Home/ Supplements/ Thiamine/ Stress-Defy

Stress-Defy

product on market Softgel Capsule Irwin Naturals Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 47% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

Thiamine is a critical B-vitamin that supports energy metabolism and neurological function, with strong evidence for its role in cellular health. The remaining profile consists of basic macronutrients. Overall evidence coverage for this specific ingredient combination is limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Stress-Defy
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Liquid Softgel(s)
Serving Size
42
Servings
Other Combinations
Product Type
47%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Calories
20 Calorie(s)
Total Fat
1 Gram(s) (2% DV)
Total Carbohydrates
1 Gram(s) (1% DV)
Protein
1 Gram(s)
26 mg (2167% DV)
21.7× RDA — above typical dose 76 studies (A:0, B:33)
26 mg (2000% DV)
20.0× RDA — above typical dose 13 studies (A:0, B:1)
50 mg (2941% DV)
38.5× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
Calcium
19 mg (1% DV)
13 mg (3% DV)
Market median: 500.0mg (1 products) 316 studies (A:8, B:159)
1400 mg
Market median: 1000.0mg (212 products) 12 studies (A:0, B:3)
Chinese Skullcap root extract
200 mg
Market median: 500.0mg (138 products) 2 studies — no high-quality reviews
Market median: 120.0mg (440 products) 191 studies (A:1, B:71)
100 mg
Market median: 200.0mg (358 products) 9 studies (A:0, B:2)
Market median: 300.0mg (122 products) 22 studies (A:0, B:7)
GABA
60 mg
BioPerine Complex
3 mg

Other Ingredients

Gelatin Water, Purified Glycerin Soy Lecithin Beeswax Maltodextrin Titanium Dioxide Turmeric Sodium Copper Chlorophyllin Silicon Dioxide
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Full disclosure ingredient panel Directions: (Adult) Take two (2) liquid soft-gels twice a day with meals and a full glass (8oz) of water.

Warnings & Precautions

Usage warnings: Do not use if safety seal is broken. This product contains an ingredients that may affect blood sugar. Do not exceed recommended daily intake. Warning: (State of California Prop 65) This product contains a chemical known to the State of California to cause birth defects or other reproductive harm.

Check with your doctor if you are using medication, including anti-coagulants (blood thinners), or have any medical conditions, including heart disease or high/low blood pressure. Do not use if you may become pregnant, are pregnant or nursing.

Not intended for use by persons under 18. Keep out of reach of children.

Contains: Soy

Formulation Notes

Stress-Defy - Finding calm in a world of constant stress can seem an impossible task at times. Yet, "stress-management" is essential to your mental, emotional and physical well-being. That's why we developed Stress-Defy - to help counter the effects of occasional stress. This formula is specially designed to create a healthy stress response by promoting relaxation of the body and mind. This comprehensive formula supplies targeted nutrients to help you thrive under times of stress. What makes us different: Liquid Soft-Gels - The nutrients in these easy-to-swallow liquid soft-gels are released fast. Other forms of delivery can contain binders and fillers that may cause stomach upset and offer no traditional value. Advanced Liquid Soft-Gels provide an optimum delivery system. Quality assurance - Irwin Naturals is committed to providing the highest quality products for your health. We employ compliance testing to ensure purity and potency. Global responsibility - Over the years we have donated to organizations that support the environment and the health of children.

Relax your body: Rhodiola has been used traditionally as an adaptogenic botanical that may enhance your body's resistance to stress. Skullcap is traditionally used by herbalist for temporary relief of nervousness. Calm your mind: L-Theanine is a soothing nutrient that supports a relaxed yet alert state of mind without sedation. Ginkgo is prized for it's ability to promote mental functioning. Replenish stress-Fighting Reserves: A combination of essential vitamins, minerals and special botanicals helps to support your central nervous system when you need it the most. Patented BioPerine - Our special BioPerine Complex enhances the bioavailability, absorption and potency of many nutrients.

Balanced Relaxed Calm Stressful day neutralizer Promotes calmness, plus emotional & mental clarity during times of stress

No preservatives added.

Additional Information

Pass Quality Tested Guaranteed

Store in a cool, dry place.

Questions: Contact consumer affairs Weekdays 8:00 AM to 5:00 PM (PST) 100+ highly specialized products: www.IrwinNaturals.com

Metadata

Product Details

UPC / SKU7 10363 56821 4
DSLD Entry Date2025-01-23
Product TypeOther Combinations
FormSoftgel Capsule
BrandIrwin Naturals
DSLD ID323295
Data Updated2026-04-11
Research

Research Evidence

100
Research Sources
56
Avg Quality
48
Systematic Review
30
Meta Analysis
13
Rct
6
Clinical Trial
1
Cochrane Review
1
Regulatory Source
B Thiamine for prevention and treatment of Wernicke-Korsakoff Syndrome in people who abuse alcohol
Systematic Review The Cochrane database of systematic reviews 2013 PubMed DOI
B Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials
Systematic Review Nutritional neuroscience 2023 PubMed DOI
B Effect of thiamine supplementation on glycaemic outcomes in adults with type 2 diabetes: a systematic review and meta-analysis
Meta Analysis BMJ open 2022 PubMed DOI
B Effect of intravenous thiamine administration on critically ill patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
B Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis
Systematic Review Intensive care medicine 2022 PubMed DOI
B Effect of Combined Diclofenac and B Vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) for Low Back Pain Management: Systematic Review and Meta-analysis
Meta Analysis Pain medicine (Malden, Mass.) 2020 PubMed DOI
B Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis
Meta Analysis Critical care medicine 2021 PubMed DOI
B The effects of thiamine supplementation on patients with heart failure: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Complementary therapies in medicine 2022 PubMed DOI
B Hydrocortisone Combined with Vitamin C and Thiamine in the Treatment of Sepsis/Septic Shock: A Systematic Review with Meta-Analysis and Trial Sequential Analysis
Meta Analysis Clinical and investigative medicine. Medecine clinique et experimentale 2023 PubMed DOI
B Thiamine for Wernicke-Korsakoff Syndrome in people at risk from alcohol abuse
Systematic Review The Cochrane database of systematic reviews 2004 PubMed
View all evidence for Thiamine →
Compare

Similar Products

Energy+
Sho · Softgel Capsule
100
Super B Energy Complex
Nature Made · Softgel Capsule
100
Less-Stress Weight Support
Irwin Naturals · Softgel Capsule
100
Super Macho
DLC Laboratories, Inc. · Softgel Capsule
100
B-Complex
Mason Natural · Softgel Capsule
100
View all Thiamine products →
Thiamine research Best Thiamine All Thiamine products More from Irwin Naturals View on NIH DSLD →

This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.