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B-Plex

product on market Capsule Karuna Safety: 90/100
90/100

This product looks safe

  • Vitamin B3: 40mg is 1.1× the Tolerable Upper Intake Level (35mg)
  • Vitamin B6: 160mg is 1.6× the Tolerable Upper Intake Level (100mg)
  • Folate: 1360mg is 1360.0× the Tolerable Upper Intake Level (1.0mg)
  • 82% of ingredients have research evidence
F Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

This profile contains a B-vitamin complex, including B1, B2, B3, B6, and folate, which are essential for energy metabolism and neurological function. Research provides strong evidence for the role of these nutrients in cellular health. The formulation maintains a high safety score of 90/100.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Vitamin B3: 40mg is 1.1× the Tolerable Upper Intake Level (35mg)

Vitamin B6: 160mg is 1.6× the Tolerable Upper Intake Level (100mg)

Folate: 1360mg is 1360.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for B-Plex
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Capsule(s)
Serving Size
60
Servings
Other Combinations
Product Type
82%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

100 mg (8333% DV)
83.3× RDA — above typical dose 76 studies (A:0, B:33)
50 mg (3846% DV)
38.5× RDA — above typical dose 13 studies (A:0, B:1)
40 mg (250% DV)
Exceeds UL by 1.1× (UL: 35 mg) 196 studies (A:5, B:63)
160 mg (9411% DV)
Exceeds UL by 1.6× (UL: 100 mg) 114 studies (A:3, B:35)
1360 mcg DFE (200% DV)
Exceeds UL by 1360.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
250 mcg (10417% DV)
104.2× RDA — above typical dose 139 studies (A:1, B:44)
250 mcg (833% DV)
8.3× RDA — above typical dose 27 studies (A:0, B:11)
200 mg (4000% DV)
40.0× RDA — above typical dose 2 studies — no high-quality reviews
50 mg (9% DV)
Within RDA (0.1× RDA) 38 studies (A:1, B:7)
Market median: 500.0mg (9 products) 7 studies — no high-quality reviews
50 mg
Market median: 550.0mg (217 products) 29 studies (A:0, B:5)

Other Ingredients

Hypromellose Water Cellulose Magnesium Stearate
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Info

Product Information

Directions for Use

Suggested use for adults: Two capsules taken daily with meals, or as directed by your health care practitioner.

Formulation Notes

High potency B-complex with phosphorylated B6

Essential B-vitamins in a yeast-free, hypoallergenic form, containing phosphorylated co-enzyme form of vitamin B6

This product is intended for professional use and is manufactured under strict quality control to ensure the optimum in purity, potency and reliability.

This product contains no yeast, wheat, soy, corn, milk, sugar, artificial coloring, preservatives or flavoring.

Additional Information

Keep in a cool, dry place tightly capped.

Metadata

Product Details

UPC / SKU0 18647 01202 7
DSLD Entry Date2025-02-23
Product TypeOther Combinations
FormCapsule
BrandKaruna
DSLD ID327080
Data Updated2026-04-11
Research

Research Evidence

100
Research Sources
56
Avg Quality
48
Systematic Review
30
Meta Analysis
13
Rct
6
Clinical Trial
1
Cochrane Review
1
Regulatory Source
B Thiamine for prevention and treatment of Wernicke-Korsakoff Syndrome in people who abuse alcohol
Systematic Review The Cochrane database of systematic reviews 2013 PubMed DOI
B Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials
Systematic Review Nutritional neuroscience 2023 PubMed DOI
B Effect of thiamine supplementation on glycaemic outcomes in adults with type 2 diabetes: a systematic review and meta-analysis
Meta Analysis BMJ open 2022 PubMed DOI
B Effect of intravenous thiamine administration on critically ill patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
B Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis
Systematic Review Intensive care medicine 2022 PubMed DOI
B Effect of Combined Diclofenac and B Vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) for Low Back Pain Management: Systematic Review and Meta-analysis
Meta Analysis Pain medicine (Malden, Mass.) 2020 PubMed DOI
B Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis
Meta Analysis Critical care medicine 2021 PubMed DOI
B The effects of thiamine supplementation on patients with heart failure: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Complementary therapies in medicine 2022 PubMed DOI
B Hydrocortisone Combined with Vitamin C and Thiamine in the Treatment of Sepsis/Septic Shock: A Systematic Review with Meta-Analysis and Trial Sequential Analysis
Meta Analysis Clinical and investigative medicine. Medecine clinique et experimentale 2023 PubMed DOI
B Thiamine for Wernicke-Korsakoff Syndrome in people at risk from alcohol abuse
Systematic Review The Cochrane database of systematic reviews 2004 PubMed
View all evidence for Thiamine →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.