MasterMind by Zahler — Ingredients, Evidence & Safety

Product Label

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Safety Alerts

⚠️ Niacin: 70mg is 2.0× the Tolerable Upper Intake Level (35mg)

Label Data

4 Tablet(s) Serving Size

30 Servings

Other Combinations Product Type

86% Evidence Coverage

Supplement Facts — Evidence Check

SAMe

500 mg

📊 Market median: 200.0mg (52 products) 📚 10 studies (Tier A: 0, B: 6)

This product: 500mg

5-HTP

200 mg

📊 Market median: 100.0mg (116 products) 📚 15 studies (Tier A: 0, B: 3)

This product: 200mg

L-Tryptophan

1400 mg

📊 Market median: 500.0mg (70 products)

Median 500.0mg This product: 1400mg

Niacin

70 mg (350% DV)

⚠️ Exceeds Tolerable Upper Intake Level by 2.0× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)

RDA 14mg This product: 70mg UL 35mg

Vitamin B6

70 mg (3500% DV)

📊 53.8× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)

RDA 1.3mg This product: 70mg UL 100mg

Folic Acid

990 mcg (250% DV)

✅ 2.5× RDA — within safe limits 📚 225 studies (Tier A: 10, B: 105)

RDA 0.4mg This product: 0.99mg UL 1.0mg

Vitamin B12

1600 mcg (26670% DV)

📊 666.7× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)

RDA 0.0024mg This product: 1.6mg

Other Ingredients

Stearic Acid Dicalcium Phosphate Microcrystalline Cellulose Magnesium Stearate Croscarmellose Sodium Silicon Dioxide Glyceryl Triacetate Hydroxypropyl Methyl Cellulose Pthalate Ethanol Water Titanium Dioxide

Label Claims — Verification

❓ All Other

❓ Structure/Function

All Other (100% of products) Structure/Function (83% of products) Nutrient (6% of products)

Target Groups

Adult (18 - 50 Years) Kosher

Product Information

📋 Directions for Use

DIRECTIONS: 2 capsules 2 times daily with meals or as directed by a health care practitioner.

⚠️ Warnings & Precautions

KEEP OUT OF REACH OF CHILDREN.

Zahler(R) MasterMind(TM) does NOT interfere with prescription medications and may be used simultaneously while the drugs are gradually phased out under medical supervision.

🧪 Formulation Notes

KOSHER PAREVE UNDER STRICT SUPERVISION OF RABBI SH. STERN AND THE ORTHODOX UNION

Additional Information

advanced nutrition by ZAHLER(R)

Comprehensive Antidepressant Formula

Restores Mood, Energy & Mental Balance

Restore Mood, Energy & Mental Balance Depression is caused by an imbalance in the brain's neurotransmitters (chemicals which act as the brain's messengers). However, a variety of factors, including genetic makeup, environment, physical condition, mental stressors, psychological and social factors, interact to bring on active depression.

Prevents and Alleviates: ~Major Depression ~Postpartum Depression ~Seasonal Depression ~Dysthymia ~Mood Disorders

You may need additional supplements to support a healthy diet, consult your nutritionist for a formula that is right for you, or call us toll free at 877-ASK-ZAHLER (877-275-9245)

TRIPLE CERTIFIED FORMULA

MIND & SPIRIT {capsule}

D U

STORE TIGHTLY IN COOL, DRY PLACE.

Product Details

DSLD Entry Date 2014-05-23

Product Type Other Combinations

Form Tablet or Pill

Brand Zahler

DSLD ID 33306

Data Updated 2026-04-11

Research Evidence

12 Research Sources

58 Avg Quality Score

8 Meta Analysis

3 Systematic Review

1 Rct

B S-adenosyl-L-methionine for alcoholic liver diseases

Meta Analysis The Cochrane database of systematic reviews 2006

PubMed

B S-adenosyl methionine (SAMe) for depression in adults

Meta Analysis The Cochrane database of systematic reviews 2016

PubMed

B Systemic juvenile idiopathic arthritis and adult-onset Still's disease are the same disease: evidence from systematic reviews and meta-analyses informing the 2023 EULAR/PReS recommendations for the diagnosis and management of Still's disease

Meta Analysis Annals of the rheumatic diseases 2024

PubMed DOI

B SAMe-TT2R2 Score to Predict Time in Therapeutic Range of Vitamin K Antagonists in Asian and Non-Asian patients: A Systematic Review and Meta-analysis

Meta Analysis American journal of cardiovascular drugs : drugs, devices, and other interventions 2024

PubMed DOI

B S-Adenosylmethionine (SAMe) as an adjuvant therapy for patients with depression: An updated systematic review and meta-analysis

Meta Analysis General hospital psychiatry 2024

PubMed DOI

B S-adenosyl-L-methionine for alcoholic liver diseases

Systematic Review The Cochrane database of systematic reviews 2001

PubMed

B WITHDRAWN: S-adenosyl-L-methionine for alcoholic liver diseases

Meta Analysis The Cochrane database of systematic reviews 2015

PubMed DOI

C S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis