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Signature Series Healthy Heart

product on market Capsule The Wellness Company Safety: 97/100
97/100

This product looks safe

  • Folate: 340mg is 340.0× the Tolerable Upper Intake Level (1.0mg)
  • 82% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

This formula contains B vitamins, including folate and B6, which are supported by strong evidence for maintaining homocysteine levels to support cardiovascular health. These nutrients play essential roles in energy metabolism and cellular function. The overall evidence coverage for this specific combination is limited.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folate: 340mg is 340.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for Signature Series Healthy Heart
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Capsule(s)
Serving Size
60
Servings
Other Combinations
Product Type
82%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

2.5 mg (208% DV)
2.1× RDA — within safe limits 76 studies (A:0, B:33)
2.5 mg (192% DV)
1.9× RDA — within safe limits 13 studies (A:0, B:1)
3 mg (176% DV)
2.3× RDA — within safe limits 114 studies (A:3, B:35)
340 mcg DFE (85% DV)
Exceeds UL by 340.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
100 mcg (333% DV)
3.3× RDA — above typical dose 27 studies (A:0, B:11)
2.5 mg (50% DV)
Within RDA (0.5× RDA) 2 studies — no high-quality reviews
50 mcg (91% DV)
Within RDA (0.9× RDA) 173 studies (A:0, B:67)
D-Ribose
500 mg
350 mg
Market median: 500.0mg (180 products) 5 studies (A:0, B:1)
Market median: 500.0mg (861 products) 61 studies (A:4, B:13)
Market median: 100.0mg (283 products) 144 studies (A:1, B:64)

Other Ingredients

Hypromellose Silicon Dioxide Tricalcium Phosphate Stearic Acid Microcrystalline Cellulose
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested use: As a dietary supplement, take two (2) capsules daily with 8-12 oz of water or as directed by a healthcare professional.

Warnings & Precautions

Warning: Intended for use by adults 18 years of age and over. Keep out of reach of children.

Do not use if the seal under cap is broken or missing. Please consult your healthcare practitioner before taking and when using this supplement.

Allergen warning: This product was produced in a facility that may also process ingredients containing milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, and soybeans.

Formulation Notes

Our formulation is designed to support cardiovascular performance, circulation, and muscle mass for a healthy heart. This supplement was formulated by The Wellness Company's doctors as part of a naturalistic approach to health and wellness.

Gluten free Non GMO

Vegan

Cardiovascular & muscular strength

Additional Information

Healthy Heart by the Chief Medical Board

Learn more about our natural products and virtual care at www.TWC.health.

Vegan Made in the USA with ingredients from around the world

Designed & approved by the chief medical board

Metadata

Product Details

UPC / SKU8 50045 40514 4
DSLD Entry Date2025-05-21
Product TypeOther Combinations
FormCapsule
BrandThe Wellness Company
DSLD ID336267
Data Updated2026-04-11
Research

Research Evidence

100
Research Sources
56
Avg Quality
48
Systematic Review
30
Meta Analysis
13
Rct
6
Clinical Trial
1
Cochrane Review
1
Regulatory Source
B Thiamine for prevention and treatment of Wernicke-Korsakoff Syndrome in people who abuse alcohol
Systematic Review The Cochrane database of systematic reviews 2013 PubMed DOI
B Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials
Systematic Review Nutritional neuroscience 2023 PubMed DOI
B Effect of thiamine supplementation on glycaemic outcomes in adults with type 2 diabetes: a systematic review and meta-analysis
Meta Analysis BMJ open 2022 PubMed DOI
B Effect of intravenous thiamine administration on critically ill patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
B Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis
Systematic Review Intensive care medicine 2022 PubMed DOI
B Effect of Combined Diclofenac and B Vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) for Low Back Pain Management: Systematic Review and Meta-analysis
Meta Analysis Pain medicine (Malden, Mass.) 2020 PubMed DOI
B Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis
Meta Analysis Critical care medicine 2021 PubMed DOI
B The effects of thiamine supplementation on patients with heart failure: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Complementary therapies in medicine 2022 PubMed DOI
B Hydrocortisone Combined with Vitamin C and Thiamine in the Treatment of Sepsis/Septic Shock: A Systematic Review with Meta-Analysis and Trial Sequential Analysis
Meta Analysis Clinical and investigative medicine. Medecine clinique et experimentale 2023 PubMed DOI
B Thiamine for Wernicke-Korsakoff Syndrome in people at risk from alcohol abuse
Systematic Review The Cochrane database of systematic reviews 2004 PubMed
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.