
B Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials
Systematic Review Nutritional neuroscience 2023
B Effect of thiamine supplementation on glycaemic outcomes in adults with type 2 diabetes: a systematic review and meta-analysis
Meta Analysis BMJ open 2022
B Effect of intravenous thiamine administration on critically ill patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024
B Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis
Systematic Review Intensive care medicine 2022
B Effect of Combined Diclofenac and B Vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) for Low Back Pain Management: Systematic Review and Meta-analysis
Meta Analysis Pain medicine (Malden, Mass.) 2020
B Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis
Meta Analysis Critical care medicine 2021
B The effects of thiamine supplementation on patients with heart failure: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Complementary therapies in medicine 2022
B Hydrocortisone Combined with Vitamin C and Thiamine in the Treatment of Sepsis/Septic Shock: A Systematic Review with Meta-Analysis and Trial Sequential Analysis
Meta Analysis Clinical and investigative medicine. Medecine clinique et experimentale 2023
B Thiamine for Wernicke-Korsakoff Syndrome in people at risk from alcohol abuse
Systematic Review The Cochrane database of systematic reviews 2004
View all evidence for Thiamine →

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