🟢 95/100

This product looks safe

  • Niacin: 40mg is 1.1× the Tolerable Upper Intake Level (35mg)
  • Folate: 200mg is 200.0× the Tolerable Upper Intake Level (1.0mg)
  • Vanadium: 2.5mg is 1.4× the Tolerable Upper Intake Level (1.8mg)
  • 46% of ingredients have research evidence
F Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Niacin: 40mg is 1.1× the Tolerable Upper Intake Level (35mg)
⚠️ Folate: 200mg is 200.0× the Tolerable Upper Intake Level (1.0mg)
⚠️ Vanadium: 2.5mg is 1.4× the Tolerable Upper Intake Level (1.8mg)

Label Data

46 Gram(s) Serving Size
14 Servings
Other Combinations Product Type
46% Evidence Coverage

Supplement Facts — Evidence Check

Calories
160 Calorie(s)
Total Fat
5 Gram(s) (6% DV)
Total Carbohydrates
15 Gram(s) (5% DV)
Protein
21 Gram(s)
40 mg (250% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 1.1× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 40mg UL 35mg
5 mg (294% DV)
📊 3.8× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 5mg UL 100mg
200 mcg DFE (50% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 200.0× (UL: 1.0 mg) 📚 225 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 200mg UL 1.0mg
50 mcg (2083% DV)
📊 20.8× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 0.05mg
5000 mcg (16667% DV)
📊 166.7× RDA — above typical dose 📚 26 studies (Tier A: 0, B: 11)
RDA 0.03mg This product: 5.0mg
35 mg (700% DV)
📊 7.0× RDA — above typical dose 📚 1 studies — no high-quality reviews
RDA 5mg This product: 35mg
Calcium
25 mg (2% DV)
Iron
4 mg (22% DV)
15 mg (136% DV)
✅ 1.4× RDA — within safe limits 📚 258 studies (Tier A: 6, B: 134)
RDA 11mg This product: 15mg UL 40mg
500 mcg (1429% DV)
📊 14.3× RDA — above typical dose 📚 197 studies (Tier A: 1, B: 55)
RDA 0.035mg This product: 0.5mg
Sodium
430 mg (19% DV)
Potassium
410 mg (9% DV)
InSea Brown Seaweed Blend
500 mg
CinSulin Cinnamon 10:1 aqueous extract
200 mg
📊 Market median: 260.0mg (249 products) 📚 156 studies (Tier A: 4, B: 61)
This product: 200mg
📊 Market median: 200.0mg (198 products) 📚 6 studies — no high-quality reviews
This product: 200mg
50 mg
📊 41.7× RDA — above typical dose 📚 76 studies (Tier A: 0, B: 33)
RDA 1.2mg This product: 50mg
2.5 mg
⚠️ Exceeds Tolerable Upper Intake Level by 1.4× (UL: 1.8 mg) 📚 1 studies (Tier A: 0, B: 1)
This product: 2.5mg UL 1.8mg

Other Ingredients

VegaPro Inulin Natural flavors Sunflower Oil Cellulose Gum Xanthan Gum Medium-Chain Triglyceride Oil Aminogen Fungal Proteases Guar Gum Monk Fruit extract

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (97% of products) Structure/Function (86% of products) Nutrient (36% of products)

Target Groups

Children 4 or More Years of Age Vegan Vegetarian Adult (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Directions: Blend, shake, or briskly stir two level scoops (46 g) into 8-10 oz chilled water and consume one to two times daily; or take one to two scoops approximately 20-30 minutes before each main meal; or use as directed by your healthcare practitioner.

⚠️ Warnings & Precautions

Consult your healthcare practitioner prior to use.

Not intended for use by pregnant or lactating women or children under 12.

Not intended for use by pregnant or lactating women or children under 12. Individuals taking medication should discuss potential interactions with their healthcare practitioner.

Do not use if tamper seal is damaged. The labeling on this product does not comply with California's Proposition 65. Therefore, this product may not be sold in California.

Storage: Keep closed in a cool, dry place out of reach of children.

🧪 Formulation Notes

OptiMetaboliX is an exclusive combination of well-researched, clinically validated, and highly bioavailable ingredients that provides multimodal support for healthy insulin and glucose metabolism and related pathways. It features InSea - an optimized blend of purified polyphenols from wild-crafted brown seaweed. InSea uniquely slows carbohydrate digestion and assimilation and can reduce the impact of high-glycemic foods.

This newly developed, next generation dual carb controller is 100% natural, has an excellent safety profile, and is friendly to the gastrointestinal tract.

OptiMetaboliX also delivers other innovative ingredients, including VegaPro - a proprietary sugar-free, sweetener-free, low-allergy-potential source of vegetable protein from pea protein and rice protein and - CinSulin, a patented water extract of cinnamon with a potent 10:1 yield ratio. Cinnamon has been studied extensively for its roles in supporting healthy glucose uptake, glycogen synthesis, and insulin action, along with maintaining blood lipids already within the normal range. These principal ingredients are complemented by the inclusion of benfotiamine to boost transketolase activity; alpha-lipoic acid; green tea leaf extract; vanadium, chromium, and zinc as Albion TRAACS chelates; 5-MTHF (bioactive folate) as Quatrefolic; fiber from inulin; and other key vitamins and minerals. To avoid the use of added sugar and the aftertaste of stevia, OptiMetaboliX is sweetened with monk fruit.

Does not contain: Wheat, gluten, yeast, soy protein, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, artificial colors, artificial sweeteners, or artificial preservatives.

VegaPro 100% Vegan

100% Gluten-free

No Added Sugar, No Stevia

Additional Information

Professional use only Not for resale on third-party websites, including, including, but not limited to, Amazon and eBay.

Storage: Keep closed in a cool, dry place out of reach of children.

ePV

Typical amino acid profile per serving: Alanine 1,060 mg Arginine 2,140 mg Aspartic Acid 2,820 mg Cysteine 250 mg Glutamic Acid 4,130 mg Glycine 1,1516 mg Histidine 610 mg Isoleucine 1,110 mg Leucine 2,070 mg Lysine 1,760 mg Methionine 270 mg Phenylalanine 1,350 mg Proline 1,110 mg Serine 1,300 mg Taurine 500 mg Threonine 960 mg Tryptophan 250 mg Tyrosine 940 mg Valine 1,230 mg

Third-Party GMP Compliant Verified

This package is completely recyclable

Product Details

UPC / SKU 8 71149 00447 7
DSLD Entry Date 2020-12-26
Product Type Other Combinations
Form Powder
Brand XYMOGEN
DSLD ID 240517
Data Updated 2026-04-11

Research Evidence

241 Research Sources
55 Avg Quality Score
113 Meta Analysis
75 Systematic Review
32 Rct
11 Clinical Trial
3 Other
3 Regulatory Source
1 Cochrane Review
1 Narrative Review
1 Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016
View all evidence for Niacin →

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